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Guidelines for Biomarker of Food Intake Reviews (BFIRev): how to conduct an extensive literature search for biomarker of food intake discovery

Identification of new biomarkers of food and nutrient intake has developed fast over the past two decades and could potentially provide important new tools for compliance monitoring and dietary intake assessment in nutrition and health science. In recent years, metabolomics has played an important role in identifying a large number of putative biomarkers of food intake (BFIs...

A scheme for a flexible classification of dietary and health biomarkers

Manach 5 Lorraine Brennan 4 Lydia A. Afman 9 David S. Wishart 8 Cristina Andres-Lacueva 3 11 Mar Garcia-Aloy 3 11 Hans Verhagen 10 12 Edith J. M. Feskens 9 Lars O. Dragsted 0 0 Department of Nutrition

Effect of trans Fatty Acid Intake on LC-MS and NMR Plasma Profiles

Background The consumption of high levels of industrial trans fatty acids (TFA) has been related to cardiovascular disease, diabetes and sudden cardiac death but the causal mechanisms are not well known. In this study, NMR and LC-MS untargeted metabolomics has been used as an approach to explore the impact of TFA intake on plasma metabolites. Methodology/Principal Findings In a...

Self-Reported Whole-Grain Intake and Plasma Alkylresorcinol Concentrations in Combination in Relation to the Incidence of Colorectal Cancer

Olsen Lars O. Dragsted Guri Skeie Eiliv Lund Per Åman Lena M. Nilsson H. B. Bueno-de-Mesquita Anne Tjønneland Rikard Landberg American Journal of Epidemiology © The Author 2014. Published by Oxford ... ); Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark (Lars O. Dragsted); Department of Community Medicine, University of Tromsø, Tromsø, Norway (Guri Skeie, Eiliv Lund

Effects of a healthy Nordic diet on gene expression changes in peripheral blood mononuclear cells in response to an oral glucose tolerance test in subjects with metabolic syndrome: a SYSDIET sub-study

6 Karl-Heinz Herzig 5 9 Lieselotte Cloetens 8 Matilda Ulmius Storm 8 Janne Hukkanen 4 11 12 Markku J. Savolainen 4 11 12 Fredrik Rosqvist 10 Kjeld Hermansen Lars O. Dragsted Ingibjörg Gunnarsdottir

Dietary carbohydrate source influences molecular fingerprints of the rat faecal microbiota

Background A study was designed to elucidate effects of selected carbohydrates on composition and activity of the intestinal microbiota. Five groups of eight rats were fed a western type diet containing cornstarch (reference group), sucrose, potato starch, inulin (a long- chained fructan) or oligofructose (a short-chained fructan). Fructans are, opposite sucrose and starches, not...

Effects of apples and specific apple components on the cecal environment of conventional rats: role of apple pectin

Background Our study was part of the large European project ISAFRUIT aiming to reveal the biological explanations for the epidemiologically well-established health effects of fruits. The objective was to identify effects of apple and apple product consumption on the composition of the cecal microbial community in rats, as well as on a number of cecal parameters, which may be...

Exposure to ambient concentrations of particulate air pollution does not influence vascular function or inflammatory pathways in young healthy individuals

Background Particulate air pollution is associated with increased risk of cardiovascular events although the involved mechanisms are poorly understood. The objective of the present study was to investigate the effects of controlled exposure to ambient air fine and ultrafine particles on microvascular function and biomarkers related to inflammation, haemostasis and lipid and...

Challenges of molecular nutrition research 6: the nutritional phenotype database to store, share and evaluate nutritional systems biology studies

The challenge of modern nutrition and health research is to identify food-based strategies promoting life-long optimal health and well-being. This research is complex because it exploits a multitude of bioactive compounds acting on an extensive network of interacting processes. Whereas nutrition research can profit enormously from the revolution in ‘omics’ technologies, it has...

Associations between GPX1 Pro198Leu polymorphism, erythrocyte GPX activity, alcohol consumption and breast cancer risk in a prospective cohort study

Breast cancer may be related to oxidative stress. Breast cancer patients have been reported to have lower antioxidant enzyme activity than healthy controls and the polymorphism GPX1 Pro198Leu has been associated with risk of lung and breast cancer. The purpose of the present nested case-control study was to determine whether GPX1 Pro198Leu and glutathione peroxidase (GPX...

Mutagenicity of 2-amino-3-methylimidazo[4,5-f]quinoline in colon and liver of Big Blue rats: role of DNA adducts, strand breaks, DNA repair and oxidative stress

The contribution of oxidative stress, different types of DNA damage and expression of DNA repair enzymes in colon and liver mutagenesis induced by 2-amino-3-methylimidazo [4,5-f]quinoline (IQ) was investigated in four groups of six Big Blue rats fed diets with 0, 20, 70, and 200 mg IQ/kg for 3 weeks. There were dose-response relationships of DNA adducts (32P-postlabeling) and DNA...