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Age at menarche and childhood body mass index as predictors of cardio-metabolic risk in young adulthood: A prospective cohort study

at years 17 and 20, and the metabolic syndrome at year 20. (DOCX) Author Contributions Conceptualization: Chi Le-Ha, Lawrence J. Beilin, Martha Hickey, Trevor A. Mori, Roger J. Hart. Formal ... analysis: Chi Le-Ha, Sally Burrows. Investigation: Chi Le-Ha, Roger J. Hart. Methodology: Chi Le-Ha, Lawrence J. Beilin, Sally Burrows, Rae-Chi Huang, Martha Hickey, Trevor A. Mori. Supervision: Lawrence

Dual Energy X-Ray Absorptiometry Compared with Anthropometry in Relation to Cardio-Metabolic Risk Factors in a Young Adult Population: Is the ‘Gold Standard’ Tarnished?

Background and Aims Assessment of adiposity using dual energy x-ray absorptiometry (DXA) has been considered more advantageous in comparison to anthropometry for predicting cardio-metabolic risk in the older population, by virtue of its ability to distinguish total and regional fat. Nonetheless, there is increasing uncertainty regarding the relative superiority of DXA and little...

Supplementation with N-3 Long-Chain Polyunsaturated Fatty Acids or Olive Oil in Men and Women with Renal Disease Induces Differential Changes in the DNA Methylation of FADS2 and ELOVL5 in Peripheral Blood Mononuclear Cells

Background Studies in animal models and in cultured cells have shown that fatty acids can induce alterations in the DNA methylation of specific genes. There have been no studies of the effects of fatty acid supplementation on the epigenetic regulation of genes in adult humans. Methods and Results We investigated the effect of supplementing renal patients with 4 g daily of either...

Modelling BMI Trajectories in Children for Genetic Association Studies

Background The timing of associations between common genetic variants and changes in growth patterns over childhood may provide insight into the development of obesity in later life. To address this question, it is important to define appropriate statistical models to allow for the detection of genetic effects influencing longitudinal childhood growth. Methods and Results...

Comparing the effects of sun exposure and vitamin D supplementation on vitamin D insufficiency, and immune and cardio-metabolic function: the Sun Exposure and Vitamin D Supplementation (SEDS) Study

D Supplementation (SEDS) Study Mica Hartley 0 Samuel Hoare 0 Fiona E Lithander Rachel E Neale Prue H Hart 1 Shelley Gorman 1 Peter Gies Jill Sherriff Ashwin Swaminathan Lawrence J Beilin Trevor A

DNA methylation of the IGF2/H19 imprinting control region and adiposity distribution in young adults

Background The insulin-like growth factor 2 (IGF2) and H19 imprinted genes control growth and body composition. Adverse in-utero environments have been associated with obesity-related diseases and linked with altered DNA methylation at the IGF2/H19 locus. Postnatally, methylation at the IGF2/H19 imprinting control region (ICR) has been linked with cerebellum weight. We aimed to...

Association of a Body Mass Index Genetic Risk Score with Growth throughout Childhood and Adolescence

Background While the number of established genetic variants associated with adult body mass index (BMI) is growing, the relationships between these variants and growth during childhood are yet to be fully characterised. We examined the association between validated adult BMI associated single nucleotide polymorphisms (SNPs) and growth trajectories across childhood. We...

Lifecourse Childhood Adiposity Trajectories Associated With Adolescent Insulin Resistance

LAWRENCE J. BEILIN C a r d i o v a s c u l a r a n d OBJECTIVE-In light of the obesity epidemic, we aimed to characterize novel childhood adiposity trajectories from birth to age 14 years and to determine

Synergy Between Adiposity, Insulin Resistance, Metabolic Risk Factors, and Inflammation in Adolescents

RAE-CHI HUANG TREVOR A. MORI PHD VALERIE BURKE JOHN NEWNHAM FIONA J. STANLEY LOUIS I. LANDAU GARTH E. KENDALL PHD WENDY H. ODDY PHD LAWRENCE J. BEILIN C a r d i o v a s c u l a r a n d OBJECTIVE

Hemodynamic Effects of Fenofibrate and Coenzyme Q10 in Type 2 Diabetic Subjects With Left Ventricular Diastolic Dysfunction

GERARD T. CHEW GERALD F. WATTS DSC TIMOTHY M.E. DAVIS DPHIL BRONWYN G.A. STUCKEY LAWRENCE J. BEILIN PETER L. THOMPSON VALERIE BURKE PHILIP J. CURRIE OBJECTIVE - To investigate the effects of

Loci affecting gamma-glutamyl transferase in adults and adolescents show age × SNP interaction and cardiometabolic disease associations

Serum gamma-glutamyl transferase (GGT) activity is a marker of liver disease which is also prospectively associated with the risk of all-cause mortality, cardiovascular disease, type 2 diabetes and cancers. We have discovered novel loci affecting GGT in a genome-wide association study (rs1497406 in an intergenic region of chromosome 1, P = 3.9 × 10−8; rs944002 in C14orf73 on...

Regulatory Effects of HMG CoA Reductase Inhibitor and Fish Oils on Apolipoprotein B-100 Kinetics in Insulin-Resistant Obese Male Subjects With Dyslipidemia

Hepatic accumulation of lipid substrates perturbs apolipoproteinB-100 (apoB) metabolism in insulin-resistant, obese subjects and may account for increased risk of cardiovascular disease. In a placebo-controlled trial, we examined the independent and combined effects of decreasing cholesterol synthesis with atorvastatin (40 mg/day) and triglyceride synthesis with fish oils (4 g...

Docosahexaenoic Acid But Not Eicosapentaenoic Acid Increases LDL Particle Size in Treated Hypertensive Type 2 Diabetic Patients

issue. RICHARD J. WOODMAN, MMEDSCI1 TREVOR A. MORI, PHD1 VALERIE BURKE, MD1 IAN B. PUDDEY, MD1 GERALD F. WATTS, MD, PHD1 JAMES D. BEST, MD2 LAWRENCE J. BEILIN, MD1 From the 1Department of Medicine

Association of Genetic Loci With Glucose Levels in Childhood and Adolescence: A Meta-Analysis of Over 6,000 Children

Claudia Langenberg Adam Barker Stephen J. Sharp Nicholas J. Timpson Nabila Bouatia-Naji Nicole M. Warrington Stavroula Kanoni Lawrence J. Beilin Soren Brage Panos Deloukas David M. Evans Anders

Genome-Wide Association Study to Identify Common Variants Associated with Brachial Circumference: A Meta-Analysis of 14 Cohorts

. Elliott Kalliope Panoutsopoulou Ioanna Tachmazidou Eva Albrecht Stefania Bandinelli Lawrence J. Beilin Murielle Bochud Gemma Cadby Florian Ernst David M. Evans Caroline Hayward Andrew A. Hicks Jennifer