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12 papers found.
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Decreased cryogenic disturbance: one of the potential mechanisms behind the vegetation change in the Arctic

During the last few decades, the Arctic has experienced large-scale vegetation changes. Understanding the mechanisms behind this vegetation change is crucial for our ability to predict future changes. This study tested the hypothesis that decreased cryogenic disturbances cause vegetation change in patterned ground study fields (non-sorted circles) in Abisko, Sweden during the last ...

Which set of embryo variables is most predictive for live birth? A prospective study in 6252 single embryo transfers to construct an embryo score for the ranking and selection of embryos

STUDY QUESTION Which embryo score variables are most powerful for predicting live birth after single embryo transfer (SET) at the early cleavage stage?

A high activity index of stearoyl-CoA desaturase is associated with increased risk of fracture in men

Summary The activity index of stearoyl-CoA desaturase (SCD), a key enzyme in lipogenesis, was associated with increased risk of fracture in a longitudinal population-based cohort of men. This indicates that elevated levels of endogenous lipogenesis increase the risk of fracture and suggest a role for saturated fat in the pathogenesis of osteoporosis. Introduction Osteoblasts and ...

Construction of an evidence-based integrated morphology cleavage embryo score for implantation potential of embryos scored and transferred on day 2 after oocyte retrieval

BACKGROUND: Evidence-based morphological embryo scoring models for ranking of implantation potential are still scarce, and the need for a precise model increases when aiming for singleton pregnancies. METHODS: Prospectively, 2266 IVF/ICSI double-embryo, day 2 transfers were studied. The five variables scored in 3- to 5-step scales for the embryos transferred are blastomere number ...

SELECTED ORAL COMMUNICATION SESSION, SESSION 43: EMBRYOLOGY – TIME AND SPATIAL DEVELOPMENT, Tuesday 5 July 2011 15:15 – 16:30

Introduction: Time-lapse observation opens the opportunity for optimizing morphological grading as well as providing novel kinetic parameters, which may aid in the selection of viable embryos. The objective of this analysis was to identify morphokinetic parameters such as timings of and intervals between cell divisions differing between implanting and non-implanting embryos. ...

Influence of variation at the apolipoprotein E locus on lipid and lipoprotein levels in CAPD patients.

BACKGROUND: Variation at the apolipoprotein E (apo E) locus influence lipid and lipoprotein levels in the normal population, and is associated with premature coronary artery disease. Patients with end-stage kidney disease or undergoing dialysis treatment are particularly prone to develop accelerated atherosclerosis. METHODS: To evaluate the influence of genetic variation at the apo ...

Prediction models for insulin resistance in the polycystic ovary syndrome

Women with the polycystic ovary syndrome (PCOS) have a high prevalence of insulin resistance, with consequent increased risk of metabolic diseases later in life. An early metabolic screening would therefore be of clinical relevance. By using stepwise regression analysis on several variables obtained in 72 women with PCOS, we constructed simple and reliable mathematical models ...

Polymorphism in the glycogen-associated regulatory subunit of type 1 protein phosphatase (PPP1R3) gene and insulin sensitivity.

A polymorphism (PP1ARE) in the 3'-untranslated region of the gene encoding the glycogen-associated regulatory subunit of type 1 protein phosphatase PPP1R3 is associated with insulin resistance in Pima Indians. The aim of this study was to investigate whether two common variants in the PPP1R3 gene, Asp905Tyr and PP1ARE, are associated with reduced insulin sensitivity or can predict ...

Studies of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) gene in relation to insulin sensitivity among glucose tolerant Caucasians

Aims/hypothesis: We examined whether the Pro12-Ala polymorphism of the human peroxisome proliferator-activated receptor-γ2 (PPAR- γ 2) gene was related to altered insulin sensitivity among glucose-tolerant subjects or a lower accumulated incidence or prevalence of IGT and Type II (non-insulin-dependent) diabetes mellitus among Scandinavian Caucasians. Methods: The Pro12Ala ...

Substituting dietary saturated for monounsaturated fat impairs insulin sensitivity in healthy men and women: The KANWU study

Aims/hypothesis. The amount and quality of fat in the diet could be of importance for development of insulin resistance and related metabolic disorders. Our aim was to determine whether a change in dietary fat quality alone could alter insulin action in humans. Methods. The KANWU study included 162 healthy subjects chosen at random to receive a controlled, isoenergetic diet for 3 ...

Studies of the genetic variability of the coding region of the hepatocyte nuclear factor-4α in Caucasians with maturity onset NIDDM

Mutations in the hepatocyte nuclear factor-4α (HNF-4α) gene cause the type 1 form of maturity onset diabetes of the young (MODY1). To address the question of whether genetic variability of HNF-4α is associated with late onset non-insulin-dependent diabetes mellitus (NIDDM) we have sequenced the coding region and intron/exon boundaries of the gene in 36 randomly recruited Danish ...

Search for variants of the gene-promoter and the potential phosphotyrosine encoding sequence of the insulin receptor substrate-2 gene: evaluation of their relation with alterations in insulin secretion and insulin sensitivity

K. Almind S. K. Frederiksen D. Bernal T. Hansen L. Ambye S. Urhammer C. T. Ekstrm L. Berglund R. Reneland H. Lithell M. F. White E. Van Obberghen O. Pedersen Aims/hypothesis. The aim of this study