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Rapid detection of MERS coronavirus-like viruses in bats: potential for tracking MERS coronavirus transmission and animal origin

Kong, ChinaPatrick C. Y. Woo, Susanna K. P. Lau, Emily Y. M. Wong, Kwok-Hung Chan, Honglin Chen & Kwok-Yung YuenState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & National ... Chen in:Nature Research journals • PubMed • Google Scholar Search for Emily Y. M. Wong in:Nature Research journals • PubMed • Google Scholar Search for Kwok-Hung Chan in:Nature Research journals

Human H7N9 virus induces a more pronounced pro-inflammatory cytokine but an attenuated interferon response in human bronchial epithelial cells when compared with an epidemiologically-linked chicken H7N9 virus

Background Avian influenza virus H7N9 has jumped species barrier, causing sporadic human infections since 2013. We have previously isolated an H7N9 virus from a patient, and an H7N9 virus from a chicken in a live poultry market where the patient visited during the incubation period. These two viruses were genetically highly similar. This study sought to use a human bronchial...

Distribution, Persistence and Interchange of Epstein-Barr Virus Strains among PBMC, Plasma and Saliva of Primary Infection Subjects

Our study aimed at investigating the distribution, persistence and interchange of viral strains among peripheral blood mononuclear cells (PBMC), plasma and saliva of primary Epstein-Barr virus (EBV) infection subjects. Twelve infectious mononucleosis (IM) patients and eight asymptomatic individuals (AS) with primary EBV infection were followed longitudinally at several time...

Individual Correlates of Infectivity of Influenza A Virus Infections in Households

Background Identifying individual correlates of infectivity of influenza virus is important for disease control and prevention. Viral shedding is used as a proxy measure of infectivity in many studies. However, the evidence for this is limited. Methods In a detailed study of influenza virus transmission within households in 2008–12, we recruited index cases with confirmed...

The Dynamic Relationship Between Clinical Symptomatology and Viral Shedding in Naturally Acquired Seasonal and Pandemic Influenza Virus Infections

Background. Although the pattern of viral shedding over time has been documented in volunteer challenge studies, understanding of the relationship between clinical symptomatology and viral shedding in naturally acquired influenza infections in humans remains limited. Methods. In a community-based study in Hong Kong from 2008 to 2014, we followed up initially healthy individuals...

Polyphyletic origin of MERS coronaviruses and isolation of a novel clade A strain from dromedary camels in the United Arab Emirates

Microbiology, The University of Hong Kong, Hong Kong, ChinaSusanna K P Lau, Emily Y M Wong, Alan K L Tsang, Kwok-Hung Chan, Kwok-Yung Yuen & Patrick C Y WooState Key Laboratory of Emerging Infectious Diseases ... ScholarSearch for Kwok-Hung Chan in:Nature Research journals • PubMed • Google ScholarSearch for Rubeena Muhammed in:Nature Research journals • PubMed • Google ScholarSearch for Jöerg Kinne in:Nature Research

Age-specific epidemic waves of influenza and respiratory syncytial virus in a subtropical city

the Hong Kong Special Administrative Region Government. We thank Dr Ben Cowling and Dr Eric Lau for helpful discussions. Author information Author notesLin Yang & Kwok Hung Chan These authors ... Hong Kong Polytechnic University.Daihai He AuthorsSearch for Lin Yang in:Nature Research journals • PubMed • Google ScholarSearch for Kwok Hung Chan in:Nature Research journals • PubMed • Google

Impact of the 2009 H1N1 Pandemic on Age-Specific Epidemic Curves of Other Respiratory Viruses: A Comparison of Pre-Pandemic, Pandemic and Post-Pandemic Periods in a Subtropical City

Background The 2009 H1N1 influenza pandemic caused offseason peaks in temperate regions but coincided with the summer epidemic of seasonal influenza and other common respiratory viruses in subtropical Hong Kong. This study was aimed to investigate the impact of the pandemic on age-specific epidemic curves of other respiratory viruses. Methods Weekly laboratory-confirmed cases of...

Hospitalization risk of the 2009 H1N1 pandemic cases in Hong Kong

Background Reliable assessment for the severity of the 2009 H1N1 pandemic influenza is critical for evaluation of vaccination strategies for future pandemics. This study aims to estimate the age-specific hospitalization risks of the 2009 pandemic cases during the first wave in Hong Kong, by combining the findings from the serology and disease burden studies. Methods Excess...

Developing an Epidemic Forecasting Model for Influenza A in Brisbane, Australia, Based on Climate and Hong Kong Influenza A Surveillance Data

-Hung Chan 6 Ricardo J. Soares Magalhaes 4 5 Archie C. A. Clements 3 Shi-Lu Tong 1 Wen-Biao Hu 1 0 School of Nursing, Hong Kong Polytechnic University , Hong Kong Special Administrative Region, People's

Epidemiology of human parechovirus, Aichi virus and salivirus in fecal samples from hospitalized children with gastroenteritis in Hong Kong

Background Emerging human picornaviruses, including human parechovirus (HPeV), Aichi virus (AiV) and salivirus (SalV) were found to be associated with gastroenteritis, but their roles in enteric infections are not fully understood. In addition, no report on the circulation of these viruses in Hong Kong is available. The objective of this study was to investigate the prevalence...

Genetic characterization of EV71 isolates from 2004 to 2010 reveals predominance and persistent circulation of the newly proposed genotype D and recent emergence of a distinct lineage of subgenotype C2 in Hong Kong

Background Enterovirus 71 (EV71) is a common etiological agent of hand, foot and mouth disease (HFMD) in children. EV71 epidemics have been reported in Hong Kong in recent years, and yet the genetic information of EV71 strains circulating in our locality is limited. The objective of this study was to investigate the genetic evolution of these EV71 isolates in Hong Kong over a 7...

Differential cell line susceptibility to the emerging Zika virus: implications for disease pathogenesis, non-vector-borne human transmission and animal reservoirs

, Kin-Hang Kok, Kwok-Hung Chan & Kwok-Yung YuenResearch Centre of Infection and Immunology, The University of Hong Kong, Hong Kong, ChinaJasper Fuk-Woo Chan, Kin-Hang Kok & Kwok-Yung YuenCarol Yu Centre ... journals • PubMed • Google ScholarSearch for Dong-Yan Jin in:Nature Research journals • PubMed • Google ScholarSearch for Kwok-Hung Chan in:Nature Research journals • PubMed • Google ScholarSearch for Kwok

The Therapeutic Effect of Pamidronate on Lethal Avian Influenza A H7N9 Virus Infected Humanized Mice

A novel avian influenza virus H7N9 infection occurred among human populations since 2013. Although the lack of sustained human-to-human transmission limited the epidemics caused by H7N9, the late presentation of most patients and the emergence of neuraminidase-resistant strains made the development of novel antiviral strategy against H7N9 in urgent demands. In this study, we...

Estimation of the Association Between Antibody Titers and Protection Against Confirmed Influenza Virus Infection in Children

Antibody titers measured by hemagglutination inhibition (HAI) correlate with protection against influenza virus infection and are used to specify criteria for vaccine licensure. In a randomized, controlled trial of seasonal influenza vaccination in 773 children aged 6–17 years, we estimated that HAI titers of 1:40 against A(H1N1)pdm09 and B(Victoria lineage) were associated with...

A Robust Parameter Estimation Method for Estimating Disease Burden of Respiratory Viruses

Background Poisson model has been widely applied to estimate the disease burden of influenza, but there has been little success in providing reliable estimates for other respiratory viruses. Methods We compared the estimates of excess hospitalization rates derived from the Poisson models with different combinations of inference methods and virus proxies respectively, with the aim...

Population-Based Hospitalization Burden of Influenza A Virus Subtypes and Antigenic Drift Variants in Children in Hong Kong (2004–2011)

Objectives We aim to document and analyze influenza hospitalization burden in light of antigenic changes in circulating influenza viruses in Hong Kong. Methods The pediatric age-specific rates of influenza A hospitalization in Hong Kong for 2004–2011 which encompassed the emergence of H1N1pdm09 were extrapolated from admissions to 2 hospitals that together catered for 72.5% of...

Immunogenicity of Intradermal Trivalent Influenza Vaccine With Topical Imiquimod: A Double Blind Randomized Controlled Trial

Background. Imiquimod, a synthetic Toll-like receptor 7 agonist enhanced immunogenicity of influenza vaccine in a mouse model. We hypothesized that topical imiquimod before intradermal influenza vaccination (TIV) would produce similar effect in human. Methods. We performed a prospective 1-year follow-up, double-blind, randomized, controlled trial with adults with comorbidities...