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Identification of natural products as novel ligands for the human 5-HT2C receptor

Cheng, Suwen Zhao, Ling Shen, Raymond C. Stevens, Jun Ma, Ronald J. Quinn, Guisheng Zhong , and Zhi-Jie Liu declare that they have no conflict of interest G protein-coupled receptors (GPCRs) constitute

Bruch´s membrane thickness in relationship to axial length

the study. (SAV) Author Contributions Conceptualization: Hai Xia Bai, Bin Li, Jost B. Jonas. Data curation: Hai Xia Bai, Ying Mao, Ling Shen, Xiao Lin Xu, Fei Gao, Zhi Bao Zhang, Bin Li, Jost B ... . Jonas. Formal analysis: Hai Xia Bai, Ying Mao, Ling Shen, Xiao Lin Xu, Fei Gao, Zhi Bao Zhang, Jost B. Jonas. Funding acquisition: Bin Li. Investigation: Hai Xia Bai, Ying Mao, Ling Shen, Xiao Lin Xu

Effect of oral melatonin and wearing earplugs and eye masks on nocturnal sleep in healthy subjects in a simulated intensive care unit environment: which might be a more promising strategy for ICU sleep deprivation?

Introduction Sleep deprivation is common in critically ill patients in the intensive care unit (ICU). Noise and light in the ICU and the reduction in plasma melatonin play the essential roles. The aim of this study was to determine the effect of simulated ICU noise and light on nocturnal sleep quality, and compare the effectiveness of melatonin and earplugs and eye masks on sleep...

Impact of oral melatonin on critically ill adult patients with ICU sleep deprivation: study protocol for a randomized controlled trial

Background Sleep deprivation is common in critically ill patients in intensive care units (ICU). It can result in delirium, difficulty weaning, repeated nosocomial infections, prolonged ICU length of stay and increased ICU mortality. Melatonin, a physiological sleep regulator, is well known to benefit sleep quality in certain people, but evidence for the effectiveness in ICU...

Novel Inducers of Fetal Globin Identified through High Throughput Screening (HTS) Are Active In Vivo in Anemic Baboons and Transgenic Mice

High-level fetal (γ) globin expression ameliorates clinical severity of the beta (β) hemoglobinopathies, and safe, orally-bioavailable γ-globin inducing agents would benefit many patients. We adapted a LCR-γ-globin promoter-GFP reporter assay to a high-throughput robotic system to evaluate five diverse chemical libraries for this activity. Multiple structurally- and functionally...

A Triterpenoid Inhibited Hormone-Induced Adipocyte Differentiation and Alleviated Dexamethasone-Induced Insulin Resistance in 3T3-L1 adipocytes

Hu . Juan Zhou . Lin-Chun Fu . Ru-Hua Tian . Shan Liu . Gang Xu . Xiao-Ling Shen 0 1 0 J.-Z. Ma X.-W. Yang G. Xu (&) State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming

Relationship between P53 Status and Response to Chemotherapy in Patients with Gastric Cancer: A Meta-Analysis

Background Previous studies have yielded conflicting results regarding the relationship between p53 status and response to chemotherapy in patients with gastric cancer. We therefore performed a meta-analysis to expound the relationship between p53 status and response to chemotherapy. Methods/Findings Thirteen previously published eligible studies, including 564 cases, were...

Sensitization of Human Pancreatic Cancer Cells Harboring Mutated K-ras to Apoptosis

Pancreatic cancer is a devastating human malignancy and gain of functional mutations in K-ras oncogene is observed in 75%–90% of the patients. Studies have shown that oncogenic ras is not only able to promote cell growth or survival, but also apoptosis, depending upon circumstances. Using pancreatic cancer cell lines with or without expressing mutated K-ras, we demonstrated that...

Sterols and Terpenoids from Viburnum odoratissimum

Abstract A new stigmasterol type natural product, viburodorol A (1), along with eleven known sterols and terpenoids (2–12), were isolated from the aerial parts of Viburnum odoratissimum. The structure of 1 was elucidated on the basis of comprehensive spectroscopic analysis. It’s noteworthy that compound 2, the major constituent of this plant, can significantly stimulate glucose...

The Protective Effect of Intrasplenic Transplantation of Ad-IL-18BP/IL-4 Gene-Modified Fetal Hepatocytes on ConA-Induced Hepatitis in Mice

Background Concanavalin A (ConA)-induced hepatitis is an experimental murine model mirroring the pathology of human autoimmune hepatitis. Aim To investigate the effects of intrasplenically transplanted fetal hepatocytes (BNL.CL2) transfected with recombinant adenovirus vector expressing the IL-18 binding protein (IL-18BP) and IL-4 fusion protein on ConA-induced hepatitis in mice...

Imputation of the Rare HOXB13 G84E Mutation and Cancer Risk in a Large Population-Based Cohort

An efficient approach to characterizing the disease burden of rare genetic variants is to impute them into large well-phenotyped cohorts with existing genome-wide genotype data using large sequenced referenced panels. The success of this approach hinges on the accuracy of rare variant imputation, which remains controversial. For example, a recent study suggested that one cannot...

Phosphoantigen/IL2 Expansion and Differentiation of Vγ2Vδ2 T Cells Increase Resistance to Tuberculosis in Nonhuman Primates

Dominant Vγ2Vδ2 T-cell subset exist only in primates, and recognize phosphoantigen from selected pathogens including M. tuberculosis(Mtb). In vivo function of Vγ2Vδ2 T cells in tuberculosis remains unknown. We conducted mechanistic studies to determine whether earlier expansion/differentiation of Vγ2Vδ2 T cells during Mtb infection could increase immune resistance to tuberculosis...

SHIV Antigen Immunization Alters Patterns of Immune Responses to SHIV/Malaria Coinfection and Protects against Life-Threatening SHIV-Related Malaria

Whether vaccination against a virus can protect against more virulent coinfection with the virus and additional pathogen(s) remains poorly characterized. Overlapping endemicity of human immunodeficiency virus (HIV) and malaria suggests that HIV/malaria coinfection frequently complicates acute and chronic HIV infection. Here we showed that vaccination of macaques with recombinant...

Antiobesity and Antihyperglycemic Effects of Ginsenoside Rb1 in Rats

Ye Xiong Ling Shen Kristina J. Liu Patrick Tso Yuqing Xiong Guangji Wang Stephen C. Woods Min Liu OBJECTIVE-Obesity and type 2 diabetes are national and worldwide epidemics. Because currently

neo-Clerodane diterpenoids from Salvia dugesii and their bioactive studies

Salvia dugesii is an invasive plant in Yunnan, China. To tentatively explore its utilization, a systematic phytochemical investigation was carried out on this plant, which led to the isolation of five new neo-clerodane diterpenoids, dugesins C–G (1–5), together with six known ones. Their structures were determined by comprehensive NMR and MS spectroscopic analysis. It was...

Tim-3-Expressing CD4+ and CD8+ T Cells in Human Tuberculosis (TB) Exhibit Polarized Effector Memory Phenotypes and Stronger Anti-TB Effector Functions

Hongying Liao Yan Zhang Hua Wang Shaoyuan Li Yanfen Luo Danyun Fang Guobao Li Boping Zhou Ling Shen Crystal Y. Chen Dan Huang Jiye Cai Kaiyuan Cao Lifang Jiang Gucheng Zeng Zheng W. Chen David M. Lewinsohn

Role of Scrib and Dlg in anterior-posterior patterning of the follicular epithelium during Drosophila oogenesis

Background Proper patterning of the follicle cell epithelium over the egg chamber is essential for the Drosophila egg development. Differentiation of the epithelium into several distinct cell types along the anterior-posterior axis requires coordinated activities of multiple signaling pathways. Previously, we reported that lethal(2)giant larvae (lgl), a Drosophila tumor...

Brain Apolipoprotein E: an Important Regulator of Food Intake in Rats

Ling Shen Patrick Tso Stephen C. Woods Deborah J. Clegg Kyna L. Barber Katherine Carey Min Liu OBJECTIVE-The worldwide prevalence of obesity is increasing at an alarming rate, along with the