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Long non-coding RNA tagging and expression manipulation via CRISPR/Cas9-mediated targeted insertion

the future. FOOTNOTES We thank Yuefang Zhang and Shifang Shan for their help in experiments. We also thank members of the entire Qiu lab for their help and suggestions. Tian-Lin Cheng is supported by ... The Knowledge Innovation Program of CAS 2014KIP205, Shanghai Sailing Program 15YF1414200, and NSFC #31600826. Zilong Qiu is supported by NSFC #91432111, #31625013. Tian-Lin Cheng and Zilong Qiu

A comprehensive overview of exosomes in ovarian cancer: emerging biomarkers and therapeutic strategies

Exosomes are nanoparticles(40-100 nm) secreted by most cells in the body, which can be isolated from several types of extracellular fluids. It has been shown that exosomes play a key role in intercellular communication and in transportation of genetic information. Emerging evidence shows that exosomes are mediators of metastasis in tumour cells, stromal cells and the extracellular ...

A comprehensive overview of exosomes in ovarian cancer: emerging biomarkers and therapeutic strategies

Exosomes are nanoparticles(40-100 nm) secreted by most cells in the body, which can be isolated from several types of extracellular fluids. It has been shown that exosomes play a key role in intercellular communication and in transportation of genetic information. Emerging evidence shows that exosomes are mediators of metastasis in tumour cells, stromal cells and the extracellular ...

A comprehensive overview of exosomes in ovarian cancer: emerging biomarkers and therapeutic strategies

Exosomes are nanoparticles(40-100 nm) secreted by most cells in the body, which can be isolated from several types of extracellular fluids. It has been shown that exosomes play a key role in intercellular communication and in transportation of genetic information. Emerging evidence shows that exosomes are mediators of metastasis in tumour cells, stromal cells and the extracellular ...

Ezh2 does not mediate retinal ganglion cell homeostasis or their susceptibility to injury

and Jonatan Olafsson for help with RGC counts. Author Contributions Conceptualization: Dong Feng Chen. Data curation: Lin Cheng, Lucy J. Wong, Naihong Yan, Richard C. Han, Honghua Yu, Chenying Guo ... , Khulan Batsuuri, Aniket Zinzuwadia, Ryan Guan, Kin-Sang Cho. Formal analysis: Lin Cheng, Lucy J. Wong, Naihong Yan, Richard C. Han, Khulan Batsuuri, Aniket Zinzuwadia, Ryan Guan, Kin-Sang Cho, Dong Feng

Cocktail of chemical compounds robustly promoting cell reprogramming protects liver against acute injury

epithelial; TGF-β, transforming growth factor beta; VPA, valproic acid. COMPLIANCE WITH ETHICS GUIDELINES Lin Cheng and Yuewen Tang declare that they have no conflict of interest. All institutional and

Evaluating turnaround times for early infant diagnosis samples in Kenya from 2011-2014: A retrospective analysis of HITSystem program data

Wexler, An-Lin Cheng, Brad Gautney, Sarah Finocchario-Kessler, Kathy Goggin, Samoel Khamadi. Project administration: Catherine Wexler, Brad Gautney, Sarah Finocchario-Kessler, . Supervision: Brad Gautney ... , Sarah Finocchario-Kessler, Kathy Goggin, Samoel Khamadi, . Visualization: An-Lin Cheng. Writing ± original draft: Catherine Wexler. Writing ± review & editing: Catherine Wexler, An-Lin Cheng, Brad

Interleukin-35 on B cell and T cell induction and regulation

Interleukin (IL)-35 is a relatively newly discovered member of IL-12 cytokine family that is unique in that it is a dimer formed by two subunits. The review documents the structure, secretion and signal transduction of IL-35, the regulation effect of IL-35 on B cells and T cells as well as the adoptive transfer of IL-35+ regulatory B cells (Breg), therapeutic prospects of ...

Comparison of sentinel lymph node biopsy guided by indocyanine green, blue dye, and their combination in breast cancer patients: a prospective cohort study

study Jiajia Guo 0 Houpu Yang 0 Shu Wang Yingming Cao Miao Liu Fei Xie Peng Liu Bo Zhou Fuzhong Tong Lin Cheng Hongjun Liu Siyuan Wang 0 Equal contributors Peking University People's Hospital Breast

Production of high stellar-mass primordial black holes in trapped inflation

Trapped inflation has been proposed to provide a successful inflation with a steep potential. We discuss the formation of primordial black holes in the trapped inflationary scenario. We show that primordial black holes are naturally produced during inflation with a steep trapping potential. In particular, we have given a recipe for an inflaton potential with which particle ...

Qualitative insights into the experiences of living with moderate-to-severe lower urinary tract symptoms among community-dwelling ageing males

Ping Suen, Hui Lin Cheng, Simon Kai Wang Yeung, Cypher Ho Au-Yeung, Jillianne Chi Yen Lee, Kathy Kit Ying Ho, Natalie Ming Yan Lau, Cristina Ka Fu Ng, Iris Wai Sze Chan. Formal analysis: Lorna Kwai Ping ... Suen, Hui Lin Cheng, Simon Kai Wang Yeung, Cypher Ho Au-Yeung, Jillianne Chi Yen Lee, Kathy Kit Ying Ho, Natalie Ming Yan Lau, Cristina Ka Fu Ng, Iris Wai Sze Chan. Funding acquisition: Lorna Kwai Ping

Functional genetic variant of WW domain-containing oxidoreductase (WWOX) gene is associated with hepatocellular carcinoma risk

Background Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide. Human WW domain-containing oxidoreductase (WWOX) gene has been identified as a tumor suppressor gene in multiple cancers. We hypothesize that genetic variations in WWOX are associated with HCC risk. Methodology/Principal findings Five single-nucleotide polymorphisms (SNPs) of the WWOX ...

MAGIC Study: Aims, Design and Methods using SystemCHANGE™ to Improve Immunosuppressive Medication Adherence in Adult Kidney Transplant Recipients

Shirley Moore 3 Donna Hathaway 1 An-Lin Cheng 0 Guoqing Chen 5 Kathy Goggin 4 0 School of Nursing and Health Studies, University of Missouri-Kansas City , Health Sciences Building 2407, Kansas City, MO

Beta-Catenin Haplo Insufficient Male Mice Do Not Lose Bone in Response to Hindlimb Unloading

As the β-catenin pathway has been shown to be involved in mechanotransduction, we sought to determine if haploinsufficiency would affect skeletal response to unloading. It has previously been shown that deletion of both alleles of β-catenin in bone cells results in a fragile skeleton highly susceptible to fracture, but deletion of one allele using Dmp1-Cre (Ctnnb1+/loxP; Dmp1-Cre, ...

Cellular and Physiological Effects of Dietary Supplementation with β-Hydroxy-β-Methylbutyrate (HMB) and β-Alanine in Late Middle-Aged Mice

There is growing evidence that severe decline of skeletal muscle mass and function with age may be mitigated by exercise and dietary supplementation with protein and amino acid ingredient technologies. The purposes of this study were to examine the effects of the leucine catabolite, beta-hydroxy-beta-methylbutyrate (HMB), in C2C12 myoblasts and myotubes, and to investigate the ...

The Effects and Mechanism of Atorvastatin on Pulmonary Hypertension Due to Left Heart Disease

Background Pulmonary hypertension due to left heart disease (PH-LHD) is one of the most common forms of PH, termed group 2 PH. Atorvastatin exerts beneficial effects on the structural remodeling of the lung in ischemic heart failure. However, few studies have investigated the effects of atorvastatin on PH due to left heart failure induced by overload. Methods Group 2 PH was induced ...

Operational reliability evaluation of restructured power systems with wind power penetration utilizing reliability network equivalent and time-sequential simulation approaches

assessment. Lin CHENG was born in 1973. He received the B.S. degree in electrical engineering from Tianjin University, Tianjin, China, in 1996, and the Ph.D. degree in electrical engineering from Tsinghua

Predictors of Infant Age at Enrollment in Early Infant Diagnosis Services in Kenya

Despite the importance of early detection to signal lifesaving treatment initiation for HIV+ infants, early infant diagnosis (EID) services have received considerably less attention than other aspects of prevention of mother to child transmission care. This study draws on baseline data from an on-going cluster randomized study of an intervention to improve EID services at six ...