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Comparative effectiveness and tolerance of immunosuppressive treatments for idiopathic membranous nephropathy: A network meta-analysis

, Vlado Perkovic, Daqing Hong. Data curation: Song Ren, Ying Wang, Li Xian, Tadashi Toyama, Daqing Hong. Formal analysis: Song Ren, Daqing Hong. Funding acquisition: Guisen Li. Investigation: Song Ren ... , Li Xian, Daqing Hong. Methodology: Guisen Li, Vlado Perkovic, Daqing Hong. Resources: Daqing Hong. Software: Song Ren, Daqing Hong. Visualization: Song Ren, Daqing Hong. Writing ± original draft

Analysis of Genetic Variation in CYP450 Genes for Clinical Implementation

Background Genetic determinants of drug response remain stable throughout life and offer great promise to patient-tailored drug therapy. The adoption of pharmacogenetic (PGx) testing in patient care requires accurate, cost effective and rapid genotyping with clear guidance on the use of the results. Hence, we evaluated a 32 SNPs panel for implementing PGx testing in clinical ...

Mensenchymal stem cells can delay radiation-induced crypt death: impact on intestinal CD44+ fragments

increase the radioresistance of the epithelium in vitro. Author contributions Li-Xian Wang provided technical assistance during the sorting of the CD44+ crypt cells. Prof. Jin Wang revised the manuscript

Generation of peanut mutants by fast neutron irradiation combined with in vitro culture

Induced mutations have played an important role in the development of new plant varieties. In this study, we investigated the effects of fast neutron irradiation on somatic embryogenesis combined with plant regeneration in embryonic leaflet culture to develop new peanut (Arachis hypogaea L.) germplasm for breeding. The dry seeds of the elite cultivar Luhua 11 were irradiated with ...

Behavior of axially loaded tubular X-joints using bolted connection: mechanical model and validation

X-joints are one of the fundamental joint configurations used in a wide range of transmission tubular structures. Experimental investigation of four tubular X-joints with bolted connection was conducted in this study, and it was found that the annular plate was the main yielding control member of such X-joints. Moreover, the portion outside the effective width of the chord member ...

A genome-wide association study of limb bone length using a Large White?�?Minzhu intercross population

Background In pig, limb bone length influences ham yield and body height to a great extent and has important economic implications for pig industry. In this study, an intercross population was constructed between the indigenous Chinese Minzhu pig breed and the western commercial Large White pig breed to examine the genetic basis for variation in limb bone length. The aim of this ...

A meta-analysis: neoadjuvant chemotherapy versus primary surgery in ovarian carcinoma FIGO stageIII and IV

Background The purpose of the current study is to analyze the existing data comparing neoadjuvant chemotherapy with primary debulking surgery (PDS) in patients with advanced ovarian carcinoma. Methods Patients with stage IIIC and IV ovarian cancer were identified from articles in Medline, PubMed, Cochrane Library, and EMBASE database (1989 to February 2013). Two authors ...

Rho GTPases and Regulation of Cell Migration and Polarization in Human Corneal Epithelial Cells

PurposeEpithelial cell migration is required for regeneration of tissues and can be defective in a number of ocular surface diseases. This study aimed to determine the expression pattern of Rho family small G-proteins in human corneal epithelial cells to test their requirement in directional cell migration. MethodsRho family small G-protein expression was assessed by reverse ...

Two Monoclonal Antibodies Recognising aa 634-668 and aa 1026-1055 of NogoA Enhance Axon Extension and Branching in Cultured Neurons

In a previous study, we generated two monoclonal antibodies (mAbs) in mice, aNogoA-N and aNogo-66 mAb, which were raised against recombinant N-terminal fragments of rat NogoA and Nogo-66, respectively. When compared with the commercial rabbit anti-rat NogoA polyclonal antibody (pAb), which can specifically recognise NogoA, the two mAbs were also specific for the NogoA antigen in ...

The combination of decoy receptor 3 and soluble triggering receptor expressed on myeloid cells-1 for the diagnosis of nosocomial bacterial meningitis

Background Early diagnosis and appropriate antibiotic treatment can significantly reduce mortality of nosocomial bacterial meningitis. However, it is a challenge for clinicians to make an accurate and rapid diagnosis of bacterial meningitis. This study aimed at determining whether combined biomarkers can provide a useful tool for the diagnosis of bacterial meningitis. Methods A ...

Tramadol and Propentofylline Coadministration Exerted Synergistic Effects on Rat Spinal Nerve Ligation-Induced Neuropathic Pain

Neuropathic pain is an intractable clinical problem. Drug treatments such as tramadol have been reported to effectively decrease neuropathic pain by inhibiting the activity of nociceptive neurons. It has also been reported that modulating glial activation could also prevent or reverse neuropathic pain via the administration of a glial modulator or inhibitor, such as ...

Neuroprotective Effects of Sevoflurane against Electromagnetic Pulse-Induced Brain Injury through Inhibition of Neuronal Oxidative Stress and Apoptosis

Zhang Jin Wang Li-Chun Han Li-Ya Li Guang-Li Wu Yan-Ning Hou Guo-Zhen Guo Qiang Wang Han-Fei Sang Li-Xian Xu Zhongcong Xie, Massachusetts General Hospital, United States of America Electromagnetic pulse

Recipient IL-6-572C/G genotype is associated with reduced incidence of acute rejection following liver transplantation

Objective Acute rejection resulting from alloimmune responses is a major risk factor affecting patient survival following liver transplantation. Since interleukin (IL)-6 can mediate acute rejection, the association between IL-6 gene single nucleotide polymorphisms (SNPs) and incidence of acute rejection in liver transplant recipients was investigated.

Structure-function relationship of antimicrobial peptide cathelicidin Pc-CATH1

Cathelicidin Pc-CATH1 is a cathelicidin-derived myeloid antimicrobial peptide identified from Phasianus colchicus with strong antimicrobial activity against most of bacteria and fungi tested, including the clinically isolated (IS) drug-resistant strains. Considering the uniform distribution of net positive charge in both C- and N-terminus sequence of cathelicidin Pc-CATH1 and most ...

Inhibition of spinal astrocytic c-Jun N-terminal kinase (JNK) activation correlates with the analgesic effects of ketamine in neuropathic pain

Background We have previously reported that inhibition of astrocytic activation contributes to the analgesic effects of intrathecal ketamine on spinal nerve ligation (SNL)-induced neuropathic pain. However, the underlying mechanisms are still unclear. c-Jun N-terminal kinase (JNK), a member of mitogen-activated protein kinase (MAPK) family, has been reported to be critical for ...

Effects of DAPT and Atoh1 Overexpression on Hair Cell Production and Hair Bundle Orientation in Cultured Organ of Corti from Neonatal Rats

Background In mammals, hair cells do not undergo spontaneous regeneration when they are damaged and result in permanent hearing loss. Previous studies in cultured Organ of Corti dissected from neonatal animals have shown that both DAPT (r-secretase inhibitor in the Notch signal pathway) treatment and Atoh1 overexpression can induce supernumerary hair cells. The effects of ...

Spinal Astrocytic Activation Is Involved in a Virally-Induced Rat Model of Neuropathic Pain

Li-Xian Xu 0 Ashok Chauhan, University of South Carolina School of Medicine, United States of America 0 1 Department of Anesthesiology, Tangdu Hospital, The Fourth Military Medical University , Xi'an