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TEMs but not DKK1 could serve as complementary biomarkers for AFP in diagnosing AFP-negative hepatocellular carcinoma

study. Author Contributions Data curation: Yueguo Wang. Formal analysis: Yueguo Wang. Funding acquisition: Liping Mao. Investigation: Delin Wang, Gang Han. Methodology: Liping Mao. Project ... administration: Liping Mao, Yueguo Wang. Resources: Shouzhong Fu, Jianxin Wang. Software: Delin Wang, Gang Han. Validation: Shouzhong Fu, Jianxin Wang. Writing ± original draft: Liping Mao. Writing ± review

The crosstalk between autophagic and endo-/exosomal pathways in antigen processing for MHC presentation in anticancer T cell immune responses

T cells recognize antigen fragments from proteolytic products that are presented to them in the form of peptides on major histocompatibility complex (MHC) molecules, which is crucial for the T cell to identify infected or transformed cells. Autophagy, a process that delivers cytoplasmic constituents for lysosomal degradation, has been observed to provide a substantial source of...