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Patients receiving androgen deprivation therapy for prostate cancer have an increased risk of depressive disorder

Androgen deprivation therapy (ADT) results in testosterone suppression, a hypothesized mechanism linking ADT to depressive symptoms. This study investigated the relationship between ADT and the risk of subsequently being diagnosed with depressive disorder (DD) during a 3-year follow-up period. The patient sample for this population-based, retrospective cohort study was retrieved ...

Rheumatoid Arthritis Was Negatively Associated with Alzheimer’s Disease: A Population-Based Case-Control Study

Some of the prior literature investigated the potential association between rheumatoid arthritis (RA) and Alzheimer's disease (AD) because these two diseases may share similar inflammatory mechanisms. Nevertheless, to date, findings of the previous literature are still controversial, and some methodological limitations were observed in those studies. The aim of this case-control ...

Increased risk for urological cancer associated with anxiety disorder: a retrospective cohort study

Background Anxiety disorders (ADs) are common with a high rate of medical comorbidities. Although the association between ADs and the overall cancer risk remains controversial, patients with ADs were found to be more likely to develop specific cancer types. Herein, we estimated the risk of developing urological cancers among patients with ADs in a 5-year follow-up period using a ...

Nephrectomy Type Was Not Associated with a Subsequent Risk of Coronary Heart Disease: A Population-Based Study

-Chien Huang 1 Li-Ting Kao 1 0 Division of Urology, Department of Surgery, Far Eastern Memorial Hospital , Banciao, Taiwan, 2 Graduate Program in Biomedical Informatics , College of Informatics, Yuan-Ze

Healthcare Service Utilization by Patients with Obstructive Sleep Apnea: A Population-Based Study

Objective Although obstructive sleep apnea (OSA) is not a life-threatening disease, very few studies have compared differences in healthcare service utilization between patients with and those without OSA in an Asian population according to different age groups. This study attempted to investigate differences in healthcare service utilization between patients with and those without ...

Comparison of clinical outcome between laparoscopic and open right hemicolectomy: a nationwide study

Background This study aimed to compare clinical outcome between laparoscopic and open right hemicolectomy. Methods The data were sourced from Taiwan’s National Health Insurance Research Database. This study included 14,320 and 1313 patients who underwent open and laparoscopic right hemicolectomies, respectively. The study outcome included “intensive care unit (ICU) admission,” ...

A Population-Based Study on the Association between Benign Prostatic Enlargement and Rheumatoid Arthritis

Benign prostatic hyperplasia is one of the chronic inflammatory conditions in ageing male populations. Rheumatoid arthritis (RA) is a major autoimmune disease and is also regarded as a chronic inflammatory disorder. Although RA and benign prostatic enlargement (BPE) may share the same underlying etiologies, almost no study has ever attempted to explore the relationship between RA ...

Psoriasis and the Risk of Pneumonia: A Population-Based Study

Background Psoriasis is a prevalent autoimmune disorder. Various studies have reported on the relationship between psoriasis and chronic diseases but very few have explored the association between psoriasis and subsequent acute infection. This retrospective cohort study aimed to compare the risk of pneumonia between subjects with and those without psoriasis. Methods The medical ...

An Appendectomy Increases the Risk of Rheumatoid Arthritis: A Five-Year Follow-Up Study

Many studies have reported a possible association of an appendectomy with rheumatoid arthritis (RA). However, findings of the relationship between an appendectomy and RA remain inconsistent. Furthermore, all such studies were conducted in Western societies, and relevant studies on the relationship between an appendectomy and RA in Asian countries are still lacking. In this study, ...

Association between Neovascular Age-Related Macular Degeneration and Dementia: A Population-Based Case-Control Study in Taiwan

Background Most available studies focusing on the association between neovascular age-related macular degeneration (AMD) and dementia have conflicting results. This study aimed to investigate the association between previously diagnosed AMD and dementia using a population-based dataset in Taiwan. Methods Data for this case-control study were retrospectively collected from the ...

Poor Clinical Outcomes among Pneumonia Patients with Depressive Disorder

Background Some studies suggested that psychological stress may be associated with the severity and duration of infectious diseases. In this population-based study, we investigated associations between depressive disorder (DD) and pneumonia outcomes in Taiwan with a large-scale database from the National Health Insurance. Methods Our study defined 112,198 patients who were ...

Weekly and Holiday-Related Patterns of Panic Attacks in Panic Disorder: A Population-Based Study

Background While chronobiological studies have reported seasonal variation in panic attacks (PA) episodes, information on the timing of PA by week-days may enable better understanding of the triggers of PA episodes and thereby provide pointers for suitable interventional approaches to minimize PA attacks. This study investigated weekly variation in potential PA admissions including ...

MDA5 Plays a Crucial Role in Enterovirus 71 RNA-Mediated IRF3 Activation

Induction of type-I interferons (IFNs), IFN-α/β, is crucial to innate immunity against RNA virus infection. Cytoplasmic retinoic acid-inducible gene I (RIG-I)-like receptors, including RIG-I and melanoma differentiation-associated gene 5 (MDA5), are critical pathogen sensors for activation of type-I IFN expression in response to RNA virus infection. MDA5 is required for type-I IFN ...