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Loss of TLR4 in mouse Müller cells inhibits both MyD88-dependent and –independent signaling

Contributions Conceptualization: Jena J. Steinle. Data curation: Li Liu. Formal analysis: Li Liu. Funding acquisition: Jena J. Steinle. Investigation: Li Liu. Project administration: Jena J. Steinle ... . Supervision: Jena J. Steinle. Writing ± original draft: Jena J. Steinle. Writing ± review & editing: Li Liu, Jena J. Steinle. 7 / 8 14. 1. Lin X , Fang D , Zhou H , Su SB . The expression of Toll-like

An approach to localization for ensemble-based data assimilation

Methodology: Bin Wang, Juanjuan Liu. Software: Li Liu, Shiming Xu, Wenyu Huang. Writing ± original draft: Bin Wang, Juanjuan Liu. Writing ± review & editing: Bin Wang, Juanjuan Liu. 22 / 23 1. Evensen G

Inner lips feature extraction based on CLNF with hybrid dynamic template for Cued Speech

In previous French Cued Speech (CS) studies, one of the widely used methods is painting blue color on the speaker’s lips to make lips feature extraction easier. In this paper, in order to get rid of this artifice, a novel automatic method to extract the inner lips contour of CS speakers is presented. This method is based on a recent facial contour extraction model developed in...

Microstructural evolution of 96.5Sn–3Ag–0.5Cu lead free solder reinforced with nickel-coated graphene reinforcements under large temperature gradient

In this study, 96.5Sn–3Ag–0.5Cu (SAC305) lead-free composite solder containing graphene nanosheets (GNS) decorated with Ni nanoparticles (Ni-GNS) was prepared using a powder metallurgy method. A lab-made set-up and a corresponding Cu/solder/Cu sample design for assessing thermo-migration (TM) was established. The feasibility of this setup for TM stressing using an infrared...

Negative interferences by calcium dobesilate in the detection of five serum analytes involving Trinder reaction-based assays

: Xiuzhi Guo, Li'an Hou, Yicong Yin, Fang Zhao, Liangyu Xia, Xinqi Cheng, Qian Liu, Li Liu, Ermu Xu. Methodology: Xiuzhi Guo, Jie Wu. Project administration: Xiuzhi Guo, Ling Qiu. Resources: Li'an Hou

Fingolimod suppresses neuronal autophagy through the mTOR/p70S6K pathway and alleviates ischemic brain damage in mice

). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Author Contributions Conceptualization: Jun-Li Liu. Data curation: Xiao ... Li, Ming-Huan Wang. Formal analysis: Chuan Qin. Funding acquisition: Dai-Shi Tian, Jun-Li Liu. Investigation: Chuan Qin, Wen-Hui Fan. Methodology: Ming-Huan Wang, Chuan Qin, Wen-Hui Fan. Project

Template-Free Synthesis of Sb2S3 Hollow Microspheres as Anode Materials for Lithium-Ion and Sodium-Ion Batteries

Hierarchical Sb2S3 hollow microspheres assembled by nanowires have been successfully synthesized by a simple and practical hydrothermal reaction. The possible formation process of this architecture was investigated by X-ray diffraction, focused-ion beam-scanning electron microscopy dual-beam system, and transmission electron microscopy. When used as the anode material for lithium...

Inhibition of HMGB1 protects the retina from ischemia-reperfusion, as well as reduces insulin resistance proteins

The role of inflammation in diabetic retinal amage is well accepted. While a number of cytokines and inflammatory mediators are responsible for these changes, upstream regulators are less well studied. Additionally, the role for these upstream mediators in retinal health is unclear. In this study, we hypothesized that inhibition of high mobility group box 1 (HMGB1) could restore...

Clinical laboratory verification of thyroglobulin concentrations in the presence of autoantibodies to thyroglobulin: comparison of EIA, radioimmunoassay and LC MS/MS measurements in an Urban Hospital

Objective Thyroglobulin (Tg) measurements assess recurrence in post-thyroidectomy thyroid cancer patients. Tg measurements by enzyme immunoassays (EIA) can be falsely elevated by interference from Tg autoantibodies (TgAb). Radioimmunoassay (RIA) is less susceptible to TgAb interference and has been the standard-of-care test for TgAb positive patients. Recently developed liquid...

Oil charging history and pathways of the Ordovician carbonate reservoir in the Tuoputai region, Tarim Basin, NW China

Geochemical analysis of 64 oils sampled from an Ordovician carbonate reservoir in the Tuoputai region was undertaken to study the composition of molecular markers. All the oils have similar geochemical characteristics and belong to a single oil family. They are presumed to derive from the same source kitchen and have similar oil charging history. A histogram of homogenization...

Fast alternating projection methods for constrained tomographic reconstruction

The alternating projection algorithms are easy to implement and effective for large-scale complex optimization problems, such as constrained reconstruction of X-ray computed tomography (CT). A typical method is to use projection onto convex sets (POCS) for data fidelity, nonnegative constraints combined with total variation (TV) minimization (so called TV-POCS) for sparse-view CT...

A decision support model for investment on P2P lending platform

[41] also can be considered for the further improvement. Author Contributions Conceptualization: Xiangxiang Zeng. Data curation: Li Liu, Jiangze Du. Formal analysis: Li Liu. Funding acquisition ... : Xiangxiang Zeng. Investigation: Xiangxiang Zeng, Li Liu, Jiangze Du. Project administration: Jiangze Du. Supervision: Xiangxiang Zeng, Xun Wang, Tao Li. Validation: Stephen Leung. Visualization: Xun Wang

Increased MMAB level in mitochondria as a novel biomarker of hepatotoxicity induced by Efavirenz

Ma, Yanling Feng, Dage Wu, Lin Yin. Project administration: Lijun Zhang. Resources: Yanling Feng, Li Liu. Software: Xiaofang Jia. Supervision: Lijun Zhang. Validation: Zhimi Tan. Writing

Missense mutation at CLDN8 associated with a high plasma interferon gamma-inducible protein 10 level in methadone-maintained patients with urine test positive for morphine

Ministry of Science and Technology. All study subjects and research nurses are also appreciated. Author Contributions Conceptualization: Chia-Lung Shih, Yun Wang, Yu-Li Liu. Data curation: Tung-Hsia Liu ... : Tung-Hsia Liu, Ren-Hua Chung, Chia-Lung Shih. Supervision: Ren-Hua Chung, Yu-Li Liu. Validation: Hsiao-Hui Tsou. Visualization: Tung-Hsia Liu, Hsiang-Wei Kuo. Writing ± original draft: Tung-Hsia Liu

Characterization and physical mapping of nuclear ribosomal RNA (rRNA) genes in the haploid gametophytes of Saccharina japonica (Phaeophyta)

Nuclear tandemly repeated ribosomal RNA genes (18S-5.8S-25S rDNA and 5S rDNA) have been proven to be excellent cytogenetic markers for karyotype analysis of various higher plants by using the fluorescence in situ hybridization (FISH) technique. To illustrate physical mapping of these rDNAs in brown seaweed, Saccharina japonica, chromosomes, an approximately 5400-bp transcription...

Facile Synthesis of Silver Nanowires with Different Aspect Ratios and Used as High-Performance Flexible Transparent Electrodes

Silver nanowires (Ag NWs) are the promising materials to fabricate flexible transparent electrodes, aiming to replace indium tin oxide (ITO) in the next generation of flexible electronics. Herein, a feasible polyvinylpyrrolidone (PVP)-mediated polyol synthesis of Ag NWs with different aspect ratios is demonstrated and high-quality Ag NWs transparent electrodes (NTEs) are...

An analysis of drug resistance among people living with HIV/AIDS in Shanghai, China

Background Understanding the mechanisms of drug resistance can facilitate better management of antiretroviral therapy, helping to prevent transmission and decrease the morbidity and mortality of people living with HIV/AIDS. However, there is little data about transmitted drug resistance and acquired drug resistance for HIV/AIDS patients in Shanghai. Methods A retrospective cohort...

The stem cell factor SALL4 is an essential transcriptional regulator in mixed lineage leukemia-rearranged leukemogenesis

The stem cell factor spalt-like transcription factor 4 (SALL4) plays important roles in normal hematopoiesis and also in leukemogenesis. We previously reported that SALL4 exerts its effect by recruiting important epigenetic factors such as DNA methyltransferases DNMT1 and lysine-specific demethylase 1 (LSD1/KDM1A). Both of these proteins are critically involved in mixed lineage...

Random X-chromosome inactivation dynamics in vivo by single-cell RNA sequencing

Background Random X-chromosome inactivation (rXCI) is important for the maintenance of normal somatic cell functions in female eutherian mammals. The dynamics of X-chromosome inactivation initiation has been widely studied by assessing embryonic stem cell differentiation in vitro. To investigate the phenomenon in vivo, we applied RNA sequencing to single cells from female embryos...