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Visual and noxious electrical stimulus-evoked membrane-potential responses in anterior cingulate cortical neurons

Anterior cingulate cortex (ACC) is known to participate in numerous brain functions, such as memory storage, emotion, attention, as well as perception of acute and chronic pain. ACC-dependent brain functions often rely on ACC processing of various forms of environmental information. To understand the neural basis of ACC functions, previous studies have investigated ACC responses...

Mesenchymal stromal cells ameliorate oxidative stress-induced islet endothelium apoptosis and functional impairment via Wnt4-β-catenin signaling

Background Islet dysfunction and destruction are the common cause for both type 1 and type 2 diabetes mellitus (T2DM). The islets of Langerhans are highly vascularized miniorgans, and preserving the structural integrity and full function of the microvascular endothelium is vital for protecting the islets from the infiltration of immune cells and secondary inflammatory attack...

Holographic Fermions in Anisotropic Einstein-Maxwell-Dilaton-Axion Theory

Copyright © 2015 Li-Qing Fang and Xiao-Mei Kuang. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in ... there is no conflict of interests regarding the publication of this paper. Acknowledgments The authors would like to thank Long Cheng, Xian-Hui Ge, and Jian-Pin Wu for their helpful discussions. Li-Qing

Fermionic phase transition induced by the effective impurity in holography

We investigate the holographic fermionic phase transition induced by the effective impurity in holography, which is introduced by massless scalar fields in EinsteinMaxwell-massless scalar gravity. We obtain a phase diagram in (α, T ) plane separating the Fermi liquid phase and the non-Fermi liquid phase.

Antisense Morpholino Oligonucleotides Reduce Neurofilament Synthesis and Inhibit Axon Regeneration in Lamprey Reticulospinal Neurons

The sea lamprey has been used as a model for the study of axonal regeneration after spinal cord injury. Previous studies have suggested that, unlike developing axons in mammal, the tips of regenerating axons in lamprey spinal cord are simple in shape, packed with neurofilaments (NFs), and contain very little F-actin. Thus it has been proposed that regeneration of axons in the...

Tool Wear Detection Using Lipschitz Exponent and Harmonic Wavelet

The paper researches a novel engineering application of Lipschitz exponent function and harmonic wavelet for detecting tool condition. Tool wear affects often the quality grade of products and is gradually formed during cutting process. Meanwhile, since cutting noise is very strong, we think tool wear belongs to detecting weak singularity signals in strong noise. It is difficult...

Leukemoid reaction in cervical cancer: a case report and review of the literature

Background The presentation of a leukemoid reaction in cervical cancers is rare. A leukemoid reaction is defined as leukocytosis associated with a cause outside the bone marrow, with the white blood cell count (WBC) exceeding 50*109/L. Two cervical cancers presenting with leukemoid reactions were previously reported. However, the cancers in these cases were mainly in the advanced...

Personalized evaluation based on quantitative proteomics for drug-treated patients with chronic kidney disease

The patient's response to drug treatment is usually systems-wide based on multi-spots through either direct or indirect targets. Thus, the evaluation of the treatment cannot rely on single targeted biomarker, especially for complex diseases such as chronic kidney disease. In the present study, we performed a systems-wide analysis using proteomic approach to quantify changes in...

Surgical Strategy for Hepatocellular Carcinoma Patients with Portal/Hepatic Vein Tumor Thrombosis

Background Portal/hepatic vein tumor thrombosis (PVTT/HVTT) in hepatocellular carcinoma (HCC) is a sign of advanced stage disease and is associated with poor prognosis. This study investigated the surgical outcomes of patients with HCC and PVTT/HVTT to determine the most appropriate surgical treatment strategy for these patients. Materials and Methods The study population...

Expression Profiles of Long Noncoding RNAs and Messenger RNAs in Mn-Exposed Hippocampal Neurons of Sprague–Dawley Rats Ascertained by Microarray: Implications for Mn-Induced Neurotoxicity

Manganese (Mn) is an essential trace element, while excessive expose may induce neurotoxicity. Recently, lncRNAs have been extensively studied and it has been confirmed that lncRNAs participate in neural functions and aberrantly expressed lncRNAs are involved in neurological diseases. However, the pathological effects of lncRNAs on Mn-induced neurotoxicity remain unclear. In this...

Complete Chloroplast Genome Sequence of Poisonous and Medicinal Plant Datura stramonium: Organizations and Implications for Genetic Engineering

Datura stramonium is a widely used poisonous plant with great medicinal and economic value. Its chloroplast (cp) genome is 155,871 bp in length with a typical quadripartite structure of the large (LSC, 86,302 bp) and small (SSC, 18,367 bp) single-copy regions, separated by a pair of inverted repeats (IRs, 25,601 bp). The genome contains 113 unique genes, including 80 protein...

Quantum secure direct communication against the collective noise with polarization-entangled Bell states

We propose a quantum secure direct communication protocol via a collective noise channel, exploiting polarization-entangled Bell states and the nondemolition parity analysis based on weak cross-Kerr nonlinearities. The participant Bob, who will receive the secret information, sends one of two photons in a polarization-entangled Bell state exploiting the transmission circuit...

Investigation on Molecular Mechanism of Fibroblast Regulation and the Treatment of Recurrent Oral Ulcer by Shuizhongcao Granule-Containing Serum

 Deng De-hou,1 Xia Liang,1 Li Qing-lin,1 Tao Feng,4 and Shen Min-he3 1Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, China 2Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China ... paper. Authors’ Contribution Zhang Bo, Ruan Shan-ming, Wang Bei, and Li Qing-lin contributed equally to the project and are considered co-first authors. Acknowledgments The authors wish to acknowledge The

Coral Reefs and People in a High-CO2 World: Where Can Science Make a Difference to People?

Reefs and People at Risk Increasing levels of carbon dioxide in the atmosphere put shallow, warm-water coral reef ecosystems, and the people who depend upon them at risk from two key global environmental stresses: 1) elevated sea surface temperature (that can cause coral bleaching and related mortality), and 2) ocean acidification. These global stressors: cannot be avoided by...

Identification of Non-HIV Immunogens That Bind to Germline b12 Predecessors and Prime for Elicitation of Cross-clade Neutralizing HIV-1 Antibodies

A fundamental challenge for developing an effective and safe HIV-1 vaccine is to identify vaccine immunogens that can initiate and maintain immune responses leading to elicitation of broadly neutralizing HIV-1 antibodies (bnAbs) through complex maturation pathways. We have previously found that HIV-1 envelope glycoproteins (Env) lack measurable binding to putative germline...

Size-Class Effect Contributes to Tree Species Assembly through Influencing Dispersal in Tropical Forests

We have investigated the processes of community assembly using size classes of trees. Specifically our work examined (1) whether point process models incorporating an effect of size-class produce more realistic summary outcomes than do models without this effect; (2) which of three selected models incorporating, respectively environmental effects, dispersal and the joint-effect...

Detection of Upper Airway Status and Respiratory Events by a Current Generation Positive Airway Pressure Device

To compare a positive airway pressure (PAP) device's detection of respiratory events and airway status during device-detected apneas with events scored on simultaneous polysomnography (PSG).

Endoscopic submucosal dissection of esophageal granular cell tumor

Background Esophageal granular cell tumor (GCT) is a rare benign tumor with malignant potential. With wide application of endoscopic techniques, the esophageal GCT discovery rate and treatment strategy has changed. This study was to preliminarily evaluate outcomes of endoscopic diagnosis and treatment for esophageal GCT. Methods Fourteen patients (eight men, six women; median age...

Protective efficacy of recombinant canine adenovirus type-2 expressing TgROP18 (CAV-2-ROP18) against acute and chronic Toxoplasma gondii infection in mice

Background The use of recombinant viral vectors expressing T. gondii antigens is a safe and efficient approach to induce immune responses against the parasite, as well as a valuable tool for vaccine development. We have previously prolonged the survival time of mice challenged with the RH strain of T. gondii by immunizing the mice with a eukaryotic vector expressing the protein...