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Predictors of Infant Age at Enrollment in Early Infant Diagnosis Services in Kenya

Despite the importance of early detection to signal lifesaving treatment initiation for HIV+ infants, early infant diagnosis (EID) services have received considerably less attention than other aspects of prevention of mother to child transmission care. This study draws on baseline data from an on-going cluster randomized study of an intervention to improve EID services at six...

Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Improves Survival of Patients with Peritoneal Carcinomatosis from Gastric Cancer: Final Results of a Phase III Randomized Clinical Trial

Background This randomized phase III study was to evaluate the efficacy and safety of cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) for the treatment of peritoneal carcinomatosis (PC) from gastric cancer. Methods Sixty-eight gastric PC patients were randomized into CRS alone (n = 34) or CRS + HIPEC (n = 34) receiving cisplatin 120 mg and...

Intramuscular electroporation with the pro-opiomelanocortin gene in rat adjuvant arthritis

alpha and opioids in the disease . J Neuroimmunol 1994 , 51 : 169 - 176 . Correspondence Lin-Cheng Yang MD , Associate Professor , Gene Therapy Laboratory, Tajen Institute of Technology, Pingtung, 907

Cellular immunotherapy using irradiated lung cancer cell vaccine co-expressing GM-CSF and IL-18 can induce significant antitumor effects

Hongwei Tian 0 Gang Shi 0 Guoyou Yang Junfeng Zhang Yiming Li Tao Du Jianzhou Wang Fen Xu Lin Cheng Xiaomei Zhang Lei Dai Xiaolei Chen Shuang Zhang Yang Yang Dechao Yu Yuquan Wei Hongxin Deng 0

RNA-binding protein RNPC1: acting as a tumor suppressor in breast cancer

Jin-Qiu Xue 0 Tian-Song Xia 0 Xiu-Qing Liang Wenbin Zhou Lin Cheng Liang Shi Ying Wang Qiang Ding 0 Equal contributors Jiangsu Breast Disease Center, the First Affiliated Hospital with Nanjing

Visual gene-network analysis reveals the cancer gene co-expression in human endometrial cancer

Background Endometrial cancers (ECs) are the most common form of gynecologic malignancy. Recent studies have reported that ECs reveal distinct markers for molecular pathogenesis, which in turn is linked to the various histological types of ECs. To understand further the molecular events contributing to ECs and endometrial tumorigenesis in general, a more precise identification of...

MAGIC Study: Aims, Design and Methods using SystemCHANGE™ to Improve Immunosuppressive Medication Adherence in Adult Kidney Transplant Recipients

Shirley Moore 3 Donna Hathaway 1 An-Lin Cheng 0 Guoqing Chen 5 Kathy Goggin 4 0 School of Nursing and Health Studies, University of Missouri-Kansas City , Health Sciences Building 2407, Kansas City, MO

Treadmill exercise enhances therapeutic potency of transplanted bone mesenchymal stem cells in cerebral ischemic rats via anti-apoptotic effects

Background The transplantation of bone marrow stromal cells (MSCs) has proved to ameliorate ischemic brain injury in animals, but most transplanted MSCs undergo apoptosis in the ischemic penumbra, greatly compromising the therapeutic value of this treatment. Meanwhile, cell apoptosis can be inhibited by post-ischemia exercise which has been demonstrated to improve the expression...

Intrathecal bupivacaine with morphine or neostigmine for postoperative analgesia after total knee replacement surgery

Ping-Heng Tan Yuan-Yi Chia Yuan Lo Kang Liu Lin-Cheng Yang Tsung-Hsing Lee [L'administration intrathcale de bupivacane avec morphine ou nostigmine comme analgsie postopratoire suivant la mise en

Podocalyxin-like 1 promotes invadopodia formation and metastasis through activation of Rac1/Cdc42/cortactin signaling in breast cancer cells

Metastatic disease is the leading cause of cancer mortality. Identifying biomarkers and regulatory mechanisms is important toward developing diagnostic and therapeutic tools against metastatic cancer. In this study, we demonstrated that podocalyxin-like 1 (PODXL) is overexpressed in breast tumor cells and increased in lymph node metastatic cancer. Mechanistically, we found that...

GPR48, a poor prognostic factor, promotes tumor metastasis and activates β-catenin/TCF signaling in colorectal cancer

G-protein-coupled receptor 48 (GPR48) is an orphan receptor belonging to the G-protein-coupled receptors family, which plays an important role in the development of various organs and cancer development and progression such as gastric cancer and colorectal cancer (CRC). However, the prognostic value of GPR48 expression in patients with CRC has not been reported. In this study, we...

An unusual function of RON receptor tyrosine kinase as a transcriptional regulator in cooperation with EGFR in human cancer cells

Homodimerization of RON (MST1R), a receptor tyrosine kinase, usually occurs in cells stimulated by a ligand and leads to the downstream activation of signaling pathways. Here we report that bladder cancer cells, in response to physiological stress, use an alternative mechanism for signaling activation. Time-course studies indicated that RON migrated directly from the membrane to...

Role of Benzathine Penicillin G in Prophylaxis for Recurrent Streptococcal Cellulitis of the Lower Legs

Cellulitis of the lower leg is an infection caused by streptococci or, less commonly, Staphylococcus aureus and other gram-negative rods. Recurrence of cellulitis is a common problem. In the present study, we evaluated the use of monthly intramuscular injections of benzathine penicillin G to prevent recurrences of cellulitis. A total of 115 patients with definite or presumptive...

Skin and Soft-Tissue Manifestations of Shewanella putrefaciens Infection

Shewanella putrefaciens, a saprophytic gram-negative rod, is infrequently recovered from clinical specimens. Although a number of clinical syndromes have been attributed to S. putrefaciens, the pathogenic role of this agent remains largely undefined. We report 16 cases of S. putrefaciens infection that occurred at the Veterans General Hospital—Kaohsiung in Taiwan between 1990 and...

Mycotic Aneurysm Due to Non-typhi Salmonella: Report of 16 Cases

From 1990 through 1994, we collected information on all cases of mycotic aneurysms due to non-typhi Salmonella that occurred at the Veterans General Hospital in Kaohsiung, Taiwan. All cases of salmonella bacteremia were reviewed to find any additional cases. A total of 16 cases of salmonella mycotic aneurysms occurred. The mortality rate was 100% among the three patients treated...

T cell immunohistochemistry refines lung transplant acute rejection diagnosis and grading

Objective Lung transplant volume has been increasing. However, inaccurate and uncertain diagnosis for lung transplant rejection hurdles long-term outcome due to, in part, interobserver variability in rejection grading. Therefore, a more reliable method to facilitate diagnosing and grading rejection is warranted. Method Rat lung grafts were harvested on day 3, 7, 14 and 28 post...

Genomes of the rice pest brown planthopper and its endosymbionts reveal complex complementary contributions for host adaptation

Background The brown planthopper, Nilaparvata lugens, the most destructive pest of rice, is a typical monophagous herbivore that feeds exclusively on rice sap, which migrates over long distances. Outbreaks of it have re-occurred approximately every three years in Asia. It has also been used as a model system for ecological studies and for developing effective pest management. To...

Improving early infant HIV diagnosis in Kenya: study protocol of a cluster-randomized efficacy trial of the HITSystem

Background Early infant diagnosis among human immunodeficiency virus (HIV)-exposed infants is a critical component of prevention of mother-to-child transmission programs. Barriers to early infant diagnosis include poor uptake, low retention at designated re-testing intervals, delayed test results, passive systems of communication, and poor linkage to treatment. This study will...

In situ observation of austenite grain growth behavior in the simulated coarse-grained heat-affected zone of Ti-microalloyed steels

Huang Ran Wei Lin Cheng The austenite grain growth behavior in a simulated coarse-grained heat-affected zone during thermal cycling was investigated via in situ observation. Austenite grains nucleated at

Up-regulation of S100A16 expression promotes epithelial-mesenchymal transition via Notch1 pathway in breast cancer

Background Our previous studies demonstrated that S100A16 promotes adipogenesis and is involved in weight gain attenuation induced by dietary calcium. Till now, the function of S100A16 in the breast cancer remains to be elucidated. Results In this study, we observed that S100A16 was expressed in higher levels in human breast cancer tissues compared with paired adjacent non...