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14 papers found.
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Serum magnesium and risk of incident heart failure in older men: The British Regional Heart Study

To examine the association between serum magnesium and incident heart failure (HF) in older men and investigate potential pathways including cardiac function, inflammation and lung function. Prospective study of 3523 men aged 60–79 years with no prevalent HF or myocardial infarction followed up for a mean period of 15 years, during which 268 incident HF cases were ascertained...

Copeptin and the risk of incident stroke, CHD and cardiovascular mortality in older men with and without diabetes: The British Regional Heart Study

Aims/hypothesis This study aimed to examine the association between copeptin (a surrogate marker of arginine vasopressin) and incident stroke, CHD and cardiovascular mortality in older men with and without diabetes. Methods We conducted a prospective study of 3536 men aged 60–79 years who were followed for an average of 13 years. During this period, there were 437 major CHD...

Validity of questionnaire-based assessment of sedentary behaviour and physical activity in a population-based cohort of older men; comparisons with objectively measured physical activity data

Background Older adults are the most inactive age group and self-reporting of activities may be complicated by age-related reductions in structured activities and misclassification or recall biases. We investigate the validity of simple questionnaires about sedentary behaviour (SB), (including the widely used proxy television (TV) viewing), and physical activity (PA) in...

The relationships between body composition characteristics and cognitive functioning in a population-based sample of older British men

Background Current research has established obesity as one of the main modifiable risk factors for cognitive impairment. However, evidence on the relationships of total and regional body composition measures as well as sarcopenia with cognitive functioning in the older population remains inconsistent. Methods Data are based on 1,570 participants from the British Regional Heart...

Does duration of physical activity bouts matter for adiposity and metabolic syndrome? A cross-sectional study of older British men

Background Older adults have low physical activity(PA) and high sedentary behaviour(SB) levels. We investigate how total volume and specific patterns of moderate to vigorous PA(MVPA), light PA(LPA) and SB are related to adiposity and metabolic syndrome (MS). Then, with reference to physical activity guidelines which encourage MVPA in bouts > =10 min and avoiding “long” sedentary...

Diurnal patterns of objectively measured physical activity and sedentary behaviour in older men

Background Physical activity (PA) levels among older adults are generally low and sedentary behaviour (SB) very common; increasing PA and reducing SB levels could have appreciable health benefits. Quantifying PA and SB patterns through the day could help in defining strategies for change. We examined within day variations in PA and SB and whether these varied by demographic...

Adiposity in Early, Middle and Later Adult Life and Cardiometabolic Risk Markers in Later Life; Findings from the British Regional Heart Study

Objectives: This research investigates the associations between body mass index (BMI) at 21, 40–59, 60–79 years of age on cardiometabolic risk markers at 60–79 years. Methods: A prospective study of 3464 British men with BMI measured at 40–59 and 60–79 years, when cardiometabolic risk was assessed. BMI at 21 years was ascertained from military records, or recalled from middle-age...

Longitudinal Associations Between Changes in Physical Activity and Onset of Type 2 Diabetes in Older British Men: The influence of adiposity

BARBARA J. JEFFERIS MSC PHD PETER H. WHINCUP PHD FFPH LUCY LENNON MSC S. GOYA WANNAMETHEE PHD FFPH E p i d e m i o l o g y / H e a l t h OBJECTIVEdTo determine how much physical activity (PA) is

Carboxyhaemoglobin levels and their determinants in older British men

Background Although there has been concern about the levels of carbon monoxide exposure, particularly among older people, little is known about COHb levels and their determinants in the general population. We examined these issues in a study of older British men. Methods Cross-sectional study of 4252 men aged 60–79 years selected from one socially representative general practice...

Is Socioeconomic Position Related to the Prevalence of Metabolic Syndrome?: Influence of social class across the life course in a population-based study of older men

SHEENA E. RAMSAY PETER H. WHINCUP RICHARD MORRIS PHD LUCY LENNON MSC S.G. WANNAMETHEE PHD C a r d i o v a s c u l a r a n d Influence of social class across the life course in a population-based

Tissue Plasminogen Activator, von Willebrand Factor, and Risk of Type 2 Diabetes in Older Men

S. GOYA WANNAMETHEE PHD NAVEED SATTAR ANN RUMLEY PHD PETER H. WHINCUP LUCY LENNON MSC GORDON D.O. LOWE DSC C a r d i o v a s c u l a r a n d OBJECTIVE - The objective of this study was to assess the

Missed opportunities for secondary prevention of cerebrovascular disease in elderly British men from 1999 to 2005: a population-based study

Objective We examined patterns in medication use for secondary prevention of cerebrovascular disease in older British men from 1999 to 2005, and investigated socio-demographic and disease-related influences on medication use. Methods Percentage use of antiplatelet drugs, blood pressure-lowering drugs and statins use was calculated in men, aged 65–87 years in 2005, who had been...

Hepatic Enzymes, the Metabolic Syndrome, and the Risk of Type 2 Diabetes in Older Men

OBJECTIVE—We have examined the relationship between hepatic enzymes, the metabolic syndrome, insulin resistance, and type 2 diabetes and assessed the potential of hepatic enzyme measurements in determining diabetes risk. RESEARCH DESIGN AND METHODS—We conducted a prospective study of 3,500 nondiabetic men aged 60–79 years who were followed-up for a mean period of 5 years and in...

Long-Term Interleukin-6 Levels and Subsequent Risk of Coronary Heart Disease: Two New Prospective Studies and a Systematic Review

Background The relevance to coronary heart disease (CHD) of cytokines that govern inflammatory cascades, such as interleukin-6 (IL-6), may be underestimated because such mediators are short acting and prone to fluctuations. We evaluated associations of long-term circulating IL-6 levels with CHD risk (defined as nonfatal myocardial infarction [MI] or fatal CHD) in two population...