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Clinical value of ALU concentration and integrity index for the early diagnosis of ovarian cancer: A retrospective cohort trial

Conceptualization: Chungen Xing, Kai Li. Data curation: Rong Zhang, Wangyang PU, Shuyun Zhang, Li Chen, Weipei Zhu. Formal analysis: Rong Zhang, Wangyang PU, Shuyun Zhang, Li Chen, Weipei Zhu, Li Xiao, Funding ... acquisition: Rong Zhang, Chungen Xing. Investigation: Rong Zhang, Shuyun Zhang, Li Chen, Weipei Zhu. Methodology: Rong Zhang, Wangyang PU, Li Xiao, Kai Li. Resources: Shuyun Zhang, Li Chen, Weipei Zhu

The graduation performance of technology business incubators in China’s three tier cities: the role of incubator funding, technical support, and entrepreneurial mentoring

This study examines the effects of technology business incubator (TBI)’s funding, technical support and entrepreneurial mentoring on the graduation performance of new technology-based firms in China’s three tier cities. Using a new dataset on all TBIs and incubated new technology-based firms from government surveys conducted over five consecutive years from 2009 to 2013 combined...

Conditional removal of the canonical TGF-β1 signaling delays condylar cartilage degeneration induced by a partial discectomy in mice

Recent emerging data indicate that the increase in the expression and activity of the transforming growth factor beta 1 (Tgf-β1) signaling may have detrimental effect to mature articular cartilage of knee joints. However, there is no information about whether or not this is the case in condylar cartilages. The objective of this study is to investigate the protein expression and...

Analysis of the tonsillar microbiome in young adults with sore throat reveals a high relative abundance of Fusobacterium necrophorum with low diversity

, Arthur H. Totten, Carlos A. Estrada. Funding acquisition: T. Prescott Atkinson. Investigation: T. Prescott Atkinson, Michael B. Faircloth, Ken B. Waites. Methodology: Robert M. Centor, Li Xiao, Casey D ... . Morrow, Ken B. Waites. Software: Li Xiao, Casey D. Morrow. Supervision: T. Prescott Atkinson, Robert M. Centor, Li Xiao, Michael B. Faircloth, Ken B. Waites. Writing ± original draft: T. Prescott

Therapeutic target database update 2018: enriched resource for facilitating bench-to-clinic research of targeted therapeutics

Extensive efforts have been directed at the discovery, investigation and clinical monitoring of targeted therapeutics. These efforts may be facilitated by the convenient access of the genetic, proteomic, interactive and other aspects of the therapeutic targets. Here, we describe an update of the Therapeutic target database (TTD) previously featured in NAR. This update includes...

Antibacterial small molecules targeting the conserved TOPRIM domain of DNA gyrase

, Marc Labroli, Li Xiao, Giovanna Scapin, Nichole Buist, Christopher M. Tan, Todd A. Black, Terry Roemer. Zuck, Stacia Kargman, Li Xiao, Kristine Devito. Data curation: Ronald E. Painter, Brad Sherborne ... Wiltsie, Brad Sherborne, Xinwei Sher, Paul Mann, Paul Zuck, Li Xiao, Giovanna Scapin, Scott Salowe, KrisMethodology: Scott S. Walker, Marc Labroli, Paul Mann, Scott Salowe, Nichole Buist. Project

Prediction of cancer progression in a group of 73 gastric cancer patients by circulating cell-free DNA

Background Circulating cell-free DNA (ccf-DNA) in plasma may contain both specific and non-specific of tumor markers. The concentration and integrity of ccf-DNA may be clinical useful for detecting and predicting cancer progression. Methods Plasma samples from 40 healthy controls and 73 patients with gastric cancers (two stage 0, 17 stage I, 11 stage II, 33 stage III, and 10...

NLO QCD + NLO EW corrections to WZZ productions with leptonic decays at the LHC

Precision tests of the Standard Model (SM) require not only accurate experiments, but also precise and reliable theoretical predictions. Triple vector boson production provides a unique opportunity to investigate the quartic gauge couplings and check the validity of the gauge principle in the SM. Since the tree-level predictions alone are inadequate to meet this demand, the next...

Molecular characterization and multilocus genotypes of Enterocytozoon bieneusi among horses in southwestern China

Background Enterocytozoon bieneusi is one of the most prevalent causative species of diarrhea and enteric diseases in various hosts. E. bieneusi has been identified in humans, mammals, birds, rodents and reptiles in China, but few studies have reported E. bieneusi in horses. Therefore, the present study was conducted to assess the prevalence, molecular characteristics and...

INSTITUTIONAL TRANSITION AND THE FINANCING OF HIGH-TECH SMES IN CHINA: A LONGITUDINAL PERSPECTIVE

F RO N T I E R S O F E N T R E P R E N E U R S H I P R E S E A RC H Li Xiao 0 0 This Paper is brought to you for free and open access by the Entrepreneurship at Babson at Digital Knowledge at

Comment on Paolo et al. “Effect of pulsed electromagnetic field therapy in patients undergoing total knee arthroplasty: a randomized controlled trial”

Shengtan Zhang Li Xiao Li Chen Xinyu Lan Jishan Lan 0 ) Department of Anesthesiology, Cangzhou Hospital of Integrated Traditional and Western Medicine of Hebei Province , Cangzhou 061001, Hebei Prov

Comparative genome analysis of Mycoplasma pneumoniae

Background Mycoplasma pneumoniae is a common pathogen that causes upper and lower respiratory tract infections in people of all ages, responsible for up to 40 % of community-acquired pneumonias. It also causes a wide array of extrapulmonary infections and autoimmune phenomena. Phylogenetic studies of the organism have been generally restricted to specific genes or regions of the...

Increased plasma BMP-2 levels are associated with atherosclerosis burden and coronary calcification in type 2 diabetic patients

Background Although Bone morphogenetic protein-2 (BMP-2) is a known mediator of bone regeneration and vascular calcification, to date no study has investigated the relationship between BMP-2 and type 2 diabetes mellitus (T2DM) and its possible role in coronary artery disease (CAD). The purpose of this study is to evaluate the relationship of BMP-2 with atherosclerosis and...

Increased Cystic Fibrosis Transmembrane Conductance Regulators Expression and Decreased Epithelial Sodium Channel Alpha Subunits Expression in Early Abortion: Findings from a Mouse Model and Clinical Cases of Abortion

The status of the maternal endometrium is vital in regulating humoral homeostasis and for ensuring embryo implantation. Cystic fibrosis transmembrane conductance regulators (CFTR) and epithelial sodium channel alpha subunits (ENaC-α) play an important role in female reproduction by maintaining humoral and cell homeostasis. However, it is not clear whether the expression levels of...

Increased expression of the pluripotency markers sex-determining region Y-box 2 and Nanog homeobox in ovarian endometriosis

Background The precise etiology of endometriosis is not fully understood; the involvement of stem cells theory is a new hypothesis. Related studies mainly focus on stemness-related genes, and pluripotency markers may play a role in the etiology of endometriosis. We aimed to analyze the transcription pluripotency factors sex-determining region Y-box 2 (SOX2), Nanog homeobox (NANOG...

MiR-22/Sp-1 Links Estrogens With the Up-Regulation of Cystathionine γ-Lyase in Myocardium, Which Contributes to Estrogenic Cardioprotection Against Oxidative Stress

Hydrogen sulfide, generated in the myocardium predominantly via cystathionine-γ-lyase (CSE), is cardioprotective. Our previous study has shown that estrogens enhance CSE expression in myocardium of female rats. The present study aims to explore the mechanisms by which estrogens regulate CSE expression, in particular to clarify the role of estrogen receptor subtypes and the...