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Evaluating progestogens for prevention of preterm birth international collaborative (EPPPIC) individual participant data (IPD) meta-analysis: protocol

Preterm birth is the most common cause of death and harm to newborn babies. Babies that are born early may have difficulties at birth and experience health problems during early childhood. Despite extensive study, there is still uncertainty about the effectiveness of progestogen (medications that are similar to the natural hormone progesterone) in preventing or delaying preterm ...

Evaluating progestogens for prevention of preterm birth international collaborative (EPPPIC) individual participant data (IPD) meta-analysis: protocol

Preterm birth is the most common cause of death and harm to newborn babies. Babies that are born early may have difficulties at birth and experience health problems during early childhood. Despite extensive study, there is still uncertainty about the effectiveness of progestogen (medications that are similar to the natural hormone progesterone) in preventing or delaying preterm ...

Women’s views and experiences of two alternative consent pathways for participation in a preterm intrapartum trial: a qualitative study

The Cord Pilot Trial compared alternative policies for timing of cord clamping at very preterm birth at eight UK hospitals. In addition to standard written consent, an oral assent pathway was developed for use when birth was imminent. The aim of this study was to explore women’s views and experiences of two alternative consent pathways to participate in the Cord Pilot Trial. We ...

Gentamicin versus ceftriaxone for the treatment of gonorrhoea (G-TOG trial): study protocol for a randomised trial

Background Gonorrhoea is a common sexually transmitted infection which causes genital pain and discomfort; in women it can also lead to pelvic inflammatory disease and infertility, and in men to epididymo-orchitis. Current treatment is with ceftriaxone, but there is increasing evidence of antimicrobial resistance which is reducing its effectiveness against gonorrhoea. A small, but ...

The ethical issues regarding consent to clinical trials with pre-term or sick neonates: a systematic review (framework synthesis) of the analytical (theoretical/philosophical) research

Background Conducting clinical trials with pre-term or sick infants is important if care for this population is to be underpinned by sound evidence. Yet, approaching the parents of these infants at such a difficult time raises challenges to obtaining valid informed consent for such research. In this study, we asked, What light does the analytical literature cast on an ethically ...

Can site performance be predicted? Results of an evaluation of the performance of a site selection questionnaire in five multicentre trials

Lelia Duley 0 1 0 Selection Questionnaire can improve selection of sites in large multicentre trials 1 Nottingham Clinical Trials Unit, University of Nottingham , Nottingham , UK © 2015 Coleby et al

Evaluation of a site selection questionnaire for the recruitment of trial sites into multi-centre trials: experiences from the nottingham clinical trials unit

Diane Whitham 0 Lelia Duley 0 0 University of Nottingham , Nottingham , UK 2013 Whitham and Duley; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the

FourFold Asthma Study (FAST): a study protocol for a randomised controlled trial evaluating the clinical cost-effectiveness of temporarily quadrupling the dose of inhaled steroid to prevent asthma exacerbations

to prevent asthma exacerbations Andrew Skeggs 4 Tricia McKeever 2 Lelia Duley 4 Eleanor Mitchell 4 Lucy Bradshaw 4 Kevin Mortimer 1 Samantha Walker 8 Steve Parrott 7 Andrew Wilson 6 Ian Pavord 5 Chris ... ), Andrew Skeggs and Rebecca Haydock (chair), Lelia Duley, Tricia McKeever, Lucy Bradshaw and Eleanor Mitchell. Trial Steering Committee: Philip Ind (chair), Hilary Pinnock, Jacqui Cooper, Adel Mansur, Kim

Clinicians’ and womens’ experiences of two consent pathways in a trial of timing of clamping at very preterm birth: a qualitative study

Angela Pushpa-Rajah 0 Lelia Duley 0 0 Nottingham Clinical Trials Unit, University of Nottingham , Nottingham , UK 1 Centre for Maternal and Child Health Research, City University , London , UK © 2015

Cord pilot trial: update to randomised trial protocol

Background The Cord Pilot Trial aimed to assess the feasibility of conducting a large UK randomised trial to compare the effects of alternative polices for timing of cord clamping (immediate within 20 seconds or deferred after at least 2 minutes) for very preterm birth before 32 weeks gestation. Initial recruitment was from March 2013 to February 2014, phase 2 was from March 2014 ...

The effectiveness of gentamicin in the treatment of Neisseria gonorrhoeae: a systematic review

Background A high level of resistance in Neisseria gonorrhoeae has developed against penicillins, sulphonamides, tetracyclines and quinolones, and recent surveillance data have shown a gradual reduction in sensitivity to current first-line agents with an upward drift in the minimum inhibitory concentration of ceftriaxone. Laboratory sensitivity testing suggests that gentamicin, an ...

Randomised trials during a public health crisis, such as pandemic flu: a case study for a model of ‘off the shelf' ready-to-go trials

Duley 1 Wei-Shen Lim 0 0 Nottingham University Hospitals NHS Trust , Nottingham , UK 1 University of Nottingham , Nottingham , UK 2013 Whitham et al; licensee BioMed Central Ltd. This is an Open Access