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Search: authors:"Leon Ptaszek"

3 papers found.
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Quantitative in vivo mapping of myocardial mitochondrial membrane potential

analysis: Nathaniel M. Alpert, Nicolas Guehl. Funding acquisition: Georges El Fakhri. Investigation: Nathaniel M. Alpert, Leon Ptaszek, Matthieu Pelletier-Galarneau, Dustin Wooten, Chao Ma, Kazue Takahashi ... , Georges El Fakhri. Methodology: Nathaniel M. Alpert, Nicolas Guehl, Leon Ptaszek, Jeremy Ruskin, Moussa C. Mansour, Dustin Wooten, Chao Ma, Kazue Takahashi, Yun Zhou, Timothy M. Shoup, Marc D. Normandin

Pattern Specification and Immune Response Transcriptional Signatures of Pericardial and Subcutaneous Adipose Tissue

Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality in the United States. Recent studies suggest that pericardial adipose tissue (PCAT) secretes inflammatory factors that contribute to the development of CVD. To better characterize the role of PCAT in the pathogenesis of disease, we performed a large-scale unbiased analysis of the transcriptional ...

A dimer of the lymphoid protein RAG1 recognizes the recombination signal sequence and the complex stably incorporates the high mobility group protein HMG2

RAG1 and RAG2 are the two lymphoid-specific proteins required for the cleavage of DNA sequences known as the recombination signal sequences (RSSs) flanking V, D or J regions of the antigen-binding genes. Previous studies have shown that RAG1 alone is capable of binding to the RSS, whereas RAG2 only binds as a RAG1/RAG2 complex. We have expressed recombinant core RAG1 (amino acids ...