In Saccharomyces cerevisiae mitochondrial dysfunction induces retrograde signaling, a pathway of communication from mitochondria to the nucleus that promotes a metabolic remodeling to ensure sufficient biosynthetic precursors for replication. Rtg2p is a positive modulator of this pathway that is also required for cellular longevity. This protein belongs to the ASKHA superfamily...
Leonardo Henrique Frana de Lima Lucas Bleicher Background: Nuclear receptors (NRs) are transcription factors which bind small hormones, whose evolutionary history and the presence of different functional
decomposition for ELSC, cutoff = 0.8maximum. (DOC) Acknowledgments Lucas Bleicher thanks Patrcia de Moura, Jose Fernando Ruggiero Bachega and Claudia Linhares Sales for fruitful discussions on peroxidases
Nuclear receptors (NRs) are transcription factors which bind small hormones, whose evolutionary history and the presence of different functional surfaces makes them an interesting target for a correlation based analysis. Correlation analysis of ligand binding domains shows that correlated residue subsets arise from the differences between functional sites in different nuclear...
. C. Salgado Larissa L. S. Scholte Lucas Bleicher Patr?cia S. Costa Mariana P. Reis Marcela F. Dias Marcelo P. ?vila Francisco A. R. Barbosa Edmar Chartone-Souza Andr?a M. A. Nascimento OPEN Published
As an auxiliary tool in Physics teaching, the utilization of analytical programming and multimedia facilities of the symbolic computing software Mathematica is shown. It is possible to verify the frequency ratios in a musical scale and the beat effect by mathematical analysis and audible reproduction by the computer. For illustrative and pedagogical purposes, sound effects...
Background Thyroid receptors, TRα and TRβ, are involved in important physiological functions such as metabolism, cholesterol level and heart activities. Whereas metabolism increase and cholesterol level lowering could be achieved by TRβ isoform activation, TRα activation affects heart rates. Therefore, β-selective thyromimetics have been developed as promising drug-candidates for...
Thyroid receptors, TRα and TRβ, are involved in important physiological functions such as metabolism, cholesterol level and heart activities. Whereas metabolism increase and cholesterol level lowering could be achieved by TRβ isoform activation, TRα activation affects heart rates. Therefore, β-selective thyromimetics have been developed as promising drug-candidates for treatment...