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Satisfaction and convenience of using terpenoid-impregnated eyelid wipes and teaching method in people without blepharitis

Satisfaction and convenience of using terpenoid-impregnated eyelid wipes and teaching method in people without blepharitis Tian Yu Qiu,1 Sharon Yeo,2 Louis Tong1–4 1Yong Loo Lin School of Medicine, National University of Singapore, 2Singapore Eye Research Institute, 3Singapore National Eye Centre, 4Duke-NUS Medical School, Singapore Purpose: Demodex infestations cause blepharitis...

Detection of Pathological Myopia by PAMELA with Texture-Based Features through an SVM Approach

Pathological myopia is the seventh leading cause of blindness worldwide. Current methods for the detection of pathological myopia are manual and subjective. We have developed a system known as PAMELA (Pathological Myopia Detection Through Peripapillary Atrophy) to automatically assess a retinal fundus image for pathological myopia. This paper focuses on the texture analysis...

Toll-like receptor 2-mediated NF-kappa B pathway activation in ocular surface epithelial cells

Background Gram-positive bacteria stimulate Toll-like receptor (TLR) 2 and then activate the pro-inflammatory nuclear factor-kappa B (NF-κB) pathway. As the human ocular surface is heavily colonised by gram-positive cocci bacteria, a balance of activation/repression of NF-κB target genes is essential to avoid uncontrolled infection or autoimmune-related inflammation. It is...

Review of autoantigens in Sjögren’s syndrome: an update

Review of autoantigens in Sjogren's syndrome: an update Louis Tong,1–4 Vanessa Koh,3 Bernard Yu-Hor Thong5 1Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of

Systematic review of randomized controlled trials in the treatment of dry eye disease in Sjogren syndrome

allowing this multi-disciplinary collaboration to be possible. Availability of data and material Not applicable. Authors’ contribution Dr. Kendrick Co Shih, Dr. Christie Lun and Dr. Louis Tong were

Systematic review of randomized controlled trials in the treatment of dry eye disease in Sjogren syndrome

allowing this multi-disciplinary collaboration to be possible. Availability of data and material Not applicable. Authors’ contribution Dr. Kendrick Co Shih, Dr. Christie Lun and Dr. Louis Tong were

Systematic review of randomized controlled trials in the treatment of dry eye disease in Sjogren syndrome

of data and material Not applicable. Authors’ contribution Dr. Kendrick Co Shih, Dr. Christie Lun and Dr. Louis Tong were responsible for study design/planning, data collection, data analysis and

The effect of intravitreal injections on dry eye, and proposed management strategies

The effect of intravitreal injections on dry eye, and proposed management strategies Augustinus Laude,1–3 Jimmy WK Lim,1,2 Vishwanath Srinagesh,4 Louis Tong2,5–7 1National Healthcare Group Eye Institute, Tan Tock Seng Hospital, 2Singapore Eye Research Institute, 3Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; 4Krieger Eye Institute, Baltimore, MD...

Systematic review of randomized controlled trials in the treatment of dry eye disease in Sjogren syndrome

’ contribution Dr. Kendrick Co Shih, Dr. Christie Lun and Dr. Louis Tong were responsible for study design/planning, data collection, data analysis and writing up the manuscript. Dr. Bernard Thong and Prof

Systematic review of randomized controlled trials in the treatment of dry eye disease in Sjogren syndrome

allowing this multi-disciplinary collaboration to be possible. Availability of data and material Not applicable. Authors’ contribution Dr. Kendrick Co Shih, Dr. Christie Lun and Dr. Louis Tong were

Need for Animal Models of Meibomian Gland Dysfunction

Evaporative dry eye has gained increasing interest in recent years in academia, pharmaceutical, and medical device industries. The main cause of this type of dry eye is attributed to meibomian gland dysfunction (MGD). MGD is a diffuse abnormality of the meibomian glands characterised by terminal duct obstruction and eventually leading to signs and symptoms of dry eye. There have...

Ocular lubricant use in medically and surgically treated glaucoma: a retrospective longitudinal analysis

Ocular lubricant use in medically and surgically treated glaucoma: a retrospective longitudinal analysis Jayant Venkatramani Iyer,1–3 Yang Zhao,3 Fiona Pin Miao Lim,1,2 Louis Tong,1–4 Tina Tzee Ling

Agreement of non-invasive tear break up time measurement between Tomey RT-7000 Auto Refractor-Keratometer and Oculus Keratograph 5M

tear break-up time; tear film; Oculus Keratograph; Tomey RT-7000; dry eye - open access to scientific and medical research O r i g i n a l r e s e a r C h ryan lee 1,2 sharon Yeo 1 han Tun aung 3 louis ... Tong 1,2,4,5 1Ocular surface research group, singapore eye research institute, 2Yong loo lin school of Medicine, n ational University of singapore, 3s chool of h ealth s ciences, n gee ann Polytechnic

Intra-observer and inter-observer repeatability of ocular surface interferometer in measuring lipid layer thickness

. Acknowledgements Louis Tong was supported by the National Medical Research Council, Singapore (NMRC/CSA/045/2012) and the Biomedical Research Council, Singapore (BMRC (TCRP) 10/1/35/19/670 R828). Grant support This

Practical issues concerning tear protein assays in dry eye

Dry eye is a common clinical condition diagnosed by cumulative evidence of symptoms and signs. Many new treatments in dry eye are either expensive, invasive, have potential for side effects, or are not easily accessible. In severe dry eye, the ideal modality of treatment to begin with is often not clear as specific molecular disturbances are not evident from just examination of...

Ocular surface disease in posttrabeculectomy/mitomycin C patients

Ocular surface disease in posttrabeculectomy/mitomycin C patients Janice Lam,1,2 Tina T Wong,1–4 Louis Tong1–3,5 1Singapore National Eye Centre, Singapore; 2Singapore Eye Research Institute, Singapore; 3Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; 4School of Materials Science and Engineering, Nanyang Technological...

Knowledge, Attitude, and Practice of Dry Eye Treatment by Institutional Chinese Physicians in Singapore

Dry eye is a common health problem worldwide, causing significant discomfort and inconvenience to sufferers. The conventional treatment of dry eye via topical administration of eye drops is deemed palliative and unsatisfactory to many. Traditional Chinese medicine (TCM) has shown some promise in dry eye treatment; however, the extent of its use and acceptance is uncertain. We...

Evaluation of Global Differential Gene and Protein Expression in Primary Pterygium: S100A8 and S100A9 as Possible Drivers of a Signaling Network

Purpose Pterygium is a wing shaped fibrovascular growth on the ocular surface, characterized by fibrosis, angiogenesis, extracellular matrix remodeling, and inflammatory infiltrates. Epidemiologic studies have linked pterygium formation to various chronic inflammatory conditions, such as ultraviolet radiation, sawdust exposure, and dry eye disease. The purpose of this study is to...

Rho GTPases and Regulation of Cell Migration and Polarization in Human Corneal Epithelial Cells

PurposeEpithelial cell migration is required for regeneration of tissues and can be defective in a number of ocular surface diseases. This study aimed to determine the expression pattern of Rho family small G-proteins in human corneal epithelial cells to test their requirement in directional cell migration. MethodsRho family small G-protein expression was assessed by reverse...

A Randomized, Controlled Treatment Trial of Eyelid-Warming Therapies in Meibomian Gland Dysfunction

Aim The main treatment for meibomian gland dysfunction (MGD), a major cause of dry eye, is eyelid warming. Lack of compliance is the main reason for treatment failure. This has led to the development of eyelid-warming devices that are safe, effective and convenient. To obtain robust evidence demonstrating their efficacy, the authors conducted a 3-arm randomized clinical study...