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Screening novel stress granule regulators from a natural compound library

.-J. Chen was supported by the Excellent Postdoctoral fellowship from the Tsinghua-Peking Joint Center for Life Sciences. Li-Dan Hu, Xiang-Jun Chen, Xiao-Yan Liao and Yong-Bin Yan declare no conflict ... experiments. LDH, XJC, and YBY analyzed the data. LDH and YBY wrote the paper. Li-Dan Hu, Xiang-Jun Chen, Xiao-Yan Liao, Yong-Bin Yan& OPEN ACCESS This article is distributed under the terms of the Creative

Cataract-causing mutation S228P promotes βB1-crystallin aggregation and degradation by separating two interacting loops in C-terminal domain

potentials. More importantly, the mutation separated two interacting β/γ-crystallin; cataract-causing mutation; hydrophobic core; protein aggregation; protein folding - Liang-Bo Qi and Li-Dan Hu have ... ; SDS-PAGE, SDS-polyacrylamide gel electrophoresis; SEC, sizeexclusion chromatography; WT, wild type. COMPLIANCE WITH ETHICS GUIDELINES Liang-Bo Qi, Li-Dan Hu, Huihui Liu, Hai-Yun Li, Xiao-Yao Leng and