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Let-7a inhibits osteosarcoma cell growth and lung metastasis by targeting Aurora-B

Let-7a inhibits osteosarcoma cell growth and lung metastasis by targeting Aurora-B Jing-Jing Yu,1,* Wen-Sen Pi,2,* Yuan Cao,3 Ai-Fen Peng,4 Zhi-Yuan Cao,2 Jia-Ming Liu,2 Shan-Hu Huang,2 Zhi-Li Liu,2

Control of Complex Nonlinear Dynamic Rational Systems

, Shanghai Jiao Tong University, 800 Dongchuan Rd., Minhang, Shanghai 200240, China Correspondence should be addressed to Li Liu; nc.ude.btsu@iluil Received 11 April 2018; Accepted 6 May 2018; Published 14

Epac1 Restores Normal Insulin Signaling through a Reduction in Inflammatory Cytokines

We have previously reported that Epac1 reduced inflammatory cytokines, which is protective to the diabetic retina. We have also published that impaired insulin signaling occurs in the diabetic retina. A reduction in interleukin-1 beta (IL-1β) and tumor necrosis factor alpha (TNFα) by Epac1 could potentially restore normal insulin signal transduction. Confocal microscopy was...

Dual upconversion nanophotoswitch for security encoding

 Li (李梦晓)Huanjun Wang (王焕军)Pan Zeng (曾盼)Li Liu (刘力)He Zheng (郑赫)Wei Wu (吴伟) Articles First Online: 04 September 2018 Received: 12 June 2018 Accepted: 13 August 2018 1 Shares 7

Decreased expression of peroxisome proliferator-activated receptor alpha indicates unfavorable outcomes in hepatocellular carcinoma

Decreased expression of peroxisome proliferator-activated receptor alpha indicates unfavorable outcomes in hepatocellular carcinoma Yong-bo Xiao,1,2,* Shao-hang Cai,1,2,* Li-li Liu,1,2 Xia Yang,1,2

Loss of TLR4 in mouse Müller cells inhibits both MyD88-dependent and –independent signaling

Contributions Conceptualization: Jena J. Steinle. Data curation: Li Liu. Formal analysis: Li Liu. Funding acquisition: Jena J. Steinle. Investigation: Li Liu. Project administration: Jena J. Steinle ... . Supervision: Jena J. Steinle. Writing ± original draft: Jena J. Steinle. Writing ± review & editing: Li Liu, Jena J. Steinle. 7 / 8 14. 1. Lin X , Fang D , Zhou H , Su SB . The expression of Toll-like

A time-domain substructure synthesis for finite rotations of flexible mechanical systems

This paper presents a floating IBS method for dynamic prediction of structures with finite rotations. The conventional IBS (impulse-based substructuring) method is efficient and accurate in structural transient impact analysis. When facing about finite rotations, the conventional IBS method will generate unreasonable results due to the lack of consideration of geometric...

Inner lips feature extraction based on CLNF with hybrid dynamic template for Cued Speech

In previous French Cued Speech (CS) studies, one of the widely used methods is painting blue color on the speaker’s lips to make lips feature extraction easier. In this paper, in order to get rid of this artifice, a novel automatic method to extract the inner lips contour of CS speakers is presented. This method is based on a recent facial contour extraction model developed in...

Three New Heptelidic Acid Derivatives from the Culture of Mushroom Lentinellus ursinus

Three new heptelidic acid derivatives (1–3) including two new dimeric esters and two known heptelidic acid analogues (4 and 5) were isolated from the solid culture of mushroom Lentinellus ursinus. The structures of new compounds were confirmed by the analysis of NMR and HRESIMS spectroscopic data. The biosynthetic origin of compounds 1–5 was postulated. Compounds 1–5 exhibited no...

An approach to localization for ensemble-based data assimilation

Methodology: Bin Wang, Juanjuan Liu. Software: Li Liu, Shiming Xu, Wenyu Huang. Writing ± original draft: Bin Wang, Juanjuan Liu. Writing ± review & editing: Bin Wang, Juanjuan Liu. 22 / 23 1. Evensen G

STK39 blockage by RNA interference inhibits the proliferation and induces the apoptosis of renal cell carcinoma

STK39 blockage by RNA interference inhibits the proliferation and induces the apoptosis of renal cell carcinoma Qi Zhao,* Yanjun Zhu,* Li Liu, Hang Wang, Shuai Jiang, Xiaoyi Hu, Jianming Guo

Effect of panel shape on hydrodynamic performances of vertical v-shaped double- slotted cambered otter-board

The effect of panel shape on hydrodynamic performances of a vertical v-shaped double-slotted cambered otter-board was investigated using engineering models in a wind tunnel. Three different shape panels (rhomboid, left trapezoid and isosceles trapezoid) were evaluated at a wind speed of 28 m/s. Parameters measured included: drag coefficient Cx, lift coefficient Cy, pitch moment...

Moderating role of self-efficacy on the associations of social support with depressive and anxiety symptoms in Chinese patients with rheumatoid arthritis

Moderating role of self-efficacy on the associations of social support with depressive and anxiety symptoms in Chinese patients with rheumatoid arthritis Li Liu,1 Neili Xu,2 Lie Wang1 1Department of

Metformin add-on continuous subcutaneous insulin infusion on precise insulin doses in patients with type 2 diabetes

). Author information Author notes Feng-fei Li, Bing-li Liu, Guo-ping Yin, Reng-na Yan and Danfeng Zhang contributed equally to this work. AffiliationsDepartment of Endocrinology, Nanjing First Hospital ... , Nanjing Medical University, Nanjing, ChinaFeng-fei Li, Bing-li Liu, Guo-ping Yin, Reng-na Yan, Dan-feng Zhang, Jin-dan Wu, Xiao-fei Su & Jian-hua MaNational Heart Research Institute Singapore, National

Microstructural evolution of 96.5Sn–3Ag–0.5Cu lead free solder reinforced with nickel-coated graphene reinforcements under large temperature gradient

In this study, 96.5Sn–3Ag–0.5Cu (SAC305) lead-free composite solder containing graphene nanosheets (GNS) decorated with Ni nanoparticles (Ni-GNS) was prepared using a powder metallurgy method. A lab-made set-up and a corresponding Cu/solder/Cu sample design for assessing thermo-migration (TM) was established. The feasibility of this setup for TM stressing using an infrared...

Inhibition of HMGB1 protects the retina from ischemia-reperfusion, as well as reduces insulin resistance proteins

The role of inflammation in diabetic retinal amage is well accepted. While a number of cytokines and inflammatory mediators are responsible for these changes, upstream regulators are less well studied. Additionally, the role for these upstream mediators in retinal health is unclear. In this study, we hypothesized that inhibition of high mobility group box 1 (HMGB1) could restore...

Fingolimod suppresses neuronal autophagy through the mTOR/p70S6K pathway and alleviates ischemic brain damage in mice

). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Author Contributions Conceptualization: Jun-Li Liu. Data curation: Xiao ... Li, Ming-Huan Wang. Formal analysis: Chuan Qin. Funding acquisition: Dai-Shi Tian, Jun-Li Liu. Investigation: Chuan Qin, Wen-Hui Fan. Methodology: Ming-Huan Wang, Chuan Qin, Wen-Hui Fan. Project

A decision support model for investment on P2P lending platform

[41] also can be considered for the further improvement. Author Contributions Conceptualization: Xiangxiang Zeng. Data curation: Li Liu, Jiangze Du. Formal analysis: Li Liu. Funding acquisition ... : Xiangxiang Zeng. Investigation: Xiangxiang Zeng, Li Liu, Jiangze Du. Project administration: Jiangze Du. Supervision: Xiangxiang Zeng, Xun Wang, Tao Li. Validation: Stephen Leung. Visualization: Xun Wang

Fast alternating projection methods for constrained tomographic reconstruction

The alternating projection algorithms are easy to implement and effective for large-scale complex optimization problems, such as constrained reconstruction of X-ray computed tomography (CT). A typical method is to use projection onto convex sets (POCS) for data fidelity, nonnegative constraints combined with total variation (TV) minimization (so called TV-POCS) for sparse-view CT...