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HbA1c Cutoff Point of 5.9% Better Identifies High Risk of Progression to Diabetes among Chinese Adults: Results from a Retrospective Cohort Study

Lingshu Wang,1,2,3 Tianyi He,1,2,3 Xiuping Zhang,4 Chengqiao Li,5 Weifang Yang,6 Zeqiang Ma,7 Aixia Ma,1,2,3 Xinguo Hou,1,2,3 and Li Chen1,2,3 1Department of Endocrinology, Qilu Hospital of Shandong

Stability and Hopf bifurcation for a ratio-dependent predator-prey system with stage structure and time delay

A ratio-dependent predator-prey system with time delay due to the gestation of the predator and stage structure for both the predator and the prey is investigated. By analyzing the corresponding characteristic equations, the local stability of the predator-extinction equilibrium and the coexistence equilibrium of the system are discussed, respectively. Further, the existence of...

Mesenchymal stromal cells ameliorate oxidative stress-induced islet endothelium apoptosis and functional impairment via Wnt4-β-catenin signaling

Background Islet dysfunction and destruction are the common cause for both type 1 and type 2 diabetes mellitus (T2DM). The islets of Langerhans are highly vascularized miniorgans, and preserving the structural integrity and full function of the microvascular endothelium is vital for protecting the islets from the infiltration of immune cells and secondary inflammatory attack...

Stability and Bifurcation Analysis on an Ecoepidemiological Model with Stage Structure and Time Delay

; Published 12 August 2014 Academic Editor: Sanling Yuan Copyright © 2014 Lingshu Wang and Guanghui Feng. This is an open access article distributed under the Creative Commons Attribution License, which

The Mechanism of Proinflammatory HDL Generation in Sickle Cell Disease Is Linked to Cell-Free Hemoglobin via Haptoglobin

In sickle cell disease (SCD), the inflammatory properties of high-density lipoprotein (HDL) can be changed by cell-free hemoglobin (Hb), which is released into the blood during hemolysis. Hb in the plasma of SCD patients or mice can bind with HDL specifically inducing an inflammatory reaction. In our study, we found increased amounts of inflammatory factor proteins in the chronic...

Global Stability and Hopf Bifurcation of a Predator-Prey Model with Time Delay and Stage Structure

; Published 25 February 2014 Academic Editor: Keshlan S. Govinder Copyright © 2014 Lingshu Wang and Guanghui Feng. This is an open access article distributed under the Creative Commons Attribution License

Circulating Levels of Betatrophin and Irisin Are Not Associated with Pancreatic β-Cell Function in Previously Diagnosed Type 2 Diabetes Mellitus Patients

, Shandong 250012, China Received 13 February 2015; Accepted 24 April 2015 Academic Editor: Sihem Boudina Copyright © 2016 Lingshu Wang et al. This is an open access article distributed under the Creative ... is no conflict of interests regarding the publication of this paper. Authors’ Contribution Lingshu Wang and Jun Song contributed equally to this work. Acknowledgments This study was supported by grants

C-Peptide Is Independently Associated with an Increased Risk of Coronary Artery Disease in T2DM Subjects: A Cross-Sectional Study

Objective C-peptide has been reported to be a marker of subclinical atherosclerosis in type 2 diabetes mellitus (T2DM) patients, whereas its role in coronary artery disease (CAD) has not been clarified, especially in diabetics with differing body mass indices (BMIs). Design and Methods This cross-sectional study included 501 patients with T2DM. First, all subjects were divided...

Relationship of Hemoglobin A1c with β Cell Function and Insulin Resistance in Newly Diagnosed and Drug Naive Type 2 Diabetes Patients

Sun,1 Zeqiang Ma,2 Weifang Yang,3 Chengqiao Li,4 Xiuping Zhang,5 Peng Lin,1 Lei Gong,1 Meijian Wang,1 Fuqiang Liu,1 Wenjuan Li,1 Fei Yan,1 Jun Qin,1 Lingshu Wang,1 Jidong Liu,1 Ruxing Zhao,1 Shihong

Fluctuation between Fasting and 2-H Postload Glucose State Is Associated with Chronic Kidney Disease in Previously Diagnosed Type 2 Diabetes Patients with HbA1c ≥ 7%

Objective To investigate how the glucose variability between fasting and a 2-h postload glucose state (2-h postload plasma glucose [2hPG]-fasting plasma glucose [FPG]) is associated with chronic kidney disease (CKD) in middle-aged and elderly Chinese patients previously diagnosed with type 2 diabetes. Design and Methods This cross-sectional study included 1054 previously...

Fluctuation between Fasting and 2-H Postload Glucose State Is Associated with Glomerular Hyperfiltration in Newly Diagnosed Diabetes Patients with HbA1c < 7%

Objective To investigate whether fluctuations between the fasting and 2-h postload glucose ([2-hPBG]-fasting blood glucose [FBG]) states are associated with glomerular hyperfiltration (GHF) in middle-aged and elderly Chinese patients with newly diagnosed diabetes. Design and Methods In this study, we included 679 newly diagnosed diabetes patients who were ≥40 years old. All the...

Decreased Pre-existing Ad5 Capsid and Ad35 Neutralizing Antibodies Increase HIV-1 Infection Risk in the Step Trial Independent of Vaccination

Background The Step trial raised the possibility that uncircumcised men with pre-existing Ad5 neutralizing antibodies carried an increased risk of HIV infection after vaccination. Thus, understanding Ad seropositivity in humans is important to the development of an AIDS vaccine. Here, we analyze the impact of different Ad5-specific neutralizing antibodies on immune function and...

Triglyceride Levels Are Closely Associated with Mild Declines in Estimated Glomerular Filtration Rates in Middle-Aged and Elderly Chinese with Normal Serum Lipid Levels

Objective To investigate the relationship between lipid profiles [including total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C)] and a mild decline in the estimated glomerular filtration rate (eGFR) in subjects with normal serum lipid levels. Design and Methods In this study, we included 2647...