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Probing the Structural, Electronic, and Magnetic Properties of Ag n V (n = 1–12) Clusters

The structural, electronic, and magnetic properties of Ag n V (n = 1–12) clusters have been studied using density functional theory and CALYPSO structure searching method. Geometry optimizations manifest that a vanadium atom in low-energy AgnV clusters favors the most highly coordinated location. The substitution of one V atom for an Ag atom in Ag n + 1 (n ≥ 5) cluster modifies...

Metal-based proteasomal deubiquitinase inhibitors as potential anticancer agents

Deubiquitinases (DUBs) play an important role in protein quality control in eukaryotic cells due to their ability to specifically remove ubiquitin from substrate proteins. Therefore, recent findings have focused on the relevance of DUBs to cancer development, and pharmacological intervention on these enzymes has become a promising strategy for cancer therapy. In particular...

Fine Mapping and Whole-Genome Resequencing Identify the Seed Coat Color Gene in Brassica rapa

A yellow seed coat is a desirable agronomic trait in the seeds of oilseed-type Brassica crops. In this study, we identified a candidate gene for seed coat color in Dahuang, a landrace of Brassica rapa. A previous study of Dahuang mapped the seed coat color gene Brsc1 to a 2.8-Mb interval on chromosome A9 of B. rapa. In the present study, the density of the linkage map for Brsc1...

Existence of Multiple Positive Solutions for Choquard Equation with Perturbation

This paper is concerned with the following Choquard equation with perturbation: , , where , , and . This kind of equations is well known as the Choquard or nonlinear Schrödinger-Newton equation. Under some assumptions for the functions , we prove the existence of multiple positive solutions of the equation. Moreover, we also show that these results still hold for more generalized...

LINE-1 in cancer: multifaceted functions and potential clinical implications

University, Huai’an, Jiangsu, ChinaMa Shi-Jie AuthorsSearch for Lu Xiao-Jie in:Nature Research journals • PubMed • Google ScholarSearch for Xue Hui-Ying in:Nature Research journals • PubMed • Google

LKB1/AMPK inhibits TGF-β1 production and the TGF-β signaling pathway in breast cancer cells

Adenosine monophosphate-activated protein kinase (AMPK) acts as a fuel gauge that maintains energy homeostasis in both normal and cancerous cells, and has emerged as a tumor suppressor. The present study aims to delineate the functional relationship between AMPK and transforming growth factor beta (TGF-β). Our results showed that expression of liver kinase B1 (LKB1), an upstream...

The Expression of EPOR in Renal Cortex during Postnatal Development

Erythropoietin (EPO), known for its role in erythroid differentiation, has been shown to be an important growth factor for brain and heart. EPO is synthesized by fibroblast-like cells in the renal cortex. Prompted by this anatomical relationship and its significant impact on the maturation process of brain and heart, we asked whether EPO could play a role during the development...

Improved Rao-Blackwellized Particle Filter by Particle Swarm Optimization

The Rao-Blackwellized particle filter (RBPF) algorithm usually has better performance than the traditional particle filter (PF) by utilizing conditional dependency relationships between parts of the state variables to estimate. By doing so, RBPF could not only improve the estimation precision but also reduce the overall computational complexity. However, the computational burden...