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Search: authors:"Lin-Li Lv"

10 papers found.
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Are Urinary Tubular Injury Markers Useful in Chronic Kidney Disease? A Systematic Review and Meta Analysis

Background Adverse outcome of chronic kidney disease, such as end stage renal disease, is a significant burden on personal health and healthcare costs. Urinary tubular injury markers, such as NGAL, KIM-1 and NAG, could provide useful prognostic value for the early identification of high-risk patients. However, discrepancies between recent large prospective studies have resulted in ...

Interleukin-1β mediates high glucose induced phenotypic transition in human aortic endothelial cells

Background Previous studies have shown that high glucose (HG) induced endothelial cell (EC) damage via a phenotypic transition of EC. There is increasing evidence suggesting the role of inflammatory cytokines in mediated HG-induced EC damage. However, little is known about the potential role of interleukin-1β (IL-1β) in the process. The aim of present study was to investigate ...

Improved Mitochondrial Function Underlies the Protective Effect of Pirfenidone against Tubulointerstitial Fibrosis in 5/6 Nephrectomized Rats

Dysfunctional mitochondria participate in the progression of chronic kidney disease (CKD). Pirfenidone is a newly identified anti-fibrotic drug. However, its mechanism remains unclear. Mitochondrial dysfunction is an early event that occurs prior to the onset of renal fibrosis. In this context, we investigated the protective effect of pirfenidone on mitochondria and its relevance ...

Activation of renin-angiotensin system is involved in dyslipidemia-mediated renal injuries in apolipoprotein E knockout mice and HK-2 cells

Background Dyslipidemia and activation of renin-angiotensin system (RAS) contribute to the progression of chronic kidney disease (CKD). This study investigated possible synergistic effects of intrarenal RAS activation with hyperlipidemia in renal injuries. Methods Apolipoprotein knockout mice were fed with normal chow diet (control) or high fat diet (HF group) for eight weeks. ...

Urinary Podocyte-Associated mRNA profile in Various Stages of Diabetic Nephropathy

Background Podocyte injury and subsequent excretion in urine play a crucial role in the pathogenesis and progression of diabetic nephropathy (DN). Quantification of messenger RNA (mRNA) expression in urinary sediment by real-time PCR is emerging as a noninvasive method of screening DN-associated biomarkers. We hypothesized that the urinary mRNA profile of podocyte-associated ...

A Pilot Trial Assessing Urinary Gene Expression Profiling with an mRNA Array for Diabetic Nephropathy

Background The initiation and progression of diabetic nephropathy (DN) is complex. Quantification of mRNA expression in urinary sediment has emerged as a novel strategy for studying renal diseases. Considering the numerous molecules involved in DN development, a high-throughput platform with parallel detection of multiple mRNAs is needed. In this study, we constructed a ...

Lupus nephritis

Introduction and Aims: NLRP3/ASC inflammasome signaling translates infectious and sterile dangers into the secretion of mature IL-1β and IL-18 and subsequently into IL-1R/NF-κB-dependent secretion of multiple pro-inflammatory cytokines. We hypothesized that the NLRP3/ASC inflammasome would contribute in a similar manner to autoimmune tissue inflammation, e.g. to immune complex ...

Biomarkers

Introduction and Aims: The stratification of chronic kidney disease (CKD) patients, to identify those at high risk of poor outcomes, requires tests that individually assess kidney function, kidney injury and systemic inflammation. Due to the limitations of the individual markers, here we evaluate a marker of immune status and kidney function, combined polyclonal serum free light ...

Pathophysiology and clinical studies in CKD 1-5

Introduction and Aims: Transcatheter aortic valve replacement (TAVR) is an established percutaneous technique for the management of patients with severe symptomatic aortic stenosis at high operative risk with or without chronic kidney disease (CKD). Iodine contrast administration, rapid cardiac pacing and use of large core catheters in putative calcified arteries are among the most ...

Lab methods / biomarkers

Introduction and Aims:Patients with Chronic Kidney Disease (CKD) and/or Diabetes are at a high risk for cardiovascular (CV) disease. Improved outcomes require a better understanding of specific risk factors that distinctly modulate the incidence of atheromatous disease. Herein. we compared the distinct and combined impact of CKD and of diabetes (DM) on the development of ...