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12 papers found.
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Effects of nitroglycerine on coronary flow velocity before and during adenosine provocation

Background Transthoracic echocardiography-assessed coronary flow velocity reserve (CFVR) evaluates coronary microvascular arterial function. Coronary flow velocity measurements at baseline and during hyperemia are used to calculate CFVR. Adenosine infusion induces hyperemia but it is not known if it causes a maximal response. We hypothesized that pre-treatment with nitroglycerine...

Effects of nitroglycerine on coronary flow velocity before and during adenosine provocation

Background Transthoracic echocardiography-assessed coronary flow velocity reserve (CFVR) evaluates coronary microvascular arterial function. Coronary flow velocity measurements at baseline and during hyperemia are used to calculate CFVR. Adenosine infusion induces hyperemia but it is not known if it causes a maximal response. We hypothesized that pre-treatment with nitroglycerine...

Determinants of coronary flow reserve in non-diabetic patients with chest pain without myocardial perfusion defects

Background Microvascular dysfunction could be responsible for chest pain in patients without myocardial perfusion defects. We evaluated microvascular function using ultrasound-assessed coronary flow reserve (CFR) in patients with chest pain and normal myocardial perfusion scintigram. Secondly, we investigated association between cardiovascular parameters and decreased CFR in a...

Cardiovascular magnetic resonance detects the progression of impaired myocardial perfusion reserve and increased left-ventricular mass in mice fed a high-fat diet

. Competing interests Li-Ming Gan, an author of this manuscript works for AstraZeneca and we disclose research support from AstraZeneca. The authors declare that they have no competing interest. Consent for

Insulin resistance, endothelial function, angiogenic factors and clinical outcome in non-diabetic patients with chest pain without myocardial perfusion defects

, Jan Oscarsson and LiMing Gan are employed by AstraZeneca R&D Gothenburg. AstraZeneca provided support in the form of biochemical analysis and salaries for authors RAM, JIB, KW, ER, PJG, RFD, JO and LMG

Impaired Coronary and Renal Vascular Function in Spontaneously Type 2 Diabetic Leptin-Deficient Mice

-authors Julia Grönros, Suvi E Heinonen , Tasso Miliotis, Karin Jennbacken, Alan Sabirsh, Anette Ericsson , Ann- Cathrine Jönsson-Rylander and Li-ming Gan are employed by AstraZeneca R&D Mölndal. First ... Sabirsh, Anette Ericsson, Ann-Cathrine Jönsson-Rylander and Li-Ming Gan are employed by AstraZeneca R&D Mölndal. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials

Association between renin and atherosclerotic burden in subjects with and without type 2 diabetes

Background Activation of the renin-angiotensin-aldosterone-system (RAAS) has been proposed to contribute to development of vascular complications in type 2 diabetes (T2D). The aim of the present study was to determine if plasma renin levels are associated with the severity of vascular changes in subjects with and without T2D. Methods Renin was analyzed by the Proximity Extension...

Characterization of VCAM-1-Binding Peptide-Functionalized Quantum Dots for Molecular Imaging of Inflamed Endothelium

publish, or preparation of the manuscript. Competing Interests: The affiliation of Li-Ming Gan is AstraZeneca. This does not alter the authors adherence to all the PLOS ONE policies on sharing data and

Adiponectin Receptor 2 Deficiency Results in Reduced Atherosclerosis in the Brachiocephalic Artery in Apolipoprotein E Deficient Mice

Adiponectin has been shown to have beneficial cardiovascular effects and to signal through the adiponectin receptors, AdipoR1 and AdipoR2. The original aim of this study was to investigate the effect of combined AdipoR1 and AdipoR2 deficiency (AdipoR1-/-AdipoR2-/-) on atherosclerosis. However, we made the interesting observation that AdipoR1-/-AdipoR2-/- leads to embryonic...

Muscle Sympathetic Nerve Activity Is Related to a Surrogate Marker of Endothelial Function in Healthy Individuals

Background Evidence from animal studies indicates the importance of an interaction between the sympathetic nervous system and the endothelium for cardiovascular regulation. However the interaction between these two systems remains largely unexplored in humans. The aim of this study was to investigate whether directly recorded sympathetic vasoconstrictor outflow is related to a...