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Neuropathic Pain and Sleep: A Review

This supplement has been sponsored by Pfizer, Italy. The article processing charges for this publication were also funded by Pfizer, Italy. Luigi Ferini-Strambi thanks Dr Ce´cile Duchesnes, PhD, of ... published. Disclosures. Luigi Ferini-Strambi has received honorarium from Pfizer, and payment for lectures and/or participation in advisory board from Resmed, Philips Respironics, UCB-Pharma, Valeas

Development and validation of the Maugeri Sleep Quality and Distress Inventory (MaSQuDI-17)

Braghiroli, Gian Luigi Balestroni, Raffaele Manni, Luigi Ferini Strambi, Vincenza Castronovo, Marco Zucconi, Eleonora Pinna, Ines Giorgi, Michele Terzaghi, Sara Marelli. Methodology: Elisa Morrone, Cinzia

Behavioural and Cognitive-Behavioural Treatments of Parasomnias

Parasomnias are unpleasant or undesirable behaviours or experiences that occur predominantly during or within close proximity to sleep. Pharmacological treatments of parasomnias are available, but their efficacy is established only for few disorders. Furthermore, most of these disorders tend spontaneously to remit with development. Nonpharmacological treatments therefore...

Functional Characterization of a CRH Missense Mutation Identified in an ADNFLE Family

Nocturnal frontal lobe epilepsy has been historically considered a channelopathy caused by mutations in subunits of the neuronal nicotinic acetylcholine receptor or in a recently reported potassium channel. However, these mutations account for only a minority of patients, and the existence of at least a new locus for the disease has been demonstrated. In 2005, we detected two...

Sleep in Genetically Confirmed Pantothenate Kinase-Associated Neurodegeneration: A Video-Polysomnographic Study

Pantothenate kinase-associated neurodegeneration (PKAN) is a familial or sporadic disease characterized by extrapyramidal and corticospinal signs with dementia. Patients show iron accumulation in the basal ganglia, with neuronal loss and gliosis. A mutation of pantothenate kinase (PANK2) gene localized on chromosome 20p13 has been described in familiar forms, as well as in...

Expression of mutant β2 nicotinic receptors during development is crucial for epileptogenesis

Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) is a focal form of epilepsy characterized by seizures occurring during non-REM sleep. We have developed and characterized the first mouse model for ADNFLE type III carrying the V287L mutation of the β2 subunit of neuronal nicotinic receptor. Mice expressing mutant receptors show a spontaneous epileptic phenotype by...

Progressive development of augmentation during long-term treatment with levodopa in restless legs syndrome: results of a prospective multi-center study

The European Restless Legs Syndrome (RLS) Study Group performed the first multi-center, long-term study systematically evaluating RLS augmentation under levodopa treatment. This prospective, open-label 6-month study was conducted in six European countries and included 65 patients (85% treatment naive) with idiopathic RLS. Levodopa was flexibly up-titrated to a maximum dose of 600...