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Ergodic Channel Capacity Analysis of Downlink in the Hybrid Satellite-Terrestrial Cooperative System

. His current research interest is satellite mobile communication networks. Lei Xie received the B.S. degree in Electronic Engineering, M.S. and Ph.D. degrees in Communications and Information Systems

Insights into the binding mode of MEK type-III inhibitors. A step towards discovering and designing allosteric kinase inhibitors across the human kinome

Protein kinases are critical drug targets for treating a large variety of human diseases. Type-III kinase inhibitors have attracted increasing attention as highly selective therapeutics. Thus, understanding the binding mechanism of existing type-III kinase inhibitors provides useful insights into designing new type-III kinase inhibitors. In this work, we have systematically studied ...

Guest Editorial: Immersive Audio/Visual Systems

the near future. Lei Xie received the Ph.D. degree in computer science from Northwestern Polytechnical University, Xi’an, China, in 2004. He is currently a Professor with School of Computer Science

Enhanced Photovoltage Response of Hematite-X-Ferrite Interfaces (X = Cr, Mn, Co, or Ni)

High-fluorescent p-X-ferrites (XFe2O4; XFO; X = Fe, Cr, Mn, Co, or Ni) embedded in n-hematite (Fe2O3) surfaces were successfully fabricated via a facile bio-approach using Shewanella oneidensis MR-1. The results revealed that the X ions with high/low work functions modify the unpaired spin Fe2+–O2− orbitals in the XFe2O4 lattices to become localized paired spin orbitals at the ...

Drug repurposing to target Ebola virus replication and virulence using structural systems pharmacology

Background The recent outbreak of Ebola has been cited as the largest in history. Despite this global health crisis, few drugs are available to efficiently treat Ebola infections. Drug repurposing provides a potentially efficient solution to accelerating the development of therapeutic approaches in response to Ebola outbreak. To identify such candidates, we use an integrated ...

Mechanism of Fluorescence Enhancement of Biosynthesized XFe2O4–BiFeO3 (X = Cr, Mn, Co, or Ni) Membranes

Ferrites–bismuth ferrite is an intriguing option for medical diagnostic imaging device due to its magnetoelectric and enhanced near-infrared fluorescent properties. However, the embedded XFO nanoparticles are randomly located on the BFO membranes, making implementation in devices difficult. To overcome this, we present a facile bio-approach to produce XFe2O4–BiFeO3 (XFO–BFO) (X = ...

Mechanism of Fluorescence Enhancement of Biosynthesized XFe2O4–BiFeO3 (X = Cr, Mn, Co, or Ni) Membranes

Ferrites–bismuth ferrite is an intriguing option for medical diagnostic imaging device due to its magnetoelectric and enhanced near-infrared fluorescent properties. However, the embedded XFO nanoparticles are randomly located on the BFO membranes, making implementation in devices difficult. To overcome this, we present a facile bio-approach to produce XFe2O4–BiFeO3 (XFO–BFO) (X = ...

Multimodal joint information processing in human machine interaction: recent advances

. We also thank to the reviewers for their excellent help in reviewing the manuscripts. Lei Xie received the Ph.D. degree in computer science from Northwestern Polytechnical University, Xian, China, in

Beilschmiedia turbinata: A Newly Recognized but Dying Species of Lauraceae from Tropical Asia Based on Morphological and Molecular Data

China took great efforts to reforestation, even turned the long-term forest loss into a net gain, but this cannot hide the loss of species diversity due to destruction of primary forests, habitat loss, invasion of alien species, and over exploitation. Here we provide such a case by recording a dying tree species of Lauraceae from the evergreen forests of SE Yunnan of China and ...

Quantifying Reproducibility in Computational Biology: The Case of the Tuberculosis Drugome

. Wrote the paper: DG YG PB. Designed and performed the TB-Drugome experiment: SK Li Xie Lei Xie PB. Tested the automated workflow and reported feedback: YZ. Contributed to the manuscript writting with ... feedback: SK Li Xie Lei Xie. 1. Bourne PE ( 2010 ) What Do I Want from the Publisher of the Future ? PLoS Comput Biol 6 ( 5 ) : e1000787 . doi:10.1371/journal.pcbi.1000787. 2. Gil Y , Deelman E , Ellisman M

Towards Structural Systems Pharmacology to Study Complex Diseases and Personalized Medicine

Genome-Wide Association Studies (GWAS), whole genome sequencing, and high-throughput omics techniques have generated vast amounts of genotypic and molecular phenotypic data. However, these data have not yet been fully explored to improve the effectiveness and efficiency of drug discovery, which continues along a one-drug-one-target-one-disease paradigm. As a partial consequence, ...

Antibacterial mechanisms identified through structural systems pharmacology

Background The growing discipline of structural systems pharmacology is applied prospectively in this study to predict pharmacological outcomes of antibacterial compounds in Escherichia coli K12. This work builds upon previously established methods for structural prediction of ligand binding pockets on protein molecules and utilizes and expands upon the previously developed genome ...

A Regulatory Feedback Loop between HIF-1α and PIM2 in HepG2 Cells

To survive under hypoxic conditions, cancer cells remodel glucose metabolism to support tumor progression. HIF transcription factor is essential for cellular response to hypoxia. The underlying mechanism how HIF is constitutively activated in cancer cells remains elusive. In the present study, we characterized a regulatory feedback loop between HIF-1α and PIM2 in HepG2 cells. ...

Drug Discovery Using Chemical Systems Biology: Weak Inhibition of Multiple Kinases May Contribute to the Anti-Cancer Effect of Nelfinavir

Nelfinavir is a potent HIV-protease inhibitor with pleiotropic effects in cancer cells. Experimental studies connect its anti-cancer effects to the suppression of the Akt signaling pathway, but the actual molecular targets remain unknown. Using a structural proteome-wide off-target pipeline, which integrates molecular dynamics simulation and MM/GBSA free energy calculations with ...

A unified statistical model to support local sequence order independent similarity searching for ligand-binding sites and its application to genome-based drug discovery

Functional relationships between proteins that do not share global structure similarity can be established by detecting their ligand-binding-site similarity. For a large-scale comparison, it is critical to accurately and efficiently assess the statistical significance of this similarity. Here, we report an efficient statistical model that supports local sequence order independent ...

SMAP-WS: a parallel web service for structural proteome-wide ligand-binding site comparison

The proteome-wide characterization and analysis of protein ligand-binding sites and their interactions with ligands can provide pivotal information in understanding the structure, function and evolution of proteins and for designing safe and efficient therapeutics. The SMAP web service (SMAP-WS) meets this need through parallel computations designed for 3D ligand-binding site ...