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Comparable efficacy and less toxicity of pegylated liposomal doxorubicin versus epirubicin for neoadjuvant chemotherapy of breast cancer: a case-control study

Comparable efficacy and less toxicity of pegylated liposomal doxorubicin versus epirubicin for neoadjuvant chemotherapy of breast cancer: a case-control study Minjun Dong,1 Liang Luo,2 Xiaogang Ying ... 3 Department of Pathology, sir run run shaw hospital, Zhejiang University school of Medicine , hangzhou, People's republic of china PowerdbyTCPDF(ww.tcpdf.org) liang luo 2 Xianqiu lu 3 Jianguo shen 1

Short-term Internet search using makes people rely on search engines when facing unknown issues

The Internet search engines, which have powerful search/sort functions and ease of use features, have become an indispensable tool for many individuals. The current study is to test whether the short-term Internet search training can make people more dependent on it. Thirty-one subjects out of forty subjects completed the search training study which included a pre-test, a six-day...

Homologs of SCAR/WAVE complex components are required for epidermal cell morphogenesis in rice

Filamentous actins (F-actins) play a vital role in epidermal cell morphogenesis. However, a limited number of studies have examined actin-dependent leaf epidermal cell morphogenesis events in rice. In this study, two recessive mutants were isolated: less pronounced lobe epidermal cell2-1 (lpl2-1) and lpl3-1, whose leaf and stem epidermis developed a smooth surface, with fewer...

An experimental and numerical study of micro deep drawing of SUS304 circular cups

Micro deep drawing is a promising technology for mass production of complex 3D micro metal products. Significant size effects at a micro scale, however, obstruct application of this technology and block utilisation of traditional finite element method (FEM). Therefore, a micro tensile test system was developed to obtain accurate material properties considering size effects...

How Much Do Metamemory Beliefs Contribute to the Font-Size Effect in Judgments of Learning?

Evidence shows that the font size of study items significantly influences judgments of learning (JOLs) and that people’s JOLs are generally higher for larger words than for smaller words. Previous studies have suggested that font size influences JOLs in a belief-based way. However, few studies have directly examined how much people’s beliefs contribute to the font-size effect in...

Experimental and numerical study of micro deep drawing

Micro forming is a key technology for an industrial miniaturisation trend, and micro deep drawing (MDD) is a typical micro forming method. It has great advantages comparing to other micro manufacturing methods, such as net forming ability, mass production potential, high product quality and complex 3D metal products fabrication capacity. Meanwhile, it is facing difficulties, for...

The Plasma Mitochondrial DNA Is an Independent Predictor for Post-Traumatic Systemic Inflammatory Response Syndrome

Background and PurposeMitochondrial DNA (mtDNA), a newly identified damage-associated molecular pattern, has been observed in trauma patients, however, little is known concerning the relationship between plasma mtDNA levels and concrete post-traumatic complications, particularly systemic inflammatory response syndrome (SIRS). The aim of this study is to determine whether plasma...

The Systematic Classification of Gallbladder Stones

Background To develop a method for systematic classification of gallbladder stones, analyze the clinical characteristics of each type of stone and provide a theoretical basis for the study of the formation mechanism of different types of gallbladder stones. Methodology A total of 807 consecutive patients with gallbladder stones were enrolled and their gallstones were studied. The...

The Prognostic Value of p16 Hypermethylation in Cancer: A Meta-Analysis

Background The prognostic value of p16 promoter hypermethylation in cancers has been evaluated for several years while the results remain controversial. We thus performed a systematic review and meta-analysis of studies assessing the impact of p16 methylation on overall survival (OS) and disease-free survival (DFS) to clarify this issue. Methods We searched Pubmed, Embase and ISI...

Cholecystolithiasis Is Associated with Clonorchis sinensis Infection

Background The objective of this study was to analyze gallbladder stones for direct evidence of a relationship between Clonorchis sinensis infection and gallbladder stones formation. Methodology We investigated one hundred eighty-three gallbladder stones for the presence of Clonorchis sinensis eggs using microscopy, and analyzed their composition using Fourier transform infrared...

JMJD2A contributes to breast cancer progression through transcriptional repression of the tumor suppressor ARHI

Introduction Breast cancer is a worldwide health problem and the leading cause of cancer death among females. We previously identified Jumonji domain containing 2A (JMJD2A) as a critical mediator of breast cancer proliferation, migration and invasion. We now report that JMJD2A could promote breast cancer progression through transcriptional repression of the tumor suppressor...

Tiny cystine stones in the gallbladder of a patient with cholecystolithiasis complicating acute cholecystitis: a case report

, bachelor’s degree, surgeon; Xing-qiang Wang, bachelor’s degree, surgeon; Pei-ming Zheng, master’s degree, researcher; Zhen-liang Luo, doctor’s degree, researcher. 1. Kratzer W , Mason RA , Kachele V

Effects of RNA interference-mediated gene silencing of JMJD2A on human breast cancer cell line MDA-MB-231 in vitro

Previous data demonstrate that JMJD2A is a cancer-associated gene and may be involved in human breast cancer by demethylation of H3K9me3. The aim of this study was to investigate depressive effects on JMJD2A by transfection with JMJD2A-sepcific siRNA in human breast cancer cell line MDA-MB-231 and effects on cell proliferation, invasion and migration. JMJD2A-specific siRNA was...

RhG-CSF Improves Radiation-induced Myelosuppression and Survival in the Canine Exposed to Fission Neutron Irradiation

Zu-Yin YU Ming LI A-Ru-Na HAN Shuang XING Hong-Ling OU Guo-Lin XIONG Ling XIE Yan-Fang ZHAO He XIAO Ya-Jun SHAN Zhen-Hu ZHAO Xiao-Lan LIU Yu-Wen CONG Qing-Liang LUO Neutron irradiation/rhG-CSF