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New cosmological constraints with extended-Baryon Oscillation Spectroscopic Survey DR14 quasar sample

We update the constraints on the cosmological parameters by adopting the Planck data released in 2015 and baryon acoustic oscillation (BAO) measurements including the new DR14 quasar sample measurement at redshift \(z=1.52\), and we conclude that the six-parameter \(\Lambda \)CDM model is preferred. Exploring some extensions to the \(\Lambda \)CDM model, we find that the equation ...

Comparison of laser and circumlimbal suture induced elevation of intraocular pressure in albino CD-1 mice

. (TIF) Acknowledgments The authors thank Izhar Livne-Bar and Paul Cullen for assistance in OCT and histological analysis. Author Contributions Conceptualization: Hsin-Hua Liu, Lu Chen, John G ... . Flanagan. Data curation: Hsin-Hua Liu, Liwei Zhang, Meng Shi. Formal analysis: Hsin-Hua Liu, Liwei Zhang, Meng Shi. Funding acquisition: Hsin-Hua Liu, Lu Chen, John G. Flanagan. Investigation: Hsin-Hua

Effect of inspiratory synchronization during pressure-controlled ventilation on lung distension and inspiratory effort

Background In pressure-controlled (PC) ventilation, tidal volume (V T) and transpulmonary pressure (P L ) result from the addition of ventilator pressure and the patient’s inspiratory effort. PC modes can be classified into fully, partially, and non-synchronized modes, and the degree of synchronization may result in different V T and P L despite identical ventilator settings. This ...

DCTN1 gene analysis in Chinese patients with sporadic amyotrophic lateral sclerosis

their participation. Author Contributions Conceptualization: Dongsheng Fan. Data curation: Lu Chen, Xiaolu Liu. Investigation: Xiangyi Liu, Lipeng Yang. Methodology: Xiangyi Liu, Lipeng Yang ... . Project administration: Lu Tang. Resources: Lu Chen. Supervision: Dongsheng Fan. Validation: Lu Tang, Dongsheng Fan. Visualization: Xiaolu Liu. Writing ± original draft: Xiangyi Liu, Lipeng Yang

Evaluating somatic tumor mutation detection without matched normal samples

Observations of recurrent somatic mutations in tumors have led to identification and definition of signaling and other pathways that are important for cancer progression and therapeutic targeting. As tumor cells contain both an individual’s inherited genetic variants and somatic mutations, challenges arise in distinguishing these events in massively parallel sequencing datasets. ...

Exosomes derived from human menstrual blood-derived stem cells alleviate fulminant hepatic failure

Background Human menstrual blood-derived stem cells (MenSCs) are a novel source of MSCs that provide the advantage of being easy to collect and isolate. Exosomes contain some mRNAs and adhesion molecules that can potentially impact cellular and animal physiology. This study aimed to investigate the therapeutic potential of MenSC-derived exosomes (MenSC-Ex) on AML12 cells (in vitro) ...

Whole-exome sequencing in amyotrophic lateral sclerosis suggests NEK1 is a risk gene in Chinese

Background Amyotrophic lateral sclerosis (ALS) is a progressive neurological disease characterised by the degeneration of motor neurons, which are responsible for voluntary movement. There remains limited understanding of disease aetiology, with median survival of ALS of three years and no effective treatment. Identifying genes that contribute to ALS susceptibility is an important ...

Illumina-based transcriptomic profiling of Panax notoginseng in response to arsenic stress

Background Panax notoginseng, a famous herbal medicine, has recently attracted great attention on its safety and quality since P. notoginseng can accumulate and tolerate As from growing environment. For the purpose of understanding As damage to the quality of P. notoginseng as well as corresponding tolerance mechanisms, genes involved in As stress response were identified using ...

The role of expression imbalance between adipose synthesis and storage mediated by PPAR-γ/FSP27 in the formation of insulin resistance in catch up growth

Background Catch up growth (CUG) motivated by under-nutrition can lead to insulin resistance (IR) and visceral fat over-accumulation. However, the precise mechanisms on IR induced by adipose tissue changes during CUG remain unresolved. Methods Experimental rats were divided into three groups: normal chow group, catch up growth group and resveratrol administrated group. The whole ...

Prevention of Evisceration or Enucleation in Endogenous Bacterial Panophthalmitis with No Light Perception and Scleral Abscess

Panophthalmitis is the most extensive ocular involvement in endophthalmitis with inflammation in periocular tissues. Severe inflammation of the anterior and posterior segments is frequently accompanied by corneal opacity, scleral abscess, and perforation or rupture. Enucleation or evisceration was the only remaining viable treatment option when all options to salvage the eye had ...

Effect of Metformin Use on Survival in Resectable Pancreatic Cancer: A Single-Institution Experience and Review of the Literature

Observational studies have demonstrated that metformin use in diabetic patients is associated with reduced cancer incidence and mortality. Here, we aimed to determine whether metformin use was associated with improved survival in patients with resected pancreatic cancer. All patients with diabetes who underwent resection for pancreatic adenocarcinoma between 12/1/1986 and 4/30/2013 ...

Is Cesarean Delivery Preferable in Twin Pregnancies at >=36 Weeks Gestation?

Background The optimal mode of delivery in twin pregnancies remains controversial. A recent randomized trial did not find any benefit of planned cesarean vs. vaginal delivery at 32–38 weeks gestation, but the trial was not powered to detect a moderate effect. We aimed to evaluate the impact of cesarean delivery on perinatal mortality and severe neonatal morbidity in twin ...

Income-related children�s health inequality and health achievement in China

finalized the manuscript. All authors read and approved the final manuscript. Authors information Lu Chen, PhD Lu Chen is Associate Professor in the School of Economics, Nankai University. Her research

Genome-wide analysis of differential transcriptional and epigenetic variability across human immune cell types

Background A healthy immune system requires immune cells that adapt rapidly to environmental challenges. This phenotypic plasticity can be mediated by transcriptional and epigenetic variability. Results We apply a novel analytical approach to measure and compare transcriptional and epigenetic variability genome-wide across CD14 + CD16 − monocytes, CD66b + CD16 + neutrophils, and ...

A Biomechanical Comparison of Expansive Pedicle Screws for Severe Osteoporosis: The Effects of Screw Design and Cement Augmentation

Expansive pedicle screws significantly improve fixation strength in osteoporotic spines. However, the previous literature does not adequately address the effects of the number of lengthwise slits and the extent of screw expansion on the strength of the bone/screw interface when expansive screws are used with or without cement augmentation. Herein, four designs for expansive pedicle ...

Prevalence and factors associated with occupational burnout among HIV/AIDS healthcare workers in China: a cross-sectional study

Background Burnout is a psychosomatic syndrome characterized by three dimensions (emotional exhaustion [EE], feelings of depersonalization [DP], and reduced personal accomplishment [PA]). We determined the prevalence of burnout and mental health status between HIV/AIDS healthcare workers and other healthcare workers, and determined the factors associated with burnout of HIV/AIDS ...

Arthralgia among women taking aromatase inhibitors: is there a shared inflammatory mechanism with co-morbid fatigue and insomnia?

Introduction Arthralgia is a common toxicity among women taking aromatase inhibitors (AIs) and can lead to premature discontinuation of therapy. We evaluated the association between arthralgia, co-morbid fatigue and/or insomnia, and inflammatory biomarkers among women taking AIs. Methods Women taking AIs for early-stage breast cancer completed a modified version of the Brief Pain ...

Disparities and Trends in Birth Outcomes, Perinatal and Infant Mortality in Aboriginal vs. Non-Aboriginal Populations: A Population-Based Study in Quebec, Canada 1996–2010

Background Aboriginal populations are at substantially higher risks of adverse birth outcomes, perinatal and infant mortality than their non-Aboriginal counterparts even in developed countries including Australia, U.S. and Canada. There is a lack of data on recent trends in Canada. Methods We conducted a population-based retrospective cohort study (n = 254,410) using the linked ...

Trim28 Contributes to EMT via Regulation of E-Cadherin and N-Cadherin in Lung Cancer Cell Lines

In previous work, we demonstrated that transcription factor Trim28 (Tripartite motif containing 28) plays a tumor-suppressor role in early-staged adenocarcinoma of the lung due to its ability to restrain transcription of cell cycle-regulating genes. Herein we examine Trim28's role in the epithelial-to-mesenchymal transition (EMT) which is strongly implicated in cancer metastasis. ...