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167 papers found.
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The mutation of hepatitis B virus and the prognosis of hepatocellular carcinoma after surgery: a pilot study

The mutation of hepatitis B virus and the prognosis of hepatocellular carcinoma after surgery: a pilot study Yaojun Zhang,1,2,* Junting Huang,1,2,* Jinbin Chen,1,2 Keli Yang,1,2 Jiancong Chen,1,2 Li

Clinical utility of the revised cardiac risk index in older Chinese patients with known coronary artery disease

Clinical utility of the revised cardiac risk index in older Chinese patients with known coronary artery disease Lu Che, Li Xu, Yuguang Huang, Chunhua Yu Department of Anesthesiology, Peking Union

Adenocarcinoma of the lung with EGFR gene mutation and subsequent resistance mechanisms exploration: case report

Adenocarcinoma of the lung with EGFR gene mutation and subsequent resistance mechanisms exploration: case report Li Xu,1,2 Qian Z Wang,1,2 Lin Wu1,2 1Department of the Second Chest Medicine, Hunan

Function of the natalisin receptor in mating of the oriental fruit fly, Bactrocera dorsalis (Hendel) and testing of peptidomimetics

. Funding acquisition: Hong-Bo Jiang. Investigation: Shun-Hua Gui, Yu-Xia Pei, Li Xu, Wei-Ping Wang, Krzysztof Kaczmarek, Janusz Zabrocki. Methodology: Jin-Jun Wang. Supervision: Hong-Bo Jiang, Ronald J

Aptamer–drug conjugate: targeted delivery of doxorubicin in a HER3 aptamer-functionalized liposomal delivery system reduces cardiotoxicity

Aptamer-drug conjugate: targeted delivery of doxorubicin in a HER3 aptamer-functionalized liposomal delivery system reduces cardiotoxicity Xiao-qian Dou,1 Hua Wang,2 Jing Zhang,3 Fang Wang,3 Gui-li

Dependence of Initial Value on Pattern Formation for a Logistic Coupled Map Lattice

The logistic coupled map lattices (LCML) have been widely investigated as well as their pattern dynamics. The patterns formation may depend on not only fluctuations of system parameters, but variation of the initial conditions. However, the mathematical discussion is quite few for the effect of initial values so far. The present paper is concerned with the pattern formation for a...

Functional characterization of an aquaporin from a microsporidium, Nosema bombycis

Contributions Conceptualization: Gong Chen, Zhongyuan Shen. Data curation: Gong Chen, Zhongyuan Shen. Formal analysis: Zhongyuan Shen. Funding acquisition: Zhongyuan Shen. Investigation: Gong Chen, Li Xu ... , Zhongyuan Shen. Methodology: Gong Chen, Wei Wang, Zhongyuan Shen. Project administration: Gong Chen, Zhongyuan Shen. Resources: Wei Wang, Hongli Chen, Weijiang Dai, Xiaoliang Li, Xudong Tang, Li Xu

Aromatic amino acids in the cellulose binding domain of Penicillium crustosum endoglucanase EGL1 differentially contribute to the cellulose affinity of the enzyme

The cellulose binding domain (CBD) of cellulase binding to cellulosic materials is the initiation of a synergistic action on the enzymatic hydrolysis of the most abundant renewable biomass resources in nature. The binding of the CBD domain to cellulosic substrates generally relies on the interaction between the aromatic amino acids structurally located on the flat face of the CBD...

Spatial analysis of gender variation in the prevalence of hypertension among the middle-aged and elderly population in Zhejiang Province, China

Background Previous studies have shown that there may be gender disparities in the prevalence of hypertension; however, these studies do not address the spatial information contained in the sample which may limit the analytical results. Our study extends the existing Shared Component Model (SCM) and compares its utility with a logistic regression model to evaluate the...

SESN2 correlates with advantageous prognosis in hepatocellular carcinoma

Background SESN2 plays important roles in the regulation of cell survival, cell protection, and tumor suppression. However, the relationship between SESN2 expression and the clinicopathological attributes of hepatocellular carcinoma (HCC) is barely investigated. Methods One-step quantitative reverse transcription PCR, Western blotting analysis in 15 fresh HCC tissues, and...

Delivery of curcumin by directed self-assembled micelles enhances therapeutic treatment of non-small-cell lung cancer

Delivery of curcumin by directed self-assembled micelles enhances therapeutic treatment of non-small-cell lung cancer Wen-Ting Zhu,1,2,* Sheng-Yao Liu,3,* Lei Wu,1,2 Hua-Li Xu,4 Jun Wang,1,2 Guo-Xin ... ; angiogenesis - open access to scientific and medical research hua-li Xu 4 increased expression of Bax. Conclusion: The mPEG–PLA copolymer micelles can serve as an efficient carrier for CUR. The CUR/mPEG–PLA

Integrative analysis of transcriptomics and proteomics of skeletal muscles of the Chinese indigenous Shaziling pig compared with the Yorkshire breed

Background The Shaziling pig (Sus scrofa) is a well-known indigenous breed in China. One of its main advantages over European breeds is its high meat quality. However, little genetic information is available for the Shaziling pig. To screen for differentially expressed genes and proteins that might be responsible for the meat quality, the longissimus dorsi muscles from Shaziling...

A Single Pair of Serotonergic Neurons Counteracts Serotonergic Inhibition of Ethanol Attraction in Drosophila

Attraction to ethanol is common in both flies and humans, but the neuromodulatory mechanisms underlying this innate attraction are not well understood. Here, we dissect the function of the key regulator of serotonin signaling—the serotonin transporter–in innate olfactory attraction to ethanol in Drosophila melanogaster. We generated a mutated version of the serotonin transporter...

Predictive values of diffusion-weighted imaging and perfusion-weighted imaging in evaluating the efficacy of transcatheter arterial chemoembolization for hepatocellular carcinoma

Tian,1 Wei-Ping Zhang,2 Li Xu,1 Ping Jin1 1Department of Radiology, 2Department of Oncology, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, People’s

Transcriptome Analysis of Storage Roots and Fibrous Roots of the Traditional Medicinal Herb Callerya speciosa (Champ.) ScHot

Callerya speciosa (Champ.) ScHot is a woody perennial plant in Fabaceae, the roots of which are used medicinally. The storage roots of C. speciosa are derived from fibrous roots, but not all fibrous roots can develop into storage roots. To detect key genes involved in storage roots formation, we performed Illumina sequencing of the C. speciosa storage roots and fibrous roots. De...

A Novel Peptide from Soybean Protein Isolate Significantly Enhances Resistance of the Organism under Oxidative Stress

Recent studies have indicated that protein hydrolysates have broad biological effects. In the current study we describe a novel antioxidative peptide, FDPAL, from soybean protein isolate (SPI). The aim of this study was to purify and characterize an antioxidative peptide from SPI and determine its antioxidative mechanism. LC–MS/MS was used to isolate and identify the peptide from...

A novel eurythermic and thermostale lipase LipM from Pseudomonas moraviensis M9 and its application in the partial hydrolysis of algal oil

Xu 0 Houjin Zhang 0 Yunjun Yan 0 0 Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology , Wuhan

Inhibition of CaMKIV relieves streptozotocin-induced diabetic neuropathic pain through regulation of HMGB1

Background The pathogenesis of diabetic neuropathic pain is complicated and its underlying mechanisms remain unclear. Calmodulin-dependent protein kinases (CaMKs) IV (CaMKIV), one of CaMKs, regulates several transcription factors in pain mechanisms. High-mobility group box 1 (HMGB1) is a key mediator in diabetic neuropathic pain. This study aims to find the roles and mechanisms...