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Application of Metabolomics in the Study of Natural Products

LC–MS-based metabolomics could have a major impact in the study of natural products, especially in its metabolism, toxicity and activity. This review highlights recent applications of metabolomics approach in the study of metabolites and toxicity of natural products, and the understanding of their effects on various diseases. Metabolomics has been employed to study the in vitro...

A large and aggressive fibromatosis in the axilla: a rare case report and review of the literature

A large and aggressive fibromatosis in the axilla: a rare case report and review of the literature Mingyue Duan,1 Hua Xing,1 Keren Wang,1 Chunbo Niu,2 Chengwei Jiang,2 Lijuan Zhang,1 Shereen Ezzat,3 Le Zhang1 1Department of Breast Surgery, China-Japan Union Hospital, Jilin University, Changchun, Jilin, People’s Republic of China; 2Department of Pathology, China-Japan Union...

Can Preoperative Examination Help Choose the Best Surgical Procedure in Gastric Cancer?

April 2018 Academic Editor: Kerstin Schütte Copyright © 2018 Jia-Le Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted

Representative Stress-Strain Curve by Spherical Indentation on Elastic-Plastic Materials

Tensile stress-strain curve of metallic materials can be determined by the representative stress-strain curve from the spherical indentation. Tabor empirically determined the stress constraint factor (stress CF), ψ, and strain constraint factor (strain CF), β, but the choice of value for ψ and β is still under discussion. In this study, a new insight into the relationship between...

Hsa_circ_0001859 Regulates ATF2 Expression by Functioning as an MiR-204/211 Sponge in Human Rheumatoid Arthritis

Background. circRNAs are part of the competitive endogenous RNA network, which putatively function as miRNA sponges and play a crucial role in the development of numerous diseases. However, studies of circRNAs in rheumatoid arthritis (RA) disease are limited. This work aims to identify the expression pattern of circRNAs in synovial tissues and their inflammatory regulation...

Neural Vascular Mechanism for the Cerebral Blood Flow Autoregulation after Hemorrhagic Stroke

, China Correspondence should be addressed to Le Zhang; nc.ude.uws@qclgnahz and Yujie Chen; moc.liamxof@6886nehceijuy Received 30 June 2017; Accepted 11 September 2017; Published 26 September 2017

Treatment adherence and disease burden of individuals with rheumatic diseases admitted as outpatients to a large rheumatology center in Shanghai, China

Treatment adherence and disease burden of individuals with rheumatic diseases admitted as outpatients to a large rheumatology center in Shanghai, China Le Zhang,1 Guo Hong Lu,1 Shuang Ye,2 Bin Wu,1

Over 19 W Single-Mode 1545 nm Er,Yb Codoped All-Fiber Laser

We report a high-power cladding-pumped Er,Yb codoped all-fiber laser with truly single transverse mode output. The fiber laser is designed to operate at 1545 nm by the use of a pair of fiber Bragg gratings (FBGs) to lock and narrow the output spectrum, which can be very useful in generating the eye-safe ~1650 nm laser emission through the Stimulated Raman Scattering (SRS) in...

Transcriptomic meta-analysis identifies gene expression characteristics in various samples of HIV-infected patients with nonprogressive disease

A small proportion of HIV-infected patients remain clinically and/or immunologically stable for years, including elite controllers (ECs) who have undetectable viremia (<50 copies/ml) and long-term nonprogressors (LTNPs) who maintain normal CD4+ T cell counts for prolonged periods (>10 years). However, the mechanism of nonprogression needs to be further resolved. In this study, a...

Molecular Mutations and Their Cooccurrences in Cytogenetically Normal Acute Myeloid Leukemia

Adult acute myeloid leukemia (AML) clinically is a disparate disease that requires intensive treatments ranging from chemotherapy alone to allogeneic hematopoietic cell transplantation (allo-HCT). Historically, cytogenetic analysis has been a useful prognostic tool to classify patients into favorable, intermediate, and unfavorable prognostic risk groups. However, the intermediate...

Additive effects of cherlerythrine chloride combination with erlotinib in human non-small cell lung cancer cells

Several studies implicate that lung cancer progression is governed by the interaction between epidermal growth factor receptor (EGFR) signaling and protein kinase C (PKC) pathways. Combined the targeting of EGFR and PKC may have an additive or synergistic effects in lung cancer treatment. The aim of this study is to explore the potential utility by inhibiting these two pathways...

Hydrogen: efficient promoter for PNP/Cr(III)/MAO catalyzed ethylene tetramerization toward 1-octene

The effect of hydrogen addition on the catalytic activity and product selectivity of PNP/Cr(III)/MAO catalytic systems for ethylene tetramerization was investigated. The results showed that the catalytic activity could be increased twice and the polymer production could be reduced efficiently through hydrogen addition. It could be inferred from the analysis and characterization...

Multi-Scale Agent-Based Multiple Myeloma Cancer Modeling and the Related Study of the Balance between Osteoclasts and Osteoblasts

Research Background Currently, multiple myeloma is the second most common hematological malignancy in the U.S., constituting 1% of all cancers. With conventional treatment, the median survival time is typically 3–4 years, although it can be extended to 5–7 years or longer with advanced treatments. Recent research indicated that an increase in osteoclast (OC) activity is often...

Development of an Agent-Based Model (ABM) to Simulate the Immune System and Integration of a Regression Method to Estimate the Key ABM Parameters by Fitting the Experimental Data

Agent-based models (ABM) and differential equations (DE) are two commonly used methods for immune system simulation. However, it is difficult for ABM to estimate key parameters of the model by incorporating experimental data, whereas the differential equation model is incapable of describing the complicated immune system in detail. To overcome these problems, we developed an...

A meta-analysis of combination therapy versus single-agent therapy in anthracycline- and taxane-pretreated metastatic breast cancer: results from nine randomized Phase III trials

,* Xiaobo Wu,3,* Chun Hu,1,2 Zhiying Zhang,4 Le Zhang,1,2 Shujing Liang,1,2 Yingchun Xu,5 Fengchun Zhang1,2 1Department of Oncology, Suzhou Kowloon Hospital, Shanghai Jiaotong University School of Medicine

Clinical and Virological Characteristics of Chronic Hepatitis B Patients with Coexistence of HBsAg and Anti-HBs

Coexistence of hepatitis B surface antigen (HBsAg) and antibody against HBsAg (anti-HBs) comprises an atypical serological profile in patients with chronic hepatitis B virus (HBV) infection. In this study, in total 94 patients with coexisting HBsAg and anti-HBs and 94 age- and sex-matched patients with positive HBsAg were characterized by quantitatively measuring HBsAg and HBV...

An Analysis of Peer-Reviewed Scores and Impact Factors with Different Citation Time Windows: A Case Study of 28 Ophthalmologic Journals

Background An important attribute of the traditional impact factor was the controversial 2-year citation window. So far, several scholars have proposed using different citation time windows for evaluating journals. However, there is no confirmation whether a longer citation time window would be better. How did the journal evaluation effects of 3IF, 4IF, and 6IF comparing with 2IF...

Exosome-delivered EGFR regulates liver microenvironment to promote gastric cancer liver metastasis

Clinical Research Center for Cancer, Tianjin 300060, ChinaHaiyang Zhang, Ting Deng, Rui Liu, Ming Bai, Likun Zhou, Xia Wang, Shuang Li, Xinyi Wang, Haiou Yang, Tao Ning, Dingzhi Huang, Hongli Li, Le Zhang ... ScholarSearch for Hongli Li in:Nature Research journals • PubMed • Google ScholarSearch for Le Zhang in:Nature Research journals • PubMed • Google ScholarSearch for Guoguang Ying in:Nature Research journals

Single Nucleotide Polymorphisms in P2X7 Gene Are Associated with Serum Immunoglobulin G Responses to Mycobacterium tuberculosis in Tuberculosis Patients

Objective. Our study investigated the association between single nucleotide polymorphisms (SNPs) in P2X7 gene and serum immunoglobulin G (IgG) responses to mycobacterium tuberculosis (MTB) in TB patients. Methods. A total of 103 TB patients were enrolled as case group and 87 healthy individuals at same geographical region as control group. The SNP detection of 1513A>C and -762T>C...