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24 papers found.
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Low-dose strontium stimulates osteogenesis but high-dose doses cause apoptosis in human adipose-derived stem cells via regulation of the ERK1/2 signaling pathway

Background Strontium is a widely used anti-osteoporotic agent due to its dual effects on inhibiting bone resorption and stimulating bone formation. Thus, we studied the dose response of strontium on osteo-inductive efficiency in human adipose-derived stem cells (hASCs). Method Qualitative alkaline phosphatase (ALP) staining, quantitative ALP activity, Alizarin Red staining, real...

High light stress triggers distinct proteomic responses in the marine diatom Thalassiosira pseudonana

Background Diatoms are able to acclimate to frequent and large light fluctuations in the surface ocean waters. However, the molecular mechanisms underlying these acclimation responses of diaotms remain elusive. Results In this study, we investigated the mechanism of high light protection in marine diatom Thalassiosira pseudonana using comparative proteomics in combination with...

High light stress triggers distinct proteomic responses in the marine diatom Thalassiosira pseudonana

Background Diatoms are able to acclimate to frequent and large light fluctuations in the surface ocean waters. However, the molecular mechanisms underlying these acclimation responses of diaotms remain elusive. Results In this study, we investigated the mechanism of high light protection in marine diatom Thalassiosira pseudonana using comparative proteomics in combination with...

Statefinder hierarchy exploration of the extended Ricci dark energy

We apply the statefinder hierarchy plus the fractional growth parameter to explore the extended Ricci dark energy (ERDE) model, in which there are two independent coefficients \(\alpha \) and \(\beta \). By adjusting them, we plot evolution trajectories of some typical parameters, including the Hubble expansion rate E, deceleration parameter q, the third- and fourth-order...

Comparing holographic dark energy models with statefinder

Jing-Lei Cui 0 Jing-Fei Zhang 0 0 Department of Physics, College of Sciences, Northeastern University , Shenyang 110004, China We apply the statefinder diagnostic to the holographic dark energy

Restoring the Secretory Function of Irradiation-Damaged Salivary Gland by Administrating Deferoxamine in Mice

Objectives One of the major side effects of radiotherapy for treatments of the head and neck cancer is the radiation-induced dysfunction of salivary glands. The aim of the present study is to investigate the efficacy of deferoxamine (DFO) to restore the secretory function of radiation-damaged salivary glands in mice. Methods DFO (50 mg/kg/d) was administered intraperitoneally in...

Subcutaneous Construction of Engineered Adipose Tissue with Fat Lobule-Like Structure Using Injectable Poly-Benzyl-L-Glutamate Microspheres Loaded with Adipose-Derived Stem Cells

Porous microcarriers were fabricated from synthesized poly(γ-benzyl-L-glutamate) (PBLG) polymer to engineer adipose tissue with lobule-like structure via the injectable approach. The adipogenic differentiation of human adipose-derived stem cells (hASCs) seeded on porous PBLG microcarriers was determined by adipogenic gene expression and glycerol-3-phosphate dehydrogenase enzyme...

Molecular characteristics and evolutionary analysis of a very virulent infectious bursal disease virus

Infectious bursal disease virus (IBDV) poses a significant threat to the poultry industry. Viral protein 2 (VP2), the major structural protein of IBDV, has been subjected to frequent mutations that have imparted tremendous genetic diversity to the virus. To determine how amino acid mutations may affect the virulence of IBDV, we built a structural model of VP2 of a very virulent...

Diagnosing holographic dark energy models with statefinder hierarchy

We apply a series of null diagnostics based on the statefinder hierarchy to diagnose different holographic dark energy models including the original holographic dark energy, the new holographic dark energy, the new agegraphic dark energy, and the Ricci dark energy models. We plot the curves of statefinders \(S^{(1)}_3\) and \(S^{(1)}_4\) versus redshift \(z\) and the evolutionary...

Development and evaluation of an electropositive wellbore stabilizer with flexible adaptability for drilling strongly hydratable shales

In order to overcome serious instability problems in hydratable shale formations, a novel electropositive wellbore stabilizer (EPWS) was prepared by a new approach. It has good colloidal stability, particle size distribution, compatibility, sealing property, and flexible adaptability. A variety of methods including measurements of particle size, Zeta potential, colloidal...

Revisiting the holographic dark energy in a non-flat universe: alternative model and cosmological parameter constraints

We propose an alternative model for the holographic dark energy in a non-flat universe. This new model differs from the previous one in that the IR length cutoff \(L\) is taken to be exactly the event horizon size in a non-flat universe, which is more natural and theoretically/conceptually concordant with the model of holographic dark energy in a flat universe. We constrain the...

The Graft of Autologous Adipose-Derived Stem Cells in the Corneal Stromal after Mechanic Damage

This study was designed to explore the feasibility of using autologous rabbit adipose derived stem cells (rASCs) as seed cells and polylactic-co-glycolic acid (PLGA) as a scaffold for repairing corneal stromal defects. rASCs isolated from rabbit nape adipose tissue were expanded and seeded on a PLGA scaffold to fabricate cell-scaffold constructs. After 1 week of cultivation in...

Monitoring Pancreatic Carcinogenesis by the Molecular Imaging of Cathepsin E In Vivo Using Confocal Laser Endomicroscopy

The monitoring of pancreatic ductal adenocarcinoma (PDAC) in high-risk populations is essential. Cathepsin E (CTSE) is specifically and highly expressed in PDAC and pancreatic intraepithelial neoplasias (PanINs), and its expression gradually increases along with disease progression. In this study, we first established an in situ 7,12-dimethyl-1,2-benzanthracene (DMBA)-induced rat...

Sulphate attack resistance of high-performance concrete under compressive loading

In this paper, an experimental study on the sulphate attack resistance of high-performance concrete (HPC) with two different water-to-binder ratios (w/b) under compressive loading is presented. The sulphate concentration, compressive strength, and the mass change in the HPC specimens were determined for immersion in a Na2SO4 solution over different durations under external...

Local Injection of Deferoxamine Improves Neovascularization in Ischemic Diabetic Random Flap by Increasing HIF-1α and VEGF Expression

Li 0 Lei Cui 0 Michael E. Boulton, Indiana University College of Medicine, United States of America 0 1 Department of Plastic and Reconstructive Surgery , Shanghai 9 Background: Although the systemic

Hepatitis B Virus Polymerase Suppresses NF-κB Signaling by Inhibiting the Activity of IKKs via Interaction with Hsp90β

Nuclear factor-κB (NF-κB) plays a central role in the regulation of diverse biological processes, including immune responses, development, cell growth, and cell survival. To establish persistent infection, many viruses have evolved strategies to evade the host’s antiviral immune defenses. In the case of hepatitis B virus (HBV), which can cause chronic infection in the liver...

Compact Conformations of Human Protein Disulfide Isomerase

Protein disulfide isomerase (PDI) composed of four thioredoxin-like domains a, b, b', and a', is a key enzyme catalyzing oxidative protein folding in the endoplasmic reticulum. Large scale molecular dynamics simulations starting from the crystal structures of human PDI (hPDI) in the oxidized and reduced states were performed. The results indicate that hPDI adopts more compact...

Clodronate-superparamagnetic iron oxide-containing liposomes attenuate renal injury in rats with severe acute pancreatitis

. Compliance with ethics guidelines Sheng-chun DANG, Yan-hua ZENG, Ping-jiang WANG, Bao-ding CHEN, Rong-fang CHEN, Arun KUMAR SINGH, Pankaj KUMAR, Shu FENG, Lei CUI, Hao WANG, and Jian-xin ZHANG declare that

FPGS rs1544105 polymorphism is associated with treatment outcome in pediatric B-cell precursor acute lymphoblastic leukemia

Background Folypolyglutamate synthase (FPGS) catalyzes the polyglutamation of folates and antifolates, such as methotrexate (MTX), to produce highly active metabolites. FPGS tag SNP rs1544105C > T is located in the gene promoter. The aim of the present study was to investigate the impact of rs1544105 polymorphism on the treatment outcome in pediatric B-cell precursor acute...

Differentiation of human multipotent dermal fibroblasts into islet-like cell clusters

Background We have previously obtained a clonal population of cells from human foreskin that is able to differentiate into mesodermal, ectodermal and endodermal progenies. It is of great interest to know whether these cells could be further differentiated into functional insulin-producing cells. Results Sixty-one single-cell-derived dermal fibroblast clones were established from...