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Erratum zu: Immuntherapie des multiplen Myeloms

Cuny C et al. MRE bei Mensch und Tier: Übertragungswege und Infekti- onsrisiko. Hyg Med. 0 Dr. med. Hans-Martin Wenchel 1 Der Übersichtsartikel von Katja Weisel und Lothar Kanz mit dem Titel ... multiple myeloma“ von Leo Rasche , Niels Weinhold, Gareth J. Morgan , Frits van Rhee und Faith E. Davies [Rasche L et al. Cancer Treat Rev. 2017;55:190-9] 2 Katja Weisel , Lothar Kanz 3 Arzt für Hygiene und

Dronabinol has preferential antileukemic activity in acute lymphoblastic and myeloid leukemia with lymphoid differentiation patterns

conflicts. Figen Akmut no conflicts. Barbara Illing no conflicts. Lothar Kanz no conflicts. Helmut Salih no conflicts. Marcus Schittenhelm no conflicts. Authors’ contributions KKS designed the research study

Choroidal metastases from thymic carcinoma during pregnancy: Case Report

Background Rare sites of metastases, atypical symptoms and paraneoplastic syndromes are often neglected or misinterpreted, especially when they represent early symptoms of an underlying malignant disease. Hence, an interdisciplinary approach to these patients is essential to avoid tumor progression and metastatic spread in order to provide curative treatment options to the...

Paraneoplastic granulocyte colony-stimulating factor secretion in soft tissue sarcoma mimicking myeloproliferative neoplasia: a case report

Background While paraneoplastic leukocytosis is a common phenomenon in solid tumors, extreme elevations of white blood counts (WBC) in the range of more than 100,000/μl are uncommon in patients with non-hematologic malignancies. Leukocytosis with mature neutrophils due to a granulocyte colony-stimulating factor (G-CSF) producing tumor is only seen on rare occasions. Case...

Severe paraneoplastic hypereosinophilia in metastatic renal cell carcinoma

Background Renal cell carcinoma can cause various paraneoplastic syndromes including metabolic and hematologic disturbances. Paraneoplastic hypereosinophilia has been reported in a variety of hematologic and solid tumors. We present the first case in the literature of severe paraneoplastic hypereosinophilia in a patient with renal cell carcinoma. Case presentation A 46 year-old...

Younger patients with chronic myeloid leukemia do well in spite of poor prognostic indicators: results from the randomized CML study IV

Since the advent of tyrosine kinase inhibitors, the impact of age on outcome of chronic myeloid leukemia (CML) patients has changed. We therefore analyzed patients from the randomized CML study IV to investigate disease manifestations and outcome in different age groups. One thousand five hundred twenty-four patients with BCR-ABL-positive chronic phase CML were divided into four...

Expression of the embryonic stem cell marker SOX2 in early-stage breast carcinoma

Background The SRY-related HMG-box family of transcription factors member SOX2 has been mainly studied in embryonic stem cells as well as early foregut and neural development. More recently, SOX2 was shown to participate in reprogramming of adult somatic cells to a pluripotent stem cell state and implicated in tumorigenesis in various organs. In breast cancer, SOX2 expression was...

Early Detection of Aspergillus Infection after Allogeneic Stem Cell Transplantation by Polymerase Chain Reaction Screening

Invasive aspergillosis (IA) has become a major cause of mortality in patients after allogeneic stem cell transplantation. To assess the potential of prospective polymerase chain reaction (PCR) screening for early diagnosis of IA, 84 recipients of an allogeneic stem cell transplant were analyzed with the investigators blinded to clinical and microbiologic data. Of 1193 blood...

Hematologic Disorders Associated With Primary Mediastinal Nonseminomatous Germ Cell Tumors

BACKGROUND. The association between primary germ cell tumors of the mediastinum (the space between the lung pleura that contains the heart and other chest viscera) and hematologic malignancies has been described by retrospective analysis of patients treated at individual clinical centers. To better characterize the risk of hematologic disorders in patients with extragonadal germ...

Incidence of Metachronous Testicular Cancer in Patients With Extragonadal Germ Cell Tumors

Background: The frequency of subsequent testicular cancer (referred to as metachronous testicular cancer) in men who have had previous testicular cancer is relatively high. The rate of metachronous testicular cancer in men with extragonadal germ cell tumors (EGCTs), however, is largely unknown. We conducted a retrospective study of EGCT patients to determine the incidence...