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Potential Effect of Prolonged Sevoflurane Anesthesia on the Kinetics of [11C]Raclopride in Non-human Primates

^ (Dnr 4820/06-600) of Karolinska Institutet. Conflict of Interest Lars Farde is employed by AstraZeneca and affiliated with Karolinska Insitutet. All other authors declare that they have no conflict of

Assessment of simplified ratio-based approaches for quantification of PET [11C]PBR28 data

Purpose Kinetic modelling with metabolite-corrected arterial plasma is considered the gold standard for quantification of [11C]PBR28 binding to the translocator protein (TSPO), since there is no brain region devoid of TSPO that can serve as reference. The high variability in binding observed using this method has motivated the use of simplified ratio-based approaches such as...

TSPO binding may also represent ‘resting’ microglia

, Sweden 1 & Lars Farde - Inflammation has since long been identified as part of the pathophysiology of the majority of human diseases, and over the last decades it has become clear that it also has a role ... of radioligands for a series of different targets is required to examine the postulated importance of inflammation in major CNS disorders. Compliance with ethical standards Conflict of interest Lars

GABAA receptor occupancy by subtype selective GABAAα2,3 modulators: PET studies in humans

RationaleSedation, dependence, and abuse liability limit the use of non-selective γ-aminobutyric acid (GABAA) receptor positive modulators for the treatment of anxiety. AZD7325 and AZD6280 are novel, subtype-selective GABAAα2,3 receptor positive modulators with limited sedative effects.ObjectivesThe current study aimed to confirm target engagement at GABAA receptors by AZD7325...

Characterization of [11C]Lu AE92686 as a PET radioligand for phosphodiesterase 10A in the nonhuman primate brain

Purpose[11C]Lu AE92686 is a positron emission tomography (PET) radioligand that has recently been validated for examining phosphodiesterase 10A (PDE10A) in the human striatum. [11C]Lu AE92686 has high affinity for PDE10A (IC 50 = 0.39 nM) and may also be suitable for examination of the substantia nigra, a region with low density of PDE10A. Here, we report characterization of...

Identification of positron emission tomography (PET) tracer candidates by prediction of the target-bound fraction in the brain

Background Development of tracers for imaging with positron emission tomography (PET) is often a time-consuming process associated with considerable attrition. In an effort to simplify this process, we herein propose a mechanistically integrated approach for the selection of tracer candidates based on in vitro measurements of ligand affinity (Kd), non-specific binding in brain...

Application of cross-species PET imaging to assess neurotransmitter release in brain

treatment of mental illness in mammals and a composition therefore^ (1999). Jukka Sallinen and Mo Shahid are employed by Orion Corporation. Lars Farde and Erik Wong either are, or have been, employed by

Kinetic analysis and test-retest variability of the radioligand [11C](R)-PK11195 binding to TSPO in the human brain - a PET study in control subjects

Background Positron-emission tomography and the radioligand [11C](R)-PK11195 have been used for the imaging of the translocator protein (TSPO) and applied to map microglia cells in the brain in neuropsychiatric disorders. [11C](R)-PK11195 binding has been quantified using reference region approaches, with the reference defined anatomically or using unsupervised or supervised...

Thinking Outside a Less Intact Box: Thalamic Dopamine D2 Receptor Densities Are Negatively Related to Psychometric Creativity in Healthy Individuals

Cervenka Anke Karabanov 0 Lars Farde Fredrik Ulle´ n 0 Aldo Rustichini, University of Minnesota, United States of America 0 Neuropediatric Research Unit, Department of Women's and Children's Health and

Dopamine D1 Receptor Associations within and between Dopaminergic Pathways in Younger and Elderly Adults: Links to Cognitive Performance

Age-related dopamine (DA) losses have been extensively demonstrated for the D2 receptor subtype. Comparatively little is known about adult age changes regarding D1 receptors. In this study, we demonstrate marked age-related D1 receptor losses in striatal, limbic, and cortical areas using positron emission tomography and the radioligand [11C]SCH23390 in humans. Interregional...

Low background and high contrast PET imaging of amyloid-β with [11C]AZD2995 and [11C]AZD2184 in Alzheimer’s disease patients

Purpose The aim of this study was to evaluate AZD2995 side by side with AZD2184 as novel PET radioligands for imaging of amyloid-β in Alzheimer’s disease (AD). Methods In vitro binding of tritium-labelled AZD2995 and AZD2184 was studied and compared with that of the established amyloid-β PET radioligand PIB. Subsequently, a first-in-human in vivo PET study was performed using...

Detection of amyloid in Alzheimer’s disease with positron emission tomography using [11C]AZD2184

Svante Nyberg Maria Eriksdotter Jnhagen Zsolt Cselnyi Christer Halldin Per Julin Hans Olsson Yvonne Freund-Levi Jan Andersson Katarina Varns Samuel Svensson Lars Farde Purpose Current positron