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Search: authors:"L.P.B. Elbers"

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Thyroid Hormone Mimetics: the Past, Current Status and Future Challenges

The association between thyroid hormone status and plasma levels of low-density lipoprotein cholesterol has raised the awareness for the development of thyroid hormone mimetics as lipid-lowering agents. The discovery of the two main types of thyroid hormone receptors (α and β) as well as the development of novel combinatorial chemistry providing organ specificity has drastically...