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Change in weight and waist circumference and risk of colorectal cancer: results from the Melbourne Collaborative Cohort Study

Background Studies reporting the association between change in weight or body mass index during midlife and risk of colorectal cancer have found inconsistent results, and only one study to date has reported the association between change in waist circumference (a measure of central adiposity) and risk of colorectal cancer. Methods We investigated the association between risk of...

Mammographic density and risk of breast cancer by mode of detection and tumor size: a case-control study

Background Risk of screen-detected breast cancer mostly reflects inherent risk, while risk of interval cancer reflects inherent risk and risk of masking (risk of the tumor not being detected due to increased dense tissue). Therefore the predictors of whether a breast cancer is interval or screen-detected include those that predict masking. Our aim was to investigate the...

Change in Body Size and Mortality: Results from the Melbourne Collaborative Cohort Study

Background The association between change in weight or body mass index, and mortality is widely reported, however, both measures fail to account for fat distribution. Change in waist circumference, a measure of central adiposity, in relation to mortality has not been studied extensively. Methods We investigated the association between mortality and changes in directly measured...

Tools for translational epigenetic studies involving formalin-fixed paraffin-embedded human tissue: applying the Infinium HumanMethyation450 Beadchip assay to large population-based studies

BackgroundLarge population-based translational epigenetic studies are emerging due to recent technological advances that have made molecular analyses possible. For example, the Infinium HumanMethylation450 Beadchip (HM450K) has enabled studies of genome-wide methylation on a scale not previously possible. However, application of the HM450K to DNA extracted from formalin-fixed...

The impact of missing data on analyses of a time-dependent exposure in a longitudinal cohort: a simulation study

Background Missing data often cause problems in longitudinal cohort studies with repeated follow-up waves. Research in this area has focussed on analyses with missing data in repeated measures of the outcome, from which participants with missing exposure data are typically excluded. We performed a simulation study to compare complete-case analysis with Multiple imputation (MI...

Association between Melanocytic Nevi and Risk of Breast Diseases: The French E3N Prospective Cohort

Using data from the French E3N prospective cohort, Marina Kvaskoff and colleagues examine the association between number of cutaneous nevi and the risk for breast cancer. Please see later in the article for the Editors' Summary

Associations of Mammographic Dense and Nondense Areas and Body Mass Index With Risk of Breast Cancer

, Melbourne, Australia (Laura Baglietto, Kavitha Krishnan, Melissa C. Southey, Dallas R. English; Graham G. Giles); Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population ... and Global Health, University of Melbourne, Melbourne, Australia (Laura Baglietto, Kavitha Krishnan, Jennifer Stone, Carmel Apicella, Dallas R. English, John L. Hopper; Graham G. Giles); Centre for

A review of the reporting and handling of missing data in cohort studies with repeated assessment of exposure measures

BackgroundRetaining participants in cohort studies with multiple follow-up waves is difficult. Commonly, researchers are faced with the problem of missing data, which may introduce biased results as well as a loss of statistical power and precision. The STROBE guidelines von Elm et al. (Lancet, 370:1453-1457, 2007); Vandenbroucke et al. (PLoS Med, 4:e297, 2007) and the guidelines...

Population-Based Estimate of Prostate Cancer Risk for Carriers of the HOXB13 Missense Mutation G84E

The HOXB13 missense mutation G84E (rs138213197) is associated with increased risk of prostate cancer, but the current estimate of increased risk has a wide confidence interval (width of 95% confidence interval (CI) >200-fold) so the point estimate of 20-fold increased risk could be misleading. Population-based family studies can be more informative for estimating risks for rare...

Epigenome-wide association study reveals decreased average methylation levels years before breast cancer diagnosis

Background Interest in the potential of DNA methylation in peripheral blood as a biomarker of cancer risk is increasing. We aimed to assess whether epigenome-wide DNA methylation measured in peripheral blood samples obtained before onset of the disease is associated with increased risk of breast cancer. We report on three independent prospective nested case-control studies from...

The use of DNA from archival dried blood spots with the Infinium HumanMethylation450 array

Background Dried blood (Guthrie card) spots provide an efficient way to collect and store blood specimens. DNA from this source has been utilised for a number of molecular analyses including genome-wide association studies, but only few studies have tested the feasibility of using it for epigenetic applications, particularly at a genome-wide level. Results In this study, we...

Circulating prolactin and in situ breast cancer risk in the European EPIC cohort: a case-control study

Johnson 0 Sabina Rinaldi Isabelle Romieu Anne Tjnneland Anja Olsen Kim Overvad Franoise Clavel-Chapelon Laura Baglietto Heiner Boeing Antonia Trichopoulou Pagona Lagiou Dimitrios Trichopoulos Giovanna

A PALB2 mutation associated with high risk of breast cancer

Introduction As a group, women who carry germline mutations in partner and localizer of breast cancer 2 susceptibility protein (PALB2) are at increased risk of breast cancer. Little is known about by how much or whether risk differs by mutation or family history, owing to the paucity of studies of cases unselected for family history. Methods We screened 1,403 case probands for...

Baseline and lifetime alcohol consumption and risk of differentiated thyroid carcinoma in the EPIC study

Paul N Appleby Martin Almquist Julie A Schmidt Christina C Dahm Kim Overvad Anne Tjønneland Agnetha L Rostgaard-Hansen Franc¸oise Clavel-Chapelon Laura Baglietto Marie-Christine Boutron-Ruault Tilman K u

Genome-wide association study identifies multiple risk loci for renal cell carcinoma

• Google ScholarSearch for Geraldine Cancel-Tassin in:Nature Research journals • PubMed • Google ScholarSearch for Olivier Cussenot in:Nature Research journals • PubMed • Google ScholarSearch for Laura ... Baglietto in:Nature Research journals • PubMed • Google ScholarSearch for Heiner Boeing in:Nature Research journals • PubMed • Google ScholarSearch for Kay-Tee Khaw in:Nature Research journals • PubMed

Additive Interactions Between Susceptibility Single-Nucleotide Polymorphisms Identified in Genome-Wide Association Studies and Breast Cancer Risk Factors in the Breast and Prostate Cancer Cohort Consortium

Epidemiology Centre, Cancer Council Victoria, Carlton South, Victoria, Australia (Laura Baglietto, Graham G. Giles, Gianluca Severi); Centre for Molecular, Environmental, Genetic and Analytic Epidemiology ... , School of Population Health, University of Melbourne, Melbourne, Victoria, Australia (Laura Baglietto, Graham G. Giles, Gianluca Severi); Division of Cancer Prevention, National Cancer Institute, Bethesda

A Genome-Wide “Pleiotropy Scan” Does Not Identify New Susceptibility Loci for Estrogen Receptor Negative Breast Cancer

Weiderpass Aurelio Barricarte Malin Sund Mia M. Gaudet Graham Giles Melissa Southey Laura Baglietto Jenny Chang-Claude Rudolf Kaaks Federico Canzian Paolo Peterlongo, IFOM, Fondazione Istituto FIRC di

Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk

. Fasching in:Nature Research journals • PubMed • Google ScholarSearch for Laura Baglietto in:Nature Research journals • PubMed • Google ScholarSearch for Melissa C. Southey in:Nature Research journals

Fruit and Vegetable Intake and Risk of Breast Cancer by Hormone Receptor Status

Background Estrogen receptor–negative (ER−) breast cancer has few known or modifiable risk factors. Because ER− tumors account for only 15% to 20% of breast cancers, large pooled analyses are necessary to evaluate precisely the suspected inverse association between fruit and vegetable intake and risk of ER− breast cancer.