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AKI - Clinical

Introduction and Aims: Gadolinium chelate (GC)s using in magnetic resonance imaging (MRI) have been traditionally considered as non-nephrotoxic contrast materials. But, in some recent articles it has been suggested that GCs may have a nephrotoxic potential. Nevertheless, most of these reports are retrospective, and evaluated contrast agents and their doses were not homogenous. To...

Accurate whole human genome sequencing using reversible terminator chemistry

. Tzonev Eric H. Vermaas Klaudia Walter Xiaolin Wu Lu Zhang Mohammed D. Alam Carole Anastasi Ify C. Aniebo David M. D. Bailey Iain R. Bancarz Saibal Banerjee Selena G. Barbour Primo A. Baybayan Vincent A

An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge

Background There is tremendous potential for genome sequencing to improve clinical diagnosis and care once it becomes routinely accessible, but this will require formalizing research methods into clinical best practices in the areas of sequence data generation, analysis, interpretation and reporting. The CLARITY Challenge was designed to spur convergence in methods for diagnosing...

The balance of reproducibility, sensitivity, and specificity of lists of differentially expressed genes in microarray studies

• Google Scholar Search for Jie Wu in:PubMed • Google Scholar Search for Qian Xie in:PubMed • Google Scholar Search for Liang Zhang in:PubMed • Google Scholar Search for Lu Zhang in:PubMed • Google

The balance of reproducibility, sensitivity, and specificity of lists of differentially expressed genes in microarray studies

Jie Wu Qian Xie Liang Zhang Lu Zhang Sheng Zhong Russell D Wolfinger Weida Tong - * Corresponding author from Fifth Annual MCBIOS Conference. Systems Biology: Bridging the Omics Oklahoma City, OK

Genome-Wide Association Study in Asian Populations Identifies Variants in ETS1 and WDFY4 Associated with Systemic Lupus Erythematosus

Chun-Ming Wong Tsz Leung Lee Marco Hok Kung Ho Pamela Pui Wah Lee Yuk Kwan Chang Philip H. Li Ruo-Jie Li Lu Zhang Wilfred Hing Sang Wong Irene Oi Lin Ng Chak Sing Lau Pak Chung Sham Yu Lung Lau Asian

Genomic Convergence Analysis of Schizophrenia: mRNA Sequencing Reveals Altered Synaptic Vesicular Transport in Post-Mortem Cerebellum

, data collection and analysis, decision to publish, or preparation of the manuscript. Competing Interests: Irina Khrebtukova, Shujun Luo, Lu Zhang and Gary P. Schroth are employees of Illumina Inc. Wendy ... with gene expression profiling of human cerebellar tissue. Irina Khrebtukova, Shujun Luo, Lu Zhang and Gary P. Schroth are employees of Illumina Inc. Study data is available at NCBI Gene Expression

Meta-analysis of GWAS on two Chinese populations followed by replication identifies novel genetic variants on the X chromosome associated with systemic lupus erythematosus

Yan Zhang 8 Jing Zhang 8 Jing Yang 8 Yongfei Wang 8 Lu Zhang 8 Xianbo Zuo 9 Liangdan Sun 9 Hai-Feng Pan 14 Nattiya Hirankarn 13 Tingyou Wang 8 Ruoyan Chen 8 Dingge Ying 8 Shuai Zeng 8 Jiangshan Jane

Three SNPs in chromosome 11q23.3 are independently associated with systemic lupus erythematosus in Asians

Systemic lupus erythematosus (SLE) has a complex etiology and is affected by both genetic and environmental factors. Although more than 40 loci have shown robust association with SLE, the details of these loci, such as the independent contributors and the genes involved, are still unclear. In this study, we performed meta-analysis of two existing genome-wide association studies...

Meta-analysis of two Chinese populations identifies an autoimmune disease risk allele in 22q11.21 as associated with systemic lupus erythematosus

Shing Faculty of Medicine and Queen Mary Hospital, The University of Hong Kong, 21 Sassoon Road, Hong Kong, ChinaYan Zhang, Yong-Fei Wang, Jing Yang, Jing Zhang, Tsz Leung Lee, Lu Zhang, Jiangshan Jane ... Moon Ho Leung in:PubMed • Google Scholar Search for Chi Chiu Mok in:PubMed • Google Scholar Search for Lu Zhang in:PubMed • Google Scholar Search for Jiangshan Jane Shen in:PubMed • Google Scholar

Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis

Monozygotic or ‘identical’ twins have been widely studied to dissect the relative contributions of genetics and environment in human diseases. In multiple sclerosis (MS), an autoimmune demyelinating disease and common cause of neurodegeneration and disability in young adults, disease discordance in monozygotic twins has been interpreted to indicate environmental importance in its...

Status of the Eradication of Indigenous Wild Poliomyelitis in the People's Republic of China

Alarge nationwide outbreak occurred in 1989–1990 in China, in which nearly 10,000 poliomyelitis cases were reported. After two rounds of oral poliovirus vaccine (OPV) supplemental activity in nearly every province in the 1992–1993 winter season, no wild poliovirus was detected in 1993 in 22 provinces in the middle of China that contained 86% of the population. During the first...

Meta-analysis of two Chinese populations identifies an autoimmune disease risk allele in 22q11.21 as associated with systemic lupus erythematosus

Introduction Systemic lupus erythematosus (SLE) is a heterogeneous disease with a diverse spectrum of clinical symptoms, ranging from skin rash to end-organ damage. 22q11.21 has been identified as a susceptibility region for several autoimmune diseases, including SLE. However, detailed information for SLE association and the underlying functional mechanism(s) is still lacking...

Surveillance for Polio Eradication in the People's Republic of China

A case-based virus surveillance system for wild poliovirus in China was developed. By 1993, all 30 provincial immunization units and, by 1994, all 29 provincial laboratories were sending computerized data to the national level. In 1993, a county-level, computerized map was operationalized that permitted visual monitoring of the progress of the polio eradication program every...

Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma

Yang, Jie Zhao, Chuan Lin, Chen-Jie Qin, Ze-Ya Pan, Gang Huang, Hui Liu, Jin Zhang, Ruo-Yu Wang, Yun Yang, Wen Wen, Gui-Shuai Lv, Hui-Lu Zhang, Han Wu, Shuai Huang, Ming-Da Wang, Liang Tang, Ye-Xiong Tan ... , Gui-Shuai Lv, Hui-Lu Zhang, Han Wu, Ming-Da Wang, Liang Tang, Ye-Xiong Tan & Hong-Yang WangBGI-Shenzhen, Shenzhen 518083, ChinaXiao Liu, Wei-Yang Li, Xi Zeng, Shi-Ping Liu, Xue-Han Zhuang, Hong-Zhi Cao

Erratum: Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma

Xue-Han Zhuang Chuan Lin Chen-Jie Qin Yi Zhao Ze-Ya Pan Gang Huang Hui Liu Jin Zhang Ruo-Yu Wang Yun Yang Wen Wen Gui-Shuai Lv Hui-Lu Zhang Han Wu Shuai Huang Ming-Da Wang Liang Tang Hong-Zhi Cao Ling

Chronic Lymphocytic Leukemia Cells Recognize Conserved Epitopes Associated with Apoptosis and Oxidation

Lu Zhang, Steven L. Allen, Jonathan Kolitz, Kanti R. Rai, Charles C. Chu & Nicholas ChiorazziRheumatic Diseases Core Center and Laboratory of B-Cell Immunobiology, University of California, San Diego ... • Google Scholar Search for Katerina Hatzi in:PubMed • Google Scholar Search for Till Seiler in:PubMed • Google Scholar Search for Sebastien Didier in:PubMed • Google Scholar Search for Lu Zhang in:PubMed

Base-Pair Resolution DNA Methylation Sequencing Reveals Profoundly Divergent Epigenetic Landscapes in Acute Myeloid Leukemia

We have developed an enhanced form of reduced representation bisulfite sequencing with extended genomic coverage, which resulted in greater capture of DNA methylation information of regions lying outside of traditional CpG islands. Applying this method to primary human bone marrow specimens from patients with Acute Myelogeneous Leukemia (AML), we demonstrated that genetically...

Elevated levels of plasma D-dimer predict a worse outcome in patients with nasopharyngeal carcinoma

Background Hemostatic alterations occur during the development of cancer. Plasma D-dimer is a hypercoagulability and fibrinolytic system marker that is increased in patients with various solid tumours. The aim of this study was to evaluate the hemostatic status of nasopharyngeal carcinoma (NPC) patients by assessing plasma D-dimer levels to investigate its value as a prognostic...