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57 papers found.
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Polymorphisms at microRNA binding sites of Ara-C and anthracyclines-metabolic pathway genes are associated with outcome of acute myeloid leukemia patients

Gene polymorphisms at microRNA-binding sites (poly-miRTS) may affect gene transcription and expression through miRNA regulation, which is associated with cancer susceptibility, sensitivity to chemotherapy and prognosis. This study investigated the association between poly-miRTS of Ara-C/anthracycline metabolic pathways genes and the outcome of acute myeloid leukemia (AML) in...

Hyperhomocysteinemia Promotes Insulin Resistance and Adipose Tissue Inflammation in PCOS Mice Through Modulating M2 Macrophage Polarization via Estrogen Suppression

It has been shown that serum homocysteine (Hcy) levels are higher in women with polycystic ovary syndrome (PCOS). However, the specific role of hyperhomocysteinemia (HHcy) in the development of PCOS has never been reported. Adipose tissue inflammation is featured by the infiltration of macrophages, which plays a critical role in the pathogenesis of glucose and insulin intolerance...

Whole genome sequence of the Treponema pallidum subsp. pallidum strain Amoy: An Asian isolate highly similar to SS14

-Li Liu, Li-Rong Lin, Jian-Jun Niu, Tian-Ci Yang. Investigation: Li-Li Liu. Methodology: Qiang Zhao, Kun Gao, Hui-Lin Zhang, Li-Rong Lin. Project administration: Tian-Ci Yang. Resources: Xiao-Zhen

Acute myeloid leukemia following etoposide therapy for EBV-associated hemophagocytic lymphohistiocytosis: a case report and a brief review of the literature

Background Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening disorder characterized by prolonged fever, cytopenia, hepatosplenomegaly, rash, icterus, and other neurological symptoms. Successful treatment of HLH by etoposide has improved outcomes for children with HLH. However, the development of treatment-related acute myeloid leukemia (t-AML) after the usage...

Optimization of medium compositions to improve a novel glycoprotein production by Streptomyces kanasenisi ZX01

Streptomyces kanasenisi ZX01 was found to produce a novel glycoprotein GP-1 previously, which was secreted into medium and had significant activity against tobacco mosaic virus. However, the low production of GP-1 by strain ZX01 limited its further studies. In order to improve the yield of GP-1, a series of statistical experimental design methods were applied to optimize medium...

THE IMPACT OF ORGANIZATIONAL CHANGE ON JOB SATISFACTION, AND INTENTION TO QUIT: A MEDIATING ROLE OF PSYCHOLOGICAL CONTRACT VIOLATION

Naseer Akhtar Long Li Rong 0 0 Huazhong University of Science & Technology , Wuhan, PR CHINA Organizations today are not in a stable position. The introduction of new advanced technology, increased

THE IMPACT OF ORGANIZATIONAL CHANGE ON JOB SATISFACTION, AND INTENTION TO QUIT: A MEDIATING ROLE OF PSYCHOLOGICAL CONTRACT VIOLATION

Naseer Akhtar Long Li Rong 0 0 Huazhong University of Science & Technology , Wuhan, PR CHINA Organizations today are not in a stable position. The introduction of new advanced technology, increased

Joint training of DNNs by incorporating an explicit dereverberation structure for distant speech recognition

We explore joint training strategies of DNNs for simultaneous dereverberation and acoustic modeling to improve the performance of distant speech recognition. There are two key contributions. First, a new DNN structure incorporating both dereverberated and original reverberant features is shown to effectively improve recognition accuracy over the conventional one using only...

Evaluation of the major royal jelly proteins as an alternative to fetal bovine serum in culturing human cell lines

Science of Zhejiang University (No. KY201404) , China ORCID: Li-rong SHEN Royal jelly (RJ) is a well-known bioactive substance. It contains large amounts of major royal jelly proteins (MRJPs), which ... -qiang LAI (JM-USDA HNRCA at Tufts University, USA) for editing the manuscript. Compliance with ethics guidelines Di CHEN, Xiao-xuan XIN, Hao-cheng QIAN, Zhang-yin YU, and Li-rong SHEN declare that they

Effect of Pregnane X Receptor * 1B genetic polymorphisms on postoperative analgesia with fentanyl in Chinese patients undergoing gynecological surgery

Background The purpose of the study was to investigate the effects of the pregnane X receptor (PXR)*1B polymorphisms on CYP3A4 enzyme activity and postoperative fentanyl consumption in Chinese patients undergoing gynecological surgery. Methods A total of 287 females of Han ethnicity, aged 20 to 50 years old, ASA I or II, scheduled to abdominal total hysterectomy or myomectomy...

MicroRNA-495 downregulates FOXC1 expression to suppress cell growth and migration in endometrial cancer

MicroRNAs (miRNAs) are a class of noncoding RNAs and function as key regulators of gene expression at the post-transcriptional level. In this study, we found that miR-495 reduces cell growth, induces apoptosis and suppresses the migration of endometrial cancer by directly inhibiting FOXC1 expression. Further analysis revealed that FOXC1 promotes growth and migration and functions...

Local Coding Based Matching Kernel Method for Image Classification

This paper mainly focuses on how to effectively and efficiently measure visual similarity for local feature based representation. Among existing methods, metrics based on Bag of Visual Word (BoV) techniques are efficient and conceptually simple, at the expense of effectiveness. By contrast, kernel based metrics are more effective, but at the cost of greater computational...

A rapid life cycle assessment method based on green features in supporting conceptual design

A Rapid Life Cycle Assessment (RLCA) method based on Green features is proposed in order to solve the inherent limitations of conventional Life Cycle Assessment (LCA), such as long period, massive data requirement, which result in difficulties in supporting product conceptual design. Firstly, Green Feature is proposed in supporting the LCA in conceptual design, where a mapping...

Electroacupuncture Ameliorates Acute Renal Injury in Lipopolysaccharide-Stimulated Rabbits via Induction of HO-1 through the PI3K/Akt/Nrf2 Pathways

Electroacupuncture at select acupoints have been verified to protect against organ dysfunctions during endotoxic shock. And, heme oxygenase (HO)-1 as a phase II enzyme and antioxidant contributed to the protection of kidney in septic shock rats. The phosphatidylinositol 3-kinase (PI3K)-Akt pathway mediated the activation of NF-E2 related factor-2 (Nrf2), which was involved in HO...

Protein Disulfide Isomerase Interacts with Tau Protein and Inhibits Its Fibrillization

Background Tau protein is implicated in the pathogenesis of neurodegenerative disorders such as tauopathies including Alzheimer disease, and Tau fibrillization is thought to be related to neuronal toxicity. Physiological inhibitors of Tau fibrillization hold promise for developing new strategies for treatment of Alzheimer disease. Because protein disulfide isomerase (PDI) is both...