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Copula–entropy theory for multivariate stochastic modeling in water engineering

The copula–entropy theory combines the entropy theory and the copula theory. The entropy theory has been extensively applied to derive the most probable univariate distribution subject to specified constraints by applying the principle of maximum entropy. With the flexibility to model nonlinear dependence structure, parametric copulas (e.g., Archimedean, extreme value, meta...

Canonical correlation analysis (CCA) of anthropometric parameters and physical activities with blood lipids

Anthropometric parameters and physical activities are significant factors influencing lipid levels, but few research have demonstrated the effect of amount of activities on lipid levels. Our research analyzed and explored this relationships. A multi-stage stratified sampling method was used to select the investigation subjects in Hubei, China. A questionnaire survey, physical...

Replacing methyl bromide with a combination of 1,3-dichloropropene and metam sodium for cucumber production in China

Cao. 9 / 11 Formal analysis: Liangang Mao, Lan Zhang. Funding acquisition: Hongyun Jiang, Aocheng Cao. Investigation: Liangang Mao, Yanning Zhang, Haitao Yu. Methodology: Liangang Mao, Aocheng Cao

Soil phosphorus functional fractions and tree tissue nutrient concentrations influenced by stand density in subtropical Chinese fir plantation forests

: Fu-Sheng Chen. Investigation: Xiu-Lan Zhang, Ying-Ying Zong, Yang Zhang. 15 / 17 Writing ± original draft: Xiang-Min Fang. Writing ± review & editing: Xiang-Min Fang, Fu-Sheng Chen. 16 / 17 1

miR-1296-5p decreases ERBB2 expression to inhibit the cell proliferation in ERBB2-positive breast cancer

The tumor suppressive role of miR-1296 is observed in triple negative breast cancer (TNBC). However, the effect of miR-1296-5p in ERBB2-positive breast cancers remains obscure. Whether ERBB2 was the target gene of the miR-1296-5p was predicted by online software, and determined by dual-luciferase activity assay. miR-1296-5p expression levels were determined in breast cancer...

Psychological and somatic distress in Chinese outpatients at general hospitals: a cross-sectional study

Our study aimed (1) to describe the proportion of psychological distress among Chinese outpatients at general hospitals, (2) to compare cognitive and behavioral characteristics of patients with different distress patterns, and (3) to investigate the discriminant function of the analyzed variables in indicating the affinity towards the different distress patterns. This multicenter...

Left innominate vein stenosis in an asymptomatic population: a retrospective analysis of 212 cases

Background Although left innominate vein (LIV) stenosis has been demonstrated to be attributed to compression by adjacent anatomical structures, most of the studies are focusing on hemodialysis patients with clinical symptoms compatible with LIV stenosis. The goal of this study was to retrospectively investigate the incidence of LIV stenosis and its influencing factors in an...

Expression and prognostic significance of MYL9 in esophageal squamous cell carcinoma

Objective Myosin light chain 9 (MYL9) is necessary for cytoskeletal dynamics and experimental metastasis, but its expression in esophageal squamous cell carcinoma (ESCC) has not been addressed. We investigated the expression pattern and clinical significance of MYL9 in patients with ESCC. Methods We examined MYL9 expression using quantitative real-time PCR and western blotting in...

Infant feeding and health-related quality of life in healthy Chinese infants: results from a prospective, observational cohort study

Background Infant feeding regimens, including breastfeeding, formula-feeding, or a combination of the two, may influence infant health-related quality of life (HRQOL). However, few studies have examined this association. Methods This prospective cohort study assessed HRQOL in relation to three parent-selected feeding regimens: exclusively breastfed (n = 136), exclusively study...

miR 1296-5p Inhibits the Migration and Invasion of Gastric Cancer Cells by Repressing ERBB2 Expression

The metastasis of gastric cancer, one of the most common tumors, has a molecular mechanism that is still largely unclear. Here we investigated the role of possible tumor-suppressor miR-1296-5p in the cell migration and invasion of ERBB2-positive gastric cancer. It found that miR-1296-5p was significantly down-regulated in gastric cancer tissues. Moreover, it was down-regulated in...

A polymorphism at the microRNA binding site in the 3' untranslated region of RYR3 is associated with outcome in hepatocellular carcinoma

A polymorphism at the microRNA binding site in the 3' untranslated region of RYR3 is associated with outcome in hepatocellular carcinoma Chenxing Peng,1 Zhanjun Guo,2 Xiaoyan Wu,3 Xiao-lan Zhang1 1Department of Gastroenterology and Hepatology, The Second Hospital of Hebei Medical University, 2Department of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical...

Mass spectrometry based proteomics profiling of human monocytes

point. COMPLIANCE WITH ETHICS GUIDELINES Yong Zeng, Fei-Yan Deng, Wei Zhu, Lan Zhang, Hao He, Chao Xu, Qing Tian, Ji-Gang Zhang, Li-Shu Zhang, Hong-Gang Hu and HongWen Deng declare that they have no

Tadalafil Promotes the Recovery of Peripheral Neuropathy in Type II Diabetic Mice

We previously demonstrated that treatment of diabetic peripheral neuropathy with the short (4 hours) half-life phosphodiesterase 5 (PDE5) inhibitor, sildenafil, improved functional outcome in diabetic db/db mice. To further examine the effect of PDE5 inhibition on diabetic peripheral neuropathy, we investigated the effect of another potent PDE5 inhibitor, tadalafil, on diabetic...

Establishing guidelines for CAR-T cells: challenges and considerations

T cells, genetically modified by chimeric antigen receptors (CAR-T), are endowed with specificity to a desired antigen and are cytotoxic to cells expressing the targeted antigen. CAR-T-based cancer immunotherapy is a promising therapy for curing hematological malignancy, such as acute lymphoid leukemia, and is promising for extending their efficacy to defeat solid tumors. To date...

How Business Professionals Perceive Intercultural Differences: A Survey

This article reports the findings of a survey conducted among business professionals who have either worked in China or are US based and have relationships with Chinese companies. The intention is to discover what business culture differences they perceive between the US and China and how they cope with the language and cultural challenges. As a result, Chinese language...

Stability Characterization of a Vaccine Antigen Based on the Respiratory Syncytial Virus Fusion Glycoprotein

Infection with Respiratory Syncytial Virus (RSV) causes both upper and lower respiratory tract disease in humans, leading to significant morbidity and mortality in both young children and older adults. Currently, there is no licensed vaccine available, and therapeutic options are limited. During the infection process, the type I viral fusion (F) glycoprotein on the surface of the...

Targeted sequencing identifies a novel SH2D1A pathogenic variant in a Chinese family: Carrier screening and prenatal genetic testing

X-linked lymphoproliferative disease type 1 (XLP1) is a rare primary immunodeficiency characterized by a clinical triad consisting of severe EBV-induced hemophagocytic lymphohistiocytosis, B-cell lymphoma, and dysgammaglobulinemia. Mutations in SH2D1A gene have been revealed as the cause of XLP1. In this study, a pregnant woman with recurrence history of birthing immunodeficiency...

WNT2 Promotes Cervical Carcinoma Metastasis and Induction of Epithelial-Mesenchymal Transition

Background Previously, we found an 11-gene signature could predict pelvic lymph node metastasis (PLNM), and WNT2 is one of the key genes in the signature. This study explored the expression and underlying mechanism of WNT2 in PLNM of cervical cancer. Methods WNT2 expression level in cervical cancer was detected using western blotting, quantitative PCR, and immunohistochemistry...

Recombinant expression of Chlamydia trachomatis major outer membrane protein in E. Coli outer membrane as a substrate for vaccine research

Robin M. Kaufhold Puneet Khandelwal Eberhard Durr Ping Qiu Bob J. Lucas Debbie D. Nahas James C. Cook Sinoeun Touch Julie M. Skinner Amy S. Espeseth Craig T. Przysiecki Lan Zhang Background: Chlamydia ... title page of the manuscript. Lan Zhang, Zhiyun Wen, Craig T. Przysiecki, Puneet Khandelwal and Ping Qiu are currently applying for a patent relating to the content of the manuscript (International