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Genetic Research and Women’s Heart Disease: a Primer

Standards Conflict of Interest Maryam Kavousi is supported by the VENI grant (91616079) from The Netherlands Organization for Health Research and Development (ZonMw). Lawrence F. Bielak and Patricia A

The relationship between diastolic blood pressure and coronary artery calcification is dependent on single nucleotide polymorphisms on chromosome 9p21.3

Background Single nucleotide polymorphisms (SNPs) within the 9p21.3 genomic region have been consistently associated with coronary heart disease (CHD), myocardial infarction, and quantity of coronary artery calcification (CAC), a marker of subclinical atherosclerosis. Prior studies have established an association between blood pressure measures and CAC. To examine mechanisms by...

Genome-Wide Association Study of Gene by Smoking Interactions in Coronary Artery Calcification

Many GWAS have identified novel loci associated with common diseases, but have focused only on main effects of individual genetic variants rather than interactions with environmental factors (GxE). Identification of GxE interactions is particularly important for coronary heart disease (CHD), a major preventable source of morbidity and mortality with strong non-genetic risk...

The Association of Coronary Artery Calcification and Carotid Artery Intima-Media Thickness With Distinct, Traditional Coronary Artery Disease Risk Factors in Asymptomatic Adults

Asymptomatic Adults Evadnie Rampersaud Lawrence F. Bielak Afshin Parsa Haiqing Shen Wendy Post Kathleen A. Ryan Patrick Donnelly John A. Rumberger Patrick F. Sheedy II Patricia A. Peyser Alan R. Shuldiner ... , Maryland (Wendy Post); Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan (Lawrence F. Bielak, Patricia A. Peyser); Department of Cardiovascular Diseases, The

Genetics of coronary artery calcification among African Americans, a meta-analysis

Background Coronary heart disease (CHD) is the major cause of death in the United States. Coronary artery calcification (CAC) scores are independent predictors of CHD. African Americans (AA) have higher rates of CHD but are less well-studied in genomic studies. We assembled the largest AA data resource currently available with measured CAC to identify associated genetic variants...

Meta-Analysis of Genome-Wide Association Studies in African Americans Provides Insights into the Genetic Architecture of Type 2 Diabetes

Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However, little is known about the genetic risk in African Americans despite the recent identification of more than 70 T2D loci primarily by genome-wide association studies (GWAS) in individuals of European ancestry. In order to investigate the genetic architecture of T2D in African Americans, the...

Genome-Wide Association of Body Fat Distribution in African Ancestry Populations Suggests New Loci

Central obesity, measured by waist circumference (WC) or waist-hip ratio (WHR), is a marker of body fat distribution. Although obesity disproportionately affects minority populations, few studies have conducted genome-wide association study (GWAS) of fat distribution among those of predominantly African ancestry (AA). We performed GWAS of WC and WHR, adjusted and unadjusted for...

Potential of Quantity of Coronary Artery Calcification to Identify New Risk Factors for Asymptomatic Atherosclerosis

The goals of this study of adults asymptomatic for coronary artery disease (CAD) were to examine the relations between established CAD risk factors and quantity of coronary artery calcification (CAC) in three arterial locations using generalized linear mixed models and to estimate the variability in quantity of CAC explained by established CAD risk factors and the variability due...