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Bus-OLAP: A Data Management Model for Non-on-Time Events Query Over Bus Journey Data

Increasing the on-time rate of bus service can prompt the people’s willingness to travel by bus, which is an effective measure to mitigate the city traffic congestion. Performing queries on the bus arrival can be used to identify and analyze various kinds of non-on-time events that happened during the bus journey, which is helpful for detecting the factors of delaying events, and...

Phylogeography and conservation genetics of the rare and relict Bretschneidera sinensis (Akaniaceae)

. Methodology: Mei-Na Wang. Resources: Qi Qiao, Zheng-Feng Wang, Zhong-Chao Li. Validation: Elizabeth A. Zimmer. Visualization: Lei Duan. Writing ± review & editing: Lei Duan. 14 / 17 18. 19. Wang YL, Li X

Hedysarum L. (Fabaceae: Hedysareae) Is Not Monophyletic – Evidence from Phylogenetic Analyses Based on Five Nuclear and Five Plastid Sequences

The legume family (Fabaceae) exhibits a high level of species diversity and evolutionary success worldwide. Previous phylogenetic studies of the genus Hedysarum L. (Fabaceae: Hedysareae) showed that the nuclear and the plastid topologies might be incongruent, and the systematic position of the Hedysarum sect. Stracheya clade was uncertain. In this study, phylogenetic...

Revision of series Gravesiana (Adiantum L.) based on morphological characteristics, spores and phylogenetic analyses

Since the adoption of some ambiguous and quantitative characters in Flora Republicae Popularis Sinicae 3(1), species identifications of the series Gravesiana have been in disarray, requiring clarification. Two hundred and fifty-nine individuals from 47 different populations were collected for the estimation of morphological characters and phylogenetic analyses. Spores of 26...

A quantitative analysis of hydraulic interaction processes in stream-aquifer systems

, Xian, 710054, P.R. ChinaWenke Wang, Yaqian Zhao, Junting Li, Lei Duan & Zhoufeng WangEarth and Environmental Sciences Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USAZhenxue DaiUCD ... • Google ScholarSearch for Yaqian Zhao in:Nature Research journals • PubMed • Google ScholarSearch for Junting Li in:Nature Research journals • PubMed • Google ScholarSearch for Lei Duan in:Nature Research

G-quadruplex and G-rich sequence stimulate Pif1p-catalyzed downstream duplex DNA unwinding through reducing waiting time at ss/dsDNA junction

Alternative DNA structures that deviate from B-form double-stranded DNA such as G-quadruplex (G4) DNA can be formed by G-rich sequences that are widely distributed throughout the human genome. We have previously shown that Pif1p not only unfolds G4, but also unwinds the downstream duplex DNA in a G4-stimulated manner. In the present study, we further characterized the G4...

Reproductive factors and the risk of triple-negative breast cancer in white women and African-American women: a pooled analysis

Eunjung Lee Kayo Togawa 0 Lei Duan 0 Yani Lu 0 Kathleen E. Malone Polly A. Marchbanks Jill A. McDonald Michael S. Simon Suzanne G. Folger Jane Sullivan-Halley 0 Dennis M. Deapen Michael F. Press Leslie

The Bacteroides sp. 3_1_23 Pif1 protein is a multifunctional helicase

ScPif1 DNA helicase is the prototypical member of a 5′-to-3′ helicase superfamily conserved from bacteria to human and plays various roles in the maintenance of genomic homeostasis. While many studies have been performed with eukaryotic Pif1 helicases, including yeast and human Pif1 proteins, the potential functions and biochemical properties of prokaryotic Pif1 helicases remain...

Crystal structures of the BsPif1 helicase reveal that a major movement of the 2B SH3 domain is required for DNA unwinding

Pif1 helicases are ubiquitous members of the SF1B family and are essential for maintaining genome stability. It was speculated that Pif1-specific motifs may fold in specific structures, conferring distinct activities upon it. Here, we report the crystal structures of the Pif1 helicase from Bacteroides spp with and without adenosine triphosphate (ATP) analog/ssDNA. BsPif1 shares...

A Scan Statistic for Binary Outcome Based on Hypergeometric Probability Model, with an Application to Detecting Spatial Clusters of Japanese Encephalitis

As a useful tool for geographical cluster detection of events, the spatial scan statistic is widely applied in many fields and plays an increasingly important role. The classic version of the spatial scan statistic for the binary outcome is developed by Kulldorff, based on the Bernoulli or the Poisson probability model. In this paper, we apply the Hypergeometric probability model...

Progress and prospects in stem cell therapy

Biophysics, Chinese Academy of Sciences, Beijing 100101, ChinaXiu-ling Xu, Hui-ze Pan, Shun-lei Duan, Zhi-chao Ding, Guo-hong Yuan, Jing Qu, Hai-chen Zhang & Guang-hui LiuDepartment of Molecular and Cellular ... in:Nature Research journals • PubMed • Google ScholarSearch for Hui-ze Pan in:Nature Research journals • PubMed • Google ScholarSearch for Shun-lei Duan in:Nature Research journals • PubMed • Google

Menopausal Hormone Therapy Use and Risk of Invasive Colon Cancer: The California Teachers Study

Cancer Etiology, Department of Population Sciences, Beckman Research Institute, City of Hope National Medical Center, Duarte, California (Katherine DeLellis Henderson, Lei Duan, Jane SullivanHalley, Huiyan

Pregnancy-related factors and the risk of breast carcinoma in situ and invasive breast cancer among postmenopausal women in the California Teachers Study cohort

Introduction Although pregnancy-related factors such as nulliparity and late age at first full-term pregnancy are well-established risk factors for invasive breast cancer, the roles of these factors in the natural history of breast cancer development remain unclear. Methods Among 52,464 postmenopausal women participating in the California Teachers Study (CTS), 624 were diagnosed...

Enhancement of Antimycobacterial Activity of Macrophages by Stabilization of Inner Mitochondrial Membrane Potential

Infection of human macrophages with Mycobacterium tuberculosis leads to cell death that, depending on the M. tuberculosis strain, time course, and multiplicity of infection, may have predominant features of apoptosis or necrosis. A key feature of infection-induced necrosis is mitochondrial damage characterized by an irreversible increase in the mitochondrial permeability...

Direct reprogramming of porcine fibroblasts to neural progenitor cells

, Ting-Ting Yuan, Guo-Hong Yuan, Li-Na Sui, Di Guan, Shun-Lei Duan, Hui-Ze Pan, Ping Wang, Xi-Ping Zhu, Nuria Montserrat, Ming Li, Rui-Jun Bai, Lin Liu, Juan Carlos Izpisua Belmonte, and Guang-Hui Liu