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Impact of the Adalimumab Patient Support Program on Clinical Outcomes in Ankylosing Spondylitis: Results from the COMPANION Study

. Disclosures. Louis Bessette has served as a speaker for AbbVie, Amgen, BMS, Janssen, Roche, UCB, Pfizer, Merck, Celgene, Lilly, and Novartis and as a consultant for AbbVie, Amgen, BMS, Janssen, Roche, UCB

Single-Arm Study of Etanercept in Adult Patients with Moderate to Severe Rheumatoid Arthritis Who Failed Adalimumab Treatment

of Amgen Inc.) assisted with the preparation and submission of the manuscript. Disclosures. Louis Bessette: Amgen, AbbVie, Pfizer, UCB, Janssen, Bristol-Myers Squibb, and Roche consultancies, speaking

Chondroitin sulfate efficacy versus celecoxib on knee osteoarthritis structural changes using magnetic resonance imaging: a 2-year multicentre exploratory study

Background In osteoarthritis (OA) treatment, although chondroitin sulfate (CS) was found in a number of studies using radiography to have a structure-modifying effect, to date CS use is still under debate. A clinical study using quantitative magnetic resonance imaging (qMRI) is therefore of the utmost importance. Here we report data from a 24-month, randomised, double-blind...

Loss of health related quality of life following low-trauma fractures in the elderly

Background To estimate the long-term change in health related quality of life (HRQoL) following low-trauma fractures among individuals receiving home care (HC) services or living in long-term care (LTC) facilities using linked healthcare administrative data from Ontario, Canada. Methods HRQoL was estimated using the Health Utility Index (HUI-2) with the InterRai Minimum Data Set...

The presence of meniscal lesions is a strong predictor of neuropathic pain in symptomatic knee osteoarthritis: a cross-sectional pilot study

Introduction Pain in osteoarthritis (OA) has been classically attributed to joint structural damage. Disparity between the degree of radiographic structural damage and the severity of symptoms implies that factors other than the joint pathology itself contribute to the pain. Peripheral and central sensitization have been suggested as two of the underlying mechanisms that...

Early medication use in new-onset rheumatoid arthritis may delay joint replacement: results of a large population-based study

Introduction Use of disease-modifying anti-rheumatic drugs (DMARDs) in rheumatoid arthritis (RA) may prevent joint damage and potentially reduce joint replacement surgeries. We assessed the association between RA drug use and joint replacement in Quebec, Canada. Methods A cohort of new-onset RA patients was identified from Quebec’s physician billing and hospitalization databases...

Rheumatoid arthritis prevalence in Quebec

Background To estimate rheumatoid arthritis (RA) prevalence in Quebec using administrative health data, comparing across regions. Methods Cases of RA were ascertained from physician billing and hospitalization data, 1992–2008. We used three case definitions: 1) ≥ 2 billing diagnoses, submitted by any physician, ≥ 2 months apart, but within 2 years; 2) ≥ 1 diagnosis, by a...