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Back to the Grindstone? The Archaeological Potential of Grinding-Stone Studies in Africa with Reference to Contemporary Grinding Practices in Marakwet, Northwest Kenya

This article presents observations on grinding-stone implements and their uses in Elgeyo-Marakwet County, northwest Kenya. Tool use in Marakwet is contextualized with a select overview of literature on grinding-stones in Africa. Grinding-stones in Marakwet are incorporated not only into quotidian but also into more performative and ritual aspects of life. These tools have distinct ...

Citrullination only infrequently impacts peptide binding to HLA class II MHC

It has been hypothesized that HLA class II alleles associated with rheumatoid arthritis (RA) preferentially present self-antigens altered by post-translational modification, such as citrullination. To understand the role of citrullination we tested four RA-associated citrullinated epitopes and their corresponding wild-type version for binding to 28 common HLA class II. Binding ...

Behaviour change interventions to influence antimicrobial prescribing: a cross-sectional analysis of reports from UK state-of-the-art scientific conferences

Background To improve the quality of antimicrobial stewardship (AMS) interventions the application of behavioural sciences supported by multidisciplinary collaboration has been recommended. We analysed major UK scientific research conferences to investigate AMS behaviour change intervention reporting. Methods Leading UK 2015 scientific conference abstracts for 30 clinical ...

Respiratory Syncytial Virus-Infected Mesenchymal Stem Cells Regulate Immunity via Interferon Beta and Indoleamine-2,3-Dioxygenase

. Martin L. Moore was supported by NIH R01AI087798 and NIH U19AI095227. Mr. Ryan Green was supported by the American Heart Association (US 15PRE25760005). The funders had no role in study design, data

Mammalian Cell-Derived Respiratory Syncytial Virus-Like Particles Protect the Lower as well as the Upper Respiratory Tract

Globally, Respiratory Syncytial Virus (RSV) is a leading cause of bronchiolitis and pneumonia in children less than one year of age and in USA alone, between 85,000 and 144,000 infants are hospitalized every year. To date, there is no licensed vaccine. We have evaluated vaccine potential of mammalian cell-derived native RSV virus-like particles (RSV VLPs) composed of the two ...

The Cost Of Privacy: Riley v. California’s Impact on Cell Phone Searches

- This work is licensed under a Creative Commons Attribution 4.0 International License. Jennifer L. Moore, Jonathan Langton, and Joseph Pochron DeSales University 2755 Station Avenue, Center Valley

Atlantic salmon (Salmo salar L.) post-smolts challenged two or nine weeks after seawater-transfer show differences in their susceptibility to salmonid alphavirus subtype 3 (SAV3)

Background Pancreas disease (PD), caused by salmonid alphavirus (SAV), is an important disease affecting salmonid aquaculture. It has been speculated that Atlantic salmon post-smolts are more prone to infections in the first few weeks following seawater- transfer. After this period of seawater acclimatization, the post-smolts are more robust and better able to resist infection by ...

Integrative modeling reveals the principles of multi-scale chromatin boundary formation in human nuclear organization

Background Interphase chromosomes adopt a hierarchical structure, and recent data have characterized their chromatin organization at very different scales, from sub-genic regions associated with DNA-binding proteins at the order of tens or hundreds of bases, through larger regions with active or repressed chromatin states, up to multi-megabase-scale domains associated with nuclear ...

The Optimal Number of Surveys when Detectability Varies

The survey of plant and animal populations is central to undertaking field ecology. However, detection is imperfect, so the absence of a species cannot be determined with certainty. Methods developed to account for imperfect detectability during surveys do not yet account for stochastic variation in detectability over time or space. When each survey entails a fixed cost that is not ...

Systematic quantification of developmental phenotypes at single-cell resolution during embryogenesis

Julia L. Moore 0 Zhuo Du 0 Zhirong Bao () 0 0 Developmental Biology Program, Sloan-Kettering Institute , New York, NY 10065 , USA SUMMARY Current imaging technology provides an experimental platform

The role of nodes in arsenic storage and distribution in rice

Knowledge of arsenic (As) accumulation in rice (Oryza sativa L.) is important for minimizing As transfer to the food chain. The aim of this study was to investigate the role of rice nodes in As storage and distribution. Synchrotron μX-ray fluorescence (μ-XRF) was used to map As distribution in the top node and internode of a lsi2 mutant defective in silicon/arsenite efflux carrier ...

RSV-Induced H3K4 Demethylase KDM5B Leads to Regulation of Dendritic Cell-Derived Innate Cytokines and Exacerbates Pathogenesis In Vivo

Respiratory syncytial virus (RSV) infection can result in severe disease partially due to its ability to interfere with the initiation of Th1 responses targeting the production of type I interferons (IFN) and promoting a Th2 immune environment. Epigenetic modulation of gene transcription has been shown to be important in regulating inflammatory pathways. RSV-infected bone ...

Genetic and Ecotypic Differentiation in a Californian Plant Polyploid Complex (Grindelia, Asteraceae)

L. Moore 0 Bruce G. Baldwin 0 Daniel Ortiz-Barrientos, The University of Queensland, St. Lucia, Australia 0 1 Institut fu r Spezielle Botanik und Botanischer Garten, Johannes Gutenberg-Universita t ... ; the Jepson Herbarium (JEPS) for housing voucher specimens; D. D. Ackerly, R. Byrne, J. W. Kadereit, B. D. Mishler, J. L. Moore, D. Ortiz-Barrientos, and four anonymous reviewers for comments that

Trends in perinatal deaths from 2010 to 2013 in the Guatemalan Western Highlands

Background While progress has been made in reducing neonatal mortality in Guatemala, stillbirth and maternal mortality rates remain high, especially among the indigenous populations, which have among the highest adverse pregnancy-related mortality rates in Guatemala. Methods We conducted a prospective study in the Western Highlands of Guatemala from 2010 through 2013, enrolling ...

Methanol-based fixation is superior to buffered formalin for next-generation sequencing of DNA from clinical cancer samples

Background Next-generation sequencing (NGS) of tumour samples is a critical component of personalised cancer treatment, but it requires high-quality DNA samples. Routine neutral-buffered formalin (NBF) fixation has detrimental effects on nucleic acids, causing low yields, as well as fragmentation and DNA base changes, leading to significant artefacts.

Football Fan Aggression: The Importance of Low Basal Cortisol and a Fair Referee

Fan aggression in football (soccer) is a societal problem that affects many countries worldwide. However, to date, most studies use an epidemiological or survey approach to explain football fan aggression. This study used a controlled laboratory study to advance a model of predictors for fan aggression. To do so, football fans (n = 74) saw a match summary in which their favorite ...

A New Method for Assessing How Sensitivity and Specificity of Linkage Studies Affects Estimation

Background While the importance of record linkage is widely recognised, few studies have attempted to quantify how linkage errors may have impacted on their own findings and outcomes. Even where authors of linkage studies have attempted to estimate sensitivity and specificity based on subjects with known status, the effects of false negatives and positives on event rates and ...

Evaluation of anti-citrullinated type II collagen and anti-citrullinated vimentin antibodies in patients with juvenile idiopathic arthritis

Terry L Moore 0 1 0 Division of Adult and Pediatric Rheumatology, Internal Medicine , Pediatrics, and Molecular Microbiology and Immunology , Saint Louis University School of Medicine , Saint Louis