This work compares the optical microwave photoconductivity decay (μPCD) and electrical open-circuit voltage decay (OCVD) techniques for measuring the ambipolar carrier lifetime in 4H-silicon carbide (4H-SiC) epitaxial layers. Lifetime measurements were carried out by fabricating P+/intrinsic/N+ (PiN) diodes on 100-μm-thick, 1 × 1014 cm−3 to 4.5 × 1014 cm−3 doped N-type 4 H-SiC...
Understanding network features of brain pathology is essential to reveal underpinnings of neurodegenerative diseases. In this paper, we introduce a novel graph regression model (GRM) for learning structural brain connectivity of Alzheimer's disease (AD) measured by amyloid-β deposits. The proposed GRM regards 11C-labeled Pittsburgh Compound-B (PiB) positron emission tomography...
Exosomes are nanoparticles(40-100 nm) secreted by most cells in the body, which can be isolated from several types of extracellular fluids. It has been shown that exosomes play a key role in intercellular communication and in transportation of genetic information. Emerging evidence shows that exosomes are mediators of metastasis in tumour cells, stromal cells and the...
Exosomes are nanoparticles(40-100 nm) secreted by most cells in the body, which can be isolated from several types of extracellular fluids. It has been shown that exosomes play a key role in intercellular communication and in transportation of genetic information. Emerging evidence shows that exosomes are mediators of metastasis in tumour cells, stromal cells and the...
Exosomes are nanoparticles(40-100 nm) secreted by most cells in the body, which can be isolated from several types of extracellular fluids. It has been shown that exosomes play a key role in intercellular communication and in transportation of genetic information. Emerging evidence shows that exosomes are mediators of metastasis in tumour cells, stromal cells and the...
reproduction in any medium, provided the original author(s) and the source are credited. Author Biographies Lin CHENG (M’05) was born in 1973. He received the B.S. degree from Tianjin University, Tianjin, China
Homodimerization of RON (MST1R), a receptor tyrosine kinase, usually occurs in cells stimulated by a ligand and leads to the downstream activation of signaling pathways. Here we report that bladder cancer cells, in response to physiological stress, use an alternative mechanism for signaling activation. Time-course studies indicated that RON migrated directly from the membrane to...
Background Anesthetic propofol has immunomodulatory effects, particularly in the area of anti-inflammation. Bacterial endotoxin lipopolysaccharide (LPS) induces inflammation through toll-like receptor (TLR) 4 signaling. We investigated the molecular actions of propofol against LPS/TLR4-induced inflammatory activation in murine RAW264.7 macrophages. Methodology/Principal Findings...
Background and Objective Genetic factors are important in the pathogenesis of fractures. Notably, estrogen receptor α (ESR1) has been suggested as a possible candidate gene for hip fractures; however, published studies of ESR1 gene polymorphisms have been hampered by small sample sizes and inconclusive or ambiguous results. The aim of this meta-analysis is to investigate the...
As the β-catenin pathway has been shown to be involved in mechanotransduction, we sought to determine if haploinsufficiency would affect skeletal response to unloading. It has previously been shown that deletion of both alleles of β-catenin in bone cells results in a fragile skeleton highly susceptible to fracture, but deletion of one allele using Dmp1-Cre (Ctnnb1+/loxP; Dmp1-Cre...
Introduction and Aims:In patients with chronic renal failure, secondary hyperparathyroidism (sHPT) sometimes requires parathyroidectomy. Prospectively, we compared total parathyroidectomy without autotransplantation and without thymectomy (tPTX) with subtotal parathyreoidectomy with thymectomy (sPTX) for renal hyperparathyroidism. Methods:From 11/2004 to 11/2008, 43 consecutive...
Glioblastomas (GBMs) are highly lethal primary brain tumors. Despite current therapeutic advances in other solid cancers, the treatment of these malignant gliomas remains essentially palliative. GBMs are extremely resistant to conventional radiation and chemotherapies. We and others have demonstrated that a highly tumorigenic subpopulation of cancer cells called GBM stem cells...
There is growing evidence that severe decline of skeletal muscle mass and function with age may be mitigated by exercise and dietary supplementation with protein and amino acid ingredient technologies. The purposes of this study were to examine the effects of the leucine catabolite, beta-hydroxy-beta-methylbutyrate (HMB), in C2C12 myoblasts and myotubes, and to investigate the...
Hongwei Tian 0 Gang Shi 0 Guoyou Yang Junfeng Zhang Yiming Li Tao Du Jianzhou Wang Fen Xu Lin Cheng Xiaomei Zhang Lei Dai Xiaolei Chen Shuang Zhang Yang Yang Dechao Yu Yuquan Wei Hongxin Deng 0
Background The chemokine CXCL14 has been reported to play an important role in the progression of many malignancies such as breast cancer and papillary thyroid carcinoma, but the role of CXCL14 in colorectal carcinoma (CRC) remains to be established. The purpose of this study was to investigate the expression pattern and significance of CXCL14 in CRC progression. Method 265...
epithelial; TGF-β, transforming growth factor beta; VPA, valproic acid. COMPLIANCE WITH ETHICS GUIDELINES Lin Cheng and Yuewen Tang declare that they have no conflict of interest. All institutional and
study Jiajia Guo 0 Houpu Yang 0 Shu Wang Yingming Cao Miao Liu Fei Xie Peng Liu Bo Zhou Fuzhong Tong Lin Cheng Hongjun Liu Siyuan Wang 0 Equal contributors Peking University People's Hospital Breast
Severe asymptomatic stenosis of the internal carotid artery (ICA) leads to increased incidence of mild cognitive impairment (MCI) likely through silent embolic infarcts and/or chronic hypoperfusion, but the brain dysfunction is poorly understood and difficult to diagnose. Thirty cognitively intact subjects with asymptomatic, severe (≧70%), unilateral stenosis of the ICA were...
Background This randomized phase III study was to evaluate the efficacy and safety of cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) for the treatment of peritoneal carcinomatosis (PC) from gastric cancer. Methods Sixty-eight gastric PC patients were randomized into CRS alone (n = 34) or CRS + HIPEC (n = 34) receiving cisplatin 120 mg and...
The Alpha Magnetic Spectrometer (AMS) is an instrument for the international scientific experiment, composed of six detectors and 650 micro-electronics. The objective of AMS experiment is to search for dark matter and anti-matter in space. In this paper, the thermal control system for AMS cryocoolers is designed, analyzed and experimentally studied. Using loop heat pipes (LHPs...
