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Epac1 Restores Normal Insulin Signaling through a Reduction in Inflammatory Cytokines

We have previously reported that Epac1 reduced inflammatory cytokines, which is protective to the diabetic retina. We have also published that impaired insulin signaling occurs in the diabetic retina. A reduction in interleukin-1 beta (IL-1β) and tumor necrosis factor alpha (TNFα) by Epac1 could potentially restore normal insulin signal transduction. Confocal microscopy was...

Loss of TLR4 in mouse Müller cells inhibits both MyD88-dependent and –independent signaling

Contributions Conceptualization: Jena J. Steinle. Data curation: Li Liu. Formal analysis: Li Liu. Funding acquisition: Jena J. Steinle. Investigation: Li Liu. Project administration: Jena J. Steinle ... . Supervision: Jena J. Steinle. Writing ± original draft: Jena J. Steinle. Writing ± review & editing: Li Liu, Jena J. Steinle. 7 / 8 14. 1. Lin X , Fang D , Zhou H , Su SB . The expression of Toll-like

Inner lips feature extraction based on CLNF with hybrid dynamic template for Cued Speech

In previous French Cued Speech (CS) studies, one of the widely used methods is painting blue color on the speaker’s lips to make lips feature extraction easier. In this paper, in order to get rid of this artifice, a novel automatic method to extract the inner lips contour of CS speakers is presented. This method is based on a recent facial contour extraction model developed in...

An approach to localization for ensemble-based data assimilation

Methodology: Bin Wang, Juanjuan Liu. Software: Li Liu, Shiming Xu, Wenyu Huang. Writing ± original draft: Bin Wang, Juanjuan Liu. Writing ± review & editing: Bin Wang, Juanjuan Liu. 22 / 23 1. Evensen G

STK39 blockage by RNA interference inhibits the proliferation and induces the apoptosis of renal cell carcinoma

STK39 blockage by RNA interference inhibits the proliferation and induces the apoptosis of renal cell carcinoma Qi Zhao,* Yanjun Zhu,* Li Liu, Hang Wang, Shuai Jiang, Xiaoyi Hu, Jianming Guo

Effect of panel shape on hydrodynamic performances of vertical v-shaped double- slotted cambered otter-board

The effect of panel shape on hydrodynamic performances of a vertical v-shaped double-slotted cambered otter-board was investigated using engineering models in a wind tunnel. Three different shape panels (rhomboid, left trapezoid and isosceles trapezoid) were evaluated at a wind speed of 28 m/s. Parameters measured included: drag coefficient Cx, lift coefficient Cy, pitch moment...

Microstructural evolution of 96.5Sn–3Ag–0.5Cu lead free solder reinforced with nickel-coated graphene reinforcements under large temperature gradient

In this study, 96.5Sn–3Ag–0.5Cu (SAC305) lead-free composite solder containing graphene nanosheets (GNS) decorated with Ni nanoparticles (Ni-GNS) was prepared using a powder metallurgy method. A lab-made set-up and a corresponding Cu/solder/Cu sample design for assessing thermo-migration (TM) was established. The feasibility of this setup for TM stressing using an infrared...

Inhibition of HMGB1 protects the retina from ischemia-reperfusion, as well as reduces insulin resistance proteins

The role of inflammation in diabetic retinal amage is well accepted. While a number of cytokines and inflammatory mediators are responsible for these changes, upstream regulators are less well studied. Additionally, the role for these upstream mediators in retinal health is unclear. In this study, we hypothesized that inhibition of high mobility group box 1 (HMGB1) could restore...

Fingolimod suppresses neuronal autophagy through the mTOR/p70S6K pathway and alleviates ischemic brain damage in mice

). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Author Contributions Conceptualization: Jun-Li Liu. Data curation: Xiao ... Li, Ming-Huan Wang. Formal analysis: Chuan Qin. Funding acquisition: Dai-Shi Tian, Jun-Li Liu. Investigation: Chuan Qin, Wen-Hui Fan. Methodology: Ming-Huan Wang, Chuan Qin, Wen-Hui Fan. Project

Template-Free Synthesis of Sb2S3 Hollow Microspheres as Anode Materials for Lithium-Ion and Sodium-Ion Batteries

Hierarchical Sb2S3 hollow microspheres assembled by nanowires have been successfully synthesized by a simple and practical hydrothermal reaction. The possible formation process of this architecture was investigated by X-ray diffraction, focused-ion beam-scanning electron microscopy dual-beam system, and transmission electron microscopy. When used as the anode material for lithium...

Fast alternating projection methods for constrained tomographic reconstruction

The alternating projection algorithms are easy to implement and effective for large-scale complex optimization problems, such as constrained reconstruction of X-ray computed tomography (CT). A typical method is to use projection onto convex sets (POCS) for data fidelity, nonnegative constraints combined with total variation (TV) minimization (so called TV-POCS) for sparse-view CT...

Negative interferences by calcium dobesilate in the detection of five serum analytes involving Trinder reaction-based assays

: Xiuzhi Guo, Li'an Hou, Yicong Yin, Fang Zhao, Liangyu Xia, Xinqi Cheng, Qian Liu, Li Liu, Ermu Xu. Methodology: Xiuzhi Guo, Jie Wu. Project administration: Xiuzhi Guo, Ling Qiu. Resources: Li'an Hou

Clinical laboratory verification of thyroglobulin concentrations in the presence of autoantibodies to thyroglobulin: comparison of EIA, radioimmunoassay and LC MS/MS measurements in an Urban Hospital

Objective Thyroglobulin (Tg) measurements assess recurrence in post-thyroidectomy thyroid cancer patients. Tg measurements by enzyme immunoassays (EIA) can be falsely elevated by interference from Tg autoantibodies (TgAb). Radioimmunoassay (RIA) is less susceptible to TgAb interference and has been the standard-of-care test for TgAb positive patients. Recently developed liquid...

A decision support model for investment on P2P lending platform

[41] also can be considered for the further improvement. Author Contributions Conceptualization: Xiangxiang Zeng. Data curation: Li Liu, Jiangze Du. Formal analysis: Li Liu. Funding acquisition ... : Xiangxiang Zeng. Investigation: Xiangxiang Zeng, Li Liu, Jiangze Du. Project administration: Jiangze Du. Supervision: Xiangxiang Zeng, Xun Wang, Tao Li. Validation: Stephen Leung. Visualization: Xun Wang

Oil charging history and pathways of the Ordovician carbonate reservoir in the Tuoputai region, Tarim Basin, NW China

Geochemical analysis of 64 oils sampled from an Ordovician carbonate reservoir in the Tuoputai region was undertaken to study the composition of molecular markers. All the oils have similar geochemical characteristics and belong to a single oil family. They are presumed to derive from the same source kitchen and have similar oil charging history. A histogram of homogenization...

Increased MMAB level in mitochondria as a novel biomarker of hepatotoxicity induced by Efavirenz

Ma, Yanling Feng, Dage Wu, Lin Yin. Project administration: Lijun Zhang. Resources: Yanling Feng, Li Liu. Software: Xiaofang Jia. Supervision: Lijun Zhang. Validation: Zhimi Tan. Writing

An analysis of drug resistance among people living with HIV/AIDS in Shanghai, China

Background Understanding the mechanisms of drug resistance can facilitate better management of antiretroviral therapy, helping to prevent transmission and decrease the morbidity and mortality of people living with HIV/AIDS. However, there is little data about transmitted drug resistance and acquired drug resistance for HIV/AIDS patients in Shanghai. Methods A retrospective cohort...

Interobserver Agreement in the Diagnosis of Inflammatory Bowel Disease-Associated Neoplasia in China in Comparison to Subspecialized American Gastrointestinal Pathologists

12Department of Gastroenterology/Hepatology, Cleveland Clinic, Cleveland, OH, USA Correspondence should be addressed to Xiu-li Liu; ude.lfu@uililuix Received 9 September 2017; Revised 12 December 2017

Characterization and physical mapping of nuclear ribosomal RNA (rRNA) genes in the haploid gametophytes of Saccharina japonica (Phaeophyta)

Nuclear tandemly repeated ribosomal RNA genes (18S-5.8S-25S rDNA and 5S rDNA) have been proven to be excellent cytogenetic markers for karyotype analysis of various higher plants by using the fluorescence in situ hybridization (FISH) technique. To illustrate physical mapping of these rDNAs in brown seaweed, Saccharina japonica, chromosomes, an approximately 5400-bp transcription...