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Global DNA methylation changes spanning puberty are near predicted estrogen-responsive genes and enriched for genes involved in endocrine and immune processes

BackgroundThe changes that occur during puberty have been implicated in susceptibility to a wide range of diseases later in life, many of which are characterized by sex-specific differences in prevalence. Both genetic and environmental factors have been associated with the onset or delay of puberty, and recent evidence has suggested a role for epigenetic changes in the initiation...

Evaluation of drug mechanism and efficacy of a novel anti-angiogenic agent, TTAC-0001, using multi-modality bioimaging in a mouse breast cancer orthotopic model

Education(2016R1D1A1A02937258). Author Contributions Conceptualization: Sang Hyun Choi, Kyung Won Kim, Yoonseok Choi. Data curation: Jinil Kim, Su Jung Ham, Young Chul Cho, Seul-I Lee, Jeeheon Kang. Formal ... analysis: Jinil Kim, Sang Hyun Choi, Su Jung Ham, Seul-I Lee, Jeeheon Kang, Dong Cheol Woo, Kyung Won Kim, Yoonseok Choi. Funding acquisition: Yoonseok Choi. Investigation: Jinil Kim, Sang Hyun Choi, Su

Coordinated inhibition of C/EBP by Tribbles in multiple tissues is essential for Caenorhabditis elegans development

Background Tribbles proteins are conserved pseudokinases that function to control kinase signalling and transcription in diverse biological processes. Abnormal function in human Tribbles has been implicated in a number of diseases including leukaemia, metabolic syndromes and cardiovascular diseases. Caenorhabditis elegans Tribbles NIPI-3 was previously shown to activate host...

The administration of hydrogen sulphide prior to ischemic reperfusion has neuroprotective effects in an acute stroke model

analysis: Chul-Woong Woo. Funding acquisition: Hyun Kwon Ha, Dong-Cheol Woo. Investigation: Chul-Woong Woo, Jae-Im Kwon, Kyung-Won Kim, Jeong-Kon Kim, Sang Tae Kim, Su Jeong Ham. Methodology: Chul-Woong ... Woo, Jae-Im Kwon, Sang-Beom Jeon, Jinil Kim. Project administration: Jae-Im Kwon, Yoonseok Choi. Supervision: Kyung-Won Kim, Jeong-Kon Kim, Sang-Beom Jeon, Seung-Chae Jung, Choong-Gon Choi, Hyun Kwon

Neurochemical Changes Associated with Stress-Induced Sleep Disturbance in Rats: In Vivo and In Vitro Measurements

The goal of this study was to quantitatively assess the changes in the cerebral neurochemical profile and to identify those factors that contribute to the alteration of endogenous biomolecules when rats are subjected to stress-induced sleep disturbance. We exposed Sprague-Dawley rats (controls: n = 9; stress-induced sleep perturbation rats: n = 11) to a psychological stressor...

Numerical investigation on composite porous layers in electroosmotic flow

INTERNATIONAL JOURNAL OF PRECISION ENGINEERING AND MANUFACTURING-GREEN TECHNOLOGY Numerical Investigation on Composite Porous Layers in Electroosmotic Flow Taqi Ahmad Cheema 0 Kyung Won Kim 0 Moon

Additive Effect between IL-13 Polymorphism and Cesarean Section Delivery/Prenatal Antibiotics Use on Atopic Dermatitis: A Birth Cohort Study (COCOA)

Background Although cesarean delivery and prenatal exposure to antibiotics are likely to affect the gut microbiome in infancy, their effect on the development of atopic dermatitis (AD) in infancy is unclear. The influence of individual genotypes on these relationships is also unclear. To evaluate with a prospective birth cohort study whether cesarean section, prenatal exposure to...

Inhalation Toxicity of Humidifier Disinfectants as a Risk Factor of Children’s Interstitial Lung Disease in Korea: A Case-Control Study

Background The occurrence of numerous cases of interstitial lung disease in children (chILD) every spring in Korea starting in 2006 raised suspicion about a causal relationship with the use of humidifier disinfectants (HDs). The aim of this study was to evaluate the association between HD use and the risk of chILD. Methods This retrospective, 1∶3 matched case-control study...