at years 17 and 20, and the metabolic syndrome at year 20. (DOCX) Author Contributions Conceptualization: Chi Le-Ha, Lawrence J. Beilin, Martha Hickey, Trevor A. Mori, Roger J. Hart. Formal ... analysis: Chi Le-Ha, Sally Burrows. Investigation: Chi Le-Ha, Roger J. Hart. Methodology: Chi Le-Ha, Lawrence J. Beilin, Sally Burrows, Rae-Chi Huang, Martha Hickey, Trevor A. Mori. Supervision: Lawrence
There are differences in the prevalence and severity of diseases between males, females not taking hormonal contraceptives (non-HC females) and females taking hormonal contraceptives (HC females). The aim of this study was to identify sex-specific differences in the metabolome and its relation to components of the metabolic syndrome in a young adult population. The subjects...
Background and Aims Assessment of adiposity using dual energy x-ray absorptiometry (DXA) has been considered more advantageous in comparison to anthropometry for predicting cardio-metabolic risk in the older population, by virtue of its ability to distinguish total and regional fat. Nonetheless, there is increasing uncertainty regarding the relative superiority of DXA and little...
Background Studies in animal models and in cultured cells have shown that fatty acids can induce alterations in the DNA methylation of specific genes. There have been no studies of the effects of fatty acid supplementation on the epigenetic regulation of genes in adult humans. Methods and Results We investigated the effect of supplementing renal patients with 4 g daily of either...
Background The timing of associations between common genetic variants and changes in growth patterns over childhood may provide insight into the development of obesity in later life. To address this question, it is important to define appropriate statistical models to allow for the detection of genetic effects influencing longitudinal childhood growth. Methods and Results...
Background The insulin-like growth factor 2 (IGF2) and H19 imprinted genes control growth and body composition. Adverse in-utero environments have been associated with obesity-related diseases and linked with altered DNA methylation at the IGF2/H19 locus. Postnatally, methylation at the IGF2/H19 imprinting control region (ICR) has been linked with cerebellum weight. We aimed to...
The insulin-like growth factor 2 (IGF2) and H19 imprinted genes control growth and body composition. Adverse in-utero environments have been associated with obesity-related diseases and linked with altered DNA methylation at the IGF2/H19 locus. Postnatally, methylation at the IGF2/H19 imprinting control region (ICR) has been linked with cerebellum weight. We aimed to investigate...
Background While the number of established genetic variants associated with adult body mass index (BMI) is growing, the relationships between these variants and growth during childhood are yet to be fully characterised. We examined the association between validated adult BMI associated single nucleotide polymorphisms (SNPs) and growth trajectories across childhood. We...
D Supplementation (SEDS) Study Mica Hartley 0 Samuel Hoare 0 Fiona E Lithander Rachel E Neale Prue H Hart 1 Shelley Gorman 1 Peter Gies Jill Sherriff Ashwin Swaminathan Lawrence J Beilin Trevor A
Scholar Search for Ashwin Swaminathan in:PubMed • Google Scholar Search for Lawrence J Beilin in:PubMed • Google Scholar Search for Trevor A Mori in:PubMed • Google Scholar Search for Laura King
GERARD T. CHEW GERALD F. WATTS DSC TIMOTHY M.E. DAVIS DPHIL BRONWYN G.A. STUCKEY LAWRENCE J. BEILIN PETER L. THOMPSON VALERIE BURKE PHILIP J. CURRIE OBJECTIVE - To investigate the effects of
RAE-CHI HUANG TREVOR A. MORI PHD VALERIE BURKE JOHN NEWNHAM FIONA J. STANLEY LOUIS I. LANDAU GARTH E. KENDALL PHD WENDY H. ODDY PHD LAWRENCE J. BEILIN C a r d i o v a s c u l a r a n d OBJECTIVE
LAWRENCE J. BEILIN C a r d i o v a s c u l a r a n d OBJECTIVE-In light of the obesity epidemic, we aimed to characterize novel childhood adiposity trajectories from birth to age 14 years and to determine
Hepatic accumulation of lipid substrates perturbs apolipoproteinB-100 (apoB) metabolism in insulin-resistant, obese subjects and may account for increased risk of cardiovascular disease. In a placebo-controlled trial, we examined the independent and combined effects of decreasing cholesterol synthesis with atorvastatin (40 mg/day) and triglyceride synthesis with fish oils (4 g...
issue. RICHARD J. WOODMAN, MMEDSCI1 TREVOR A. MORI, PHD1 VALERIE BURKE, MD1 IAN B. PUDDEY, MD1 GERALD F. WATTS, MD, PHD1 JAMES D. BEST, MD2 LAWRENCE J. BEILIN, MD1 From the 1Department of Medicine
, Norwegian Institute of Public Health, Oslo, Norway Gunn Marit Aasvang Medical School, University of Western Australia, Perth, Australia Lawrence J. Beilin & Trevor A. Mori Department of Translational ... search for this author in PubMed Google Scholar Gunn Marit Aasvang View author publications You can also search for this author in PubMed Google Scholar Lawrence J. Beilin View author publications
Serum gamma-glutamyl transferase (GGT) activity is a marker of liver disease which is also prospectively associated with the risk of all-cause mortality, cardiovascular disease, type 2 diabetes and cancers. We have discovered novel loci affecting GGT in a genome-wide association study (rs1497406 in an intergenic region of chromosome 1, P = 3.9 × 10−8; rs944002 in C14orf73 on...
Claudia Langenberg Adam Barker Stephen J. Sharp Nicholas J. Timpson Nabila Bouatia-Naji Nicole M. Warrington Stavroula Kanoni Lawrence J. Beilin Soren Brage Panos Deloukas David M. Evans Anders
Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, we find that DNA methylation in neonatal blood is associated with birthweight at 914 sites, with a...