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MiRNAs of peripheral blood as the biomarker of schizophrenia

The diagnosis of schizophrenia is currently based on the symptoms and bodily signs rather than on the pathological and physiological markers of the patient. In the search for new molecular targeted therapy medicines, and recurrence of early-warning indicators have become the major focus of contemporary research, because they improve diagnostic accuracy. Biomarkers reflect the...

JMJD6 promotes melanoma carcinogenesis through regulation of the alternative splicing of PAK1, a key MAPK signaling component

Melanoma, originated from melanocytes located on the basal membrane of the epithelial tissue, is the most aggressive form of skin cancer that accounts for 75% of skin cancer-related death. Although it is believed that BRAF mutation and the mitogen-activated protein kinase (MAPK) pathway play critical roles in the pathogenesis of melanoma, how the MAPK signaling is regulated in...

JMJD6 promotes melanoma carcinogenesis through regulation of the alternative splicing of PAK1, a key MAPK signaling component

Melanoma, originated from melanocytes located on the basal membrane of the epithelial tissue, is the most aggressive form of skin cancer that accounts for 75% of skin cancer-related death. Although it is believed that BRAF mutation and the mitogen-activated protein kinase (MAPK) pathway play critical roles in the pathogenesis of melanoma, how the MAPK signaling is regulated in...

Origin of room-temperature single-channel ballistic transport in zigzag graphene nanoribbons

Austin, USA. His research interests include light-induced phase transition in transition-metal dichalcogenides and perovskite materials. Lin He received his PhD degree from the Department of Physics

Challenges and Innovative Solutions in Urban Rail Transit Network Operations and Management: China’s Guangzhou Metro Experience

Urban rail transit operations have changed from a single line to a multiline network. The network operations have undergone quantitative and qualitative changes, and operations management is facing rapid internal and external changes. Using the Guangzhou Metro network operation practices as a case study, this paper first systematically analyzes the features of the operation scale...

The Role of Annealing Process in Ag-Based BaSnO3 Multilayer Thin Films

The BaSnO3/Ag/BaSnO3 multilayer structure was designed and fabricated on a quartz glass by magnetron sputtering, followed by an annealing process at a temperature from 150 to 750 °C in air. In this paper, we investigated the influence of the annealing temperature on the structural, optical, and electrical properties of the multilayers and proposed the mechanisms of conduction and...

Genetic risk between the CACNA1I gene and schizophrenia in Chinese Uygur population

. Author Wei Xu wrote the first draft of the manuscript, while Yongyong Shi, Qizhong Yi and Lin He supervised the whole research process. All authors contributed to and have approved the final manuscript

The application of trigonal curve theory to the second-order Benjamin-Ono hierarchy

Guoliang He 0 Lin He 1 0 Department of Mathematics and Information Science, Zhengzhou University of Light Industry , Zhengzhou, 450002 , China 1 Department of Economics, Zhengzhou Vocational College

An expanding universe of the non-coding genome in cancer biology

Neoplastic transformation is caused by accumulation of genetic and epigenetic alterations that ultimately convert normal cells into tumor cells with uncontrolled proliferation and survival, unlimited replicative potential and invasive growth [Hanahan,D. et al. (2011) Hallmarks of cancer: the next generation. Cell, 144, 646–674]. Although the majority of the cancer studies have...

A Novel Top-k Strategy for Influence Maximization in Complex Networks with Community Structure

In complex networks, it is of great theoretical and practical significance to identify a set of critical spreaders which help to control the spreading process. Some classic methods are proposed to identify multiple spreaders. However, they sometimes have limitations for the networks with community structure because many chosen spreaders may be clustered in a community. In this...

Integration of fuzzy theory into Kano model for classification of service quality elements: A case study in a machinery industry of China

Purpose: The purpose of study is to meet customer requirements and improve customer satisfaction that aims to classify customer requirements more effectively. And the classification is focused on the customer psychology. Design/methodology/approach: In this study, considering the advantages of Kano model in taking into account both customer’s consuming psychology and motivation...

Echocardiographic diagnosis of rare pathological patterns of sinus of Valsalva aneurysm

Objective To evaluate the value and improve the diagnostic accuracy of echocardiography in the diagnosis of a sinus of Valsalva aneurysm (SVA) with rare pathological patterns. Methods Echocardiographic features and surgical findings from 270 Chinese patients with SVA treated in the last 18 years (1995–2013) at the Union Hospital were compared retrospectively; 22 of 270 cases had...

Prevalence of condomless anal intercourse and recent HIV testing and their associated factors among men who have sex with men in Hangzhou, China: A respondent-driven sampling survey

Men who have sex with men (MSM) are a large high-risk population for HIV infection in recent years in China. A cross-sectional survey was conducted in Hangzhou, China, to determine rates of condomless anal intercourse (CAI), recent HIV testing (in the recent year) and associated factors using respondent-driven sampling. Questionnaires using face-to-face interviews were employed...

Prevalence of prior HIV testing and associated factors among MSM in Zhejiang Province, China: a cross-sectional study

Lin He 0 Tingting Jiang 0 Dayong Wang Yan Zhang Xingliang Zhang Shichang Xia 0 0 Zhejiang Provincial Center for Disease Control and Prevention , No.3399, Binsheng Road, Hangzhou, Zhejiang Province

A Novel Supra-Brow Combined with Infra-Brow Lift Approach for Asian Women

between the upper eyelid edge and the eyebrow. In follow-up visits, 409 Eyebrows; Rhytidoplasty; Suture techniques; Cicatrix; Blepharoplasty - Maoguo Shu and Lin He have contributed equally to this work

Three-Dimensional Rotation, Twist and Torsion Analyses Using Real-Time 3D Speckle Tracking Imaging: Feasibility, Reproducibility, and Normal Ranges in Pediatric Population

Background and Objective The specific aim of this study was to evaluate the feasibility, reproducibility and maturational changes of LV rotation, twist and torsion variables by real-time 3D speckle-tracking echocardiography (RT3DSTE) in children. Methods A prospective study was conducted in 347 consecutive healthy subjects (181 males/156 females, mean age 7.12 ± 5.3 years, and...

Inhibition of STAT3- and MAPK-dependent PGE 2 synthesis ameliorates phagocytosis of fibrillar β-amyloid peptide (1-42) via EP2 receptor in EMF-stimulated N9 microglial cells

Background Prostaglandin E 2 (PGE 2 )-involved neuroinflammatory processes are prevalent in several neurological conditions and diseases. Amyloid burden is correlated with the activation of E-prostanoid (EP) 2 receptors by PGE 2 in Alzheimer’s disease. We previously demonstrated that electromagnetic field (EMF) exposure can induce pro-inflammatory responses and the depression of...

Landau quantization of Dirac fermions in graphene and its multilayers

When electrons are confined in a two-dimensional (2D) system, typical quantum–mechanical phenomena such as Landau quantization can be detected. Graphene systems, including the single atomic layer and few-layer stacked crystals, are ideal 2D materials for studying a variety of quantum–mechanical problems. In this article, we review the experimental progress in the unusual Landau...