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Highly efficient frequency doubling and quadrupling of a short-pulsed thulium fiber laser

We report the second harmonic generation and fourth harmonic generation of the output from a short-pulsed (~ 80 ps) thulium-doped fiber laser, generating 976 and 488 nm wavelengths with high efficiency. With a narrow-linewidth (0.5 nm) pump at a power of 3.2 W, a second harmonic power of 2.4 W was generated at 976 nm with a conversion efficiency reaching 75%. For FHG, 690 mW of...

High relative risk of all-cause mortality attributed to smoking in China: Guangzhou Biobank Cohort Study

Contributions Conceptualization: Tai Hing Lam, Lin Xu, Chao Qiang Jiang, Kar Keung Cheng. Data curation: Tai Hing Lam, Chao Qiang Jiang, Feng Zhu, Ya Li Jin, Kar Keung Cheng. Formal analysis: Tai Hing Lam ... . Investigation: Tai Hing Lam. Funding acquisition: Tai Hing Lam, Wei Sen Zhang, G. Neil Thomas. Methodology: Tai Hing Lam, Lin Xu, Chao Qiang Jiang, Kar Keung Cheng. Project administration: Tai Hing Lam, Lin Xu

The role of glycaemic and lipid risk factors in mediating the effect of BMI on coronary heart disease: a two-step, two-sample Mendelian randomisation study

Aims/hypothesis The extent to which effects of BMI on CHD are mediated by glycaemic and lipid risk factors is unclear. In this study we examined the effects of these traits using genetic evidence. Methods We used two-sample Mendelian randomisation to determine: (1) the causal effect of BMI on CHD (60,801 case vs 123,504 control participants), type 2 diabetes (34,840 case vs 114...

Prescription practice of anti-tuberculosis drugs in Yunnan, China: A clinical audit

programme (by body weight) and WHO (mg/kg). (DOCX) Author Contributions Conceptualization: Lin Xu, Jinou Chen, Anh L. Innes, Ling Li, Chen-Yuan Chiang. Data curation: Jinou Chen, Chen-Yuan Chiang. Formal ... analysis: Jinou Chen, Chen-Yuan Chiang. Funding acquisition: Lin Xu, Anh L. Innes, Ling Li. Investigation: Lin Xu, Jinou Chen, Anh L. Innes, Chen-Yuan Chiang. Methodology: Lin Xu, Anh L. Innes, Chen-Yuan

Study of the numerical simulation of tight sandstone gas molecular diffusion based on digital core technology

Diffusion is an important mass transfer mode of tight sandstone gas. Since nano-pores are extensively developed in the interior of tight sandstone, a considerable body of research indicates that the type of diffusion is mainly molecular diffusion based on Fick’s law. However, accurate modeling and understanding the physics of gas transport phenomena in nano-porous media is still...

Complete genome sequence of esterase-producing bacterium Croceicoccus marinus E4A9T

Croceicoccus marinus E4A9Twas isolated from deep-sea sediment collected from the East Pacific polymetallic nodule area. The strain is able to produce esterase, which is widely used in the food, perfume, cosmetic, chemical, agricultural and pharmaceutical industries. Here we describe the characteristics of strain E4A9, including the genome sequence and annotation, presence of...

Epidemiology characteristics of human coronaviruses in patients with respiratory infection symptoms and phylogenetic analysis of HCoV-OC43 during 2010-2015 in Guangzhou

samples and clinical information. Author Contributions Conceptualization: Kai-yuan Cao, Lin Xu. Data curation: Xun Zhu, Ding-mei Zhang. Funding acquisition: Kwok-yung Yuen, Meng-feng Li. Investigation ... ± original draft: Lin Xu. Writing ± review & editing: Bo-jian Zheng, Kai-yuan Cao. 18 / 20 15. WHO. CDC protocol of real time RTPCR for influenza A (H1N1), 6 October 2009. Available from: http://

Correction to: Gender difference in acquired seizure susceptibility in adult rats after early complex febrile seizures

In the original publication of the article, the representative EEG of female rat pups with FS in Figure 1 C and D was incorrectly intercepted from that of male rat pups. This correction does not affect the conclusions of the paper. Figure 1 has been corrected on the online PDF version and displayed below.

Devosia nitraria sp. nov., a novel species isolated from the roots of Nitraria sibirica in China

An aerobic, Gram-stain negative, short rod-shaped and motile strain, 36-5-1T, was isolated from the roots of Nitraria sibirica in Zhangye city, Gansu province, north-west of China. Phylogenetic analysis based on the 16S rRNA gene sequence and two housekeeping genes (glnA and atpD) indicated that the strain represents a novel species closely related to the Devosia, Rhizobium and...

Physiological and genomic features of a novel violacein-producing bacterium isolated from surface seawater

Strains JW1T and JW3, isolated from surface seawater of the Arabian Sea, were subjected to polyphasic taxonomic analysis. Cells of both strains were Gram-stain-negative, aerobic, and rod-shaped. They formed violet pigment and produced violacein. On the basis of 16S rRNA gene sequence analysis, strains JW1T and JW3 showed high 16S rRNA gene sequence similarity with...

Bruch´s membrane thickness in relationship to axial length

the study. (SAV) Author Contributions Conceptualization: Hai Xia Bai, Bin Li, Jost B. Jonas. Data curation: Hai Xia Bai, Ying Mao, Ling Shen, Xiao Lin Xu, Fei Gao, Zhi Bao Zhang, Bin Li, Jost B ... . Jonas. Formal analysis: Hai Xia Bai, Ying Mao, Ling Shen, Xiao Lin Xu, Fei Gao, Zhi Bao Zhang, Jost B. Jonas. Funding acquisition: Bin Li. Investigation: Hai Xia Bai, Ying Mao, Ling Shen, Xiao Lin Xu

Complete genome sequence of bacteriochlorophyll-synthesizing bacterium Porphyrobacter neustonensis DSM 9434

The genus Porphyrobacter belongs to aerobic anoxygenic phototrophic bacteria cluster. Porphyrobacter neustonensis DSM 9434 was isolated from a eutrophic freshwater pond in Australia, and is able to synthesize Bacteriochlorophyll a as well as grow under aerobic conditions. It is the type species of the genus Porphyrobacter. Here we describe the characteristics of the strain DSM...

Arabidopsis PRC1 core component AtRING1 regulates stem cell-determining carpel development mainly through repression of class I KNOX genes

Background Polycomb repressive complex 2 (PRC2)-catalyzed H3K27me3 marks are tightly associated with the WUS-AG negative feedback loop to terminate floral stem cell fate to promote carpel development, but the roles of Polycomb repressive complex 1 (PRC1) in this event remain largely uncharacterized. Results Here we show conspicuous variability in the morphology and number of...

DHA Production in Escherichia coli by Expressing Reconstituted Key Genes of Polyketide Synthase Pathway from Marine Bacteria

The gene encoding phosphopantetheinyl transferase (PPTase), pfaE, a component of the polyketide synthase (PKS) pathway, is crucial for the production of docosahexaenoic acid (DHA, 22:6ω3), along with the other pfa cluster members pfaA, pfaB, pfaC and pfaD. DHA was produced in Escherichia coli by co-expressing pfaABCD from DHA-producing Colwellia psychrerythraea 34H with one of...

Growth characteristics of freeze-tolerant baker’s yeast Saccharomyces cerevisiae AFY in aerobic batch culture

Lin Xu xulin@njtech 0 0 College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University , Jiangsu 211800 , China 1 Faculty of Bioresource Science, Akita Prefectural University , Akita

Dynamic Epistasis under Varying Environmental Perturbations

Epistasis describes the phenomenon that mutations at different loci do not have independent effects with regard to certain phenotypes. Understanding the global epistatic landscape is vital for many genetic and evolutionary theories. Current knowledge for epistatic dynamics under multiple conditions is limited by the technological difficulties in experimentally screening epistatic...

Implantable porous gelatin microspheres sustained release of bFGF and improved its neuroprotective effect on rats after spinal cord injury

In this study, porous gelatin microspheres (GMSs) were constructed to improve the neuroprotective effect of basic fibroblast growth factor (bFGF) on spinal cord injury. GMSs were prepared by a W/O emulsion template, followed by cross-linking, washing and drying. The particle sizes and surface porosity of the blank GMSs were carefully characterized by scan electronic microscopy...