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A cross-sectional study of inpatients with late stage of dementia in Southeast China and the associations between biochemical parameters and apolipoprotein E genotypes

A cross-sectional study of inpatients with late stage of dementia in Southeast China and the associations between biochemical parameters and apolipoprotein E genotypes Bin Jiang,1,2,* Xue-Ping Zhang,3,* Mei-Fang Chen,3 Zheng Wang,3 Ming-Xue Zhao,3 Bin-Hua Chen,3 Hong-Lei Li1 1Department of Neurology and Research Center of Neurology, The Second Affiliated Hospital of Zhejiang...

Myeloperoxidase mediated HDL oxidation and HDL proteome changes do not contribute to dysfunctional HDL in Chinese subjects with coronary artery disease

Vachaparampil Mathew, Haiyi Yu, Lei Li, Liyun He, Wei Gao, Xiaodan Liu, Yanhong Guo, Jaeman Byun, Jifeng Zhang, Y. Eugene Chen. Formal analysis: Guisong Wang, Anna Vachaparampil Mathew, Haiyi Yu, Lei Li, Liyun ... . 13 / 17 Methodology: Lei Li, Yanhong Guo, Jaeman Byun. Project administration: Guisong Wang, Anna Vachaparampil Mathew, Haiyi Yu, Y. Eugene Chen, Subramaniam Pennathur. Resources: Guisong Wang

ERK inhibition promotes neuroectodermal precursor commitment by blocking self-renewal and primitive streak formation of the epiblast

Background Pluripotent stem cells hold great promise for regenerative medicine. However, before clinical application, reproducible protocols for pluripotent stem cell differentiation should be established. Extracellular signal-regulated protein kinase (ERK) signaling plays a central role for the self-renewal of epiblast stem cells (EpiSCs), but its role for subsequent germ layer...

The dose of HBV genome contained plasmid has a great impact on HBV persistence in hydrodynamic injection mouse model

Hydrodynamic injection (HI) of hepatitis B virus (HBV) mouse model is an useful tool for HBV related research in vivo. However, only 40% of C57/BL6 mice injected with 10 μg HBV genome contained plasmid (pAAV-HBV1.2), serum HBsAg more than 6 months and none of the BALB/c mice injected with 10 μg pAAV-HBV1.2 plasmid DNA, serum HBsAg positive more than 4 weeks in the previous study...

B-cell-specific Moloney murine leukemia virus integration site 1: potential stratification factor and therapeutic target for epithelial ovarian cancer [Corrigendum]

B-cell-specific Moloney murine leukemia virus integration site 1: potential stratification factor and therapeutic target for epithelial ovarian cancer [Corrigendum] Zhao Q, Gui T, Qian Q, Li L, Shen K. OncoTargets and Therapy. 2016;9:5203–5208. On page 5207, right column, the Acknowledgement section was not included. It should have been:AcknowledgmentsThis study was supported by...

Lactate dehydrogenase and creatine kinase as poor prognostic factors in lung cancer: A retrospective observational study

: Huairong Tang, Weimin Li, Li Zhang. Data curation: Lei Liu, Ying He, Ge Ge, Lei Li, Ping Zhou, Yihan Zhu, Yan Huang. Formal analysis: Lei Liu. Investigation: Ying He. Methodology: Lei Liu, Lei Li, Ping

Bioabsorbable self-retaining PLA/nano-sized β-TCP cervical spine interbody fusion cage in goat models: an in vivo study

-Ren Wang,1 Yi-Qun Ma,1 Xiang-Qian Li,1 Xi-Lei Li,1 Jian Dong1 1Department of Orthopaedic Surgery, Zhongshan Hospital, 2Department of Orthopaedic Surgery, Minhang Hospital, Fudan University, Shanghai

GnRH-mediated olfactory and visual inputs promote mating-like behaviors in male zebrafish

The engagement of sexual behaviors is regulated by a number of factors which include gene expression, hormone circulation, and multi-sensory information integration. In zebrafish, when a male and a female are placed in the same container, they show mating-like behaviors regardless of whether they are kept together or separated by a net. No mating-like behaviors are observed when...

Association of Apolipoprotein C3 Genetic Polymorphisms with the Risk of Ischemic Stroke in the Northern Chinese Han Population

The apolipoprotein C3 (APOC3) gene, which is a member of the APOA1/C3/A4/A5 gene cluster, plays a crucial role in lipid metabolism. Dyslipidemia is an important risk factor for ischemic stroke. In the present study, we performed a hospital-based case—control study of 895 ischemic stroke patients and 883 control subjects to examine the effects of four APOC3 single nucleotide...

Assessment of the toxicity of crude oil in Sinonovacula constricta clams

This study is aimed at investigating the toxic effects on clams (Sinonovacula constricta) exposed to selected concentrations of individual crude oil: water accommodated fraction (WAF) and chemically enhanced (or dispersed) WAF (CEWAF). For this purpose, a study was performed on clams exposed to 0.04 mg L-1 and 0.01 mg L-1 WAF and CEWAF for 15 days, using parameters of antioxidant...

Delivery of miR-375 and doxorubicin hydrochloride by lipid-coated hollow mesoporous silica nanoparticles to overcome multiple drug resistance in hepatocellular carcinoma

Yong Liu,1 Weigang Yuan,1 Tan Yang,1 Jia You,1 Xingxing He,2 Robert J Lee,3 Lei Li,1 Chuanrui Xu1 1School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, 2Institute of

Initial response of fish trophic niche to hydrological alteration in the upstream of Three Gorges Dam

Introduction Damming is one of the dramatic impacts to river food webs due to habitat fragmentation and changes in the hydrological regimes. The world’s largest dam, the Three Gorges Dam (TGD), has been constructed in the middle of Yangtze River since 2003. The objective of this study was to understand the effects of altered hydrological regime on the trophic structure of fish...

Tetrandrine inhibits migration and invasion of human renal cell carcinoma by regulating Akt/NF-κB/MMP-9 signaling

Renal cell carcinoma (RCC) is known as one of the most lethal malignancies in the urological system because of its high incidence of metastasis. Tetrandrine (Tet), a traditional Chinese herbal medicine, exerts a potent anti-cancer effect in a variety of cancer cells. However, the anti-metastatic effect of Tet and its possible mechanism in RCC is still unclear. The present study...

An abnormal displacement change during holding period in nanoindentation tests on zirconia dental ceramic

LI 1 Danyu JIANG 1 0 Department of Stomatology, Nanfang Hospital, Southern Medical University , Guangzhou 510515 , China 1 Analysis and Testing Center for Inorganic Materials, the State Key Laboratory

A mesophilic anaerobic digester for treating food waste: process stability and microbial community analysis using pyrosequencing

Background Anaerobic digesters become unstable when operated at a high organi c loading rate (OLR). Investigating the microbial community response to OLR disturbance is helpful for achieving efficient and stable process operation. However, previous studies have only focused on community succession during different process stages. How does community succession influence process...