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Annexin A5 reduces early plaque formation in ApoE -/- mice

. Author Contributions Conceptualization: Robert StoÈhr, Armand Jaminon, Chris Reutelingsperger. Data curation: Robert StoÈhr, Rick van Gorp. Formal analysis: Robert StoÈhr, Leon Schurgers, Chris ... Reutelingsperger. Funding acquisition: Chris Reutelingsperger. Investigation: Robert StoÈhr, Rick van Gorp, Armand Jaminon. Methodology: Robert StoÈhr. Supervision: Leon Schurgers, Chris Reutelingsperger

Microparticle-Induced Coagulation Relates to Coronary Artery Atherosclerosis in Severe Aortic Valve Stenosis

Background Circulating microparticles (MPs) derived from endothelial cells and blood cells bear procoagulant activity and promote thrombin generation. Thrombin exerts proinflammatory effects mediating the progression of atherosclerosis. Aortic valve stenosis may represent an atherosclerosis-like process involving both the aortic valve and the vascular system. The aim of this...

Molecular Imaging of Cell Death in Tumors. Increasing Annexin A5 Size Reduces Contribution of Phosphatidylserine-Targeting Function to Tumor Uptake

Objective Annexin A5 is a phosphatidylserine binding protein that binds dying cells in vivo. Annexin A5 is a potential molecular imaging agent to determine efficacy of anti-cancer therapy in patients. Its rapid clearance from circulation limits tumor uptake and, hence, its sensitivity. The aim of this study is to determine if non-invasive imaging of cell death in tumors will...

Relationship between sclerostin and cardiovascular calcification in hemodialysis patients: a cross-sectional study

Background Sclerostin is a Wnt pathway antagonist regulating osteoblast activity and bone turnover. Here, we assessed the potential association of sclerostin with the development of coronary artery (CAC) and aortic valve calcifications (AVC) in haemodialysis (HD) patients. Methods We conducted a cross-sectional multi-slice computed tomography (MS-CT) scanning study in 67 chronic...

Vitamin K1 to slow vascular calcification in haemodialysis patients (VitaVasK trial): a rationale and study protocol

Background Patients on haemodialysis (HD) exhibit increased cardiovascular mortality associated with accelerated vascular calcification (VC). VC is influenced by inhibitors such as matrix Gla protein (MGP), a protein activated in the presence of vitamin K. HD patients exhibit marked vitamin K deficiency, and supplementation with vitamin K reduces inactive MGP levels in these...