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Search: authors:"M. Clynes"

4 papers found.
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Non-invasive Assessment of Lower Limb Geometry and Strength Using Hip Structural Analysis and Peripheral Quantitative Computed Tomography: A Population-Based Comparison

work may now consider whether each technique offers an independent contribution to hip fracture prediction. Compliance with Ethical Standards Conflict of interest The authors (A. E. Litwic, M. Clynes, H

Epidermal growth factor receptor as a potential therapeutic target in triple-negative breast cancer

Background: No proven targeted therapy is currently available for the treatment of triple-negative breast cancer (TNBC). Epidermal growth factor receptor (EGFR) is frequently overexpressed in TNBC. We studied the activity of EGFR antagonists alone, and in combination with chemotherapy, in TNBC cell lines. Materials and methods: EGFR and phosphorylated EGFR were measured by enzyme...

Inhibition of IGF1R activity enhances response to trastuzumab in HER-2-positive breast cancer cells

Background: Although trastuzumab has improved the prognosis for HER-2-positive breast cancer patients, not all HER-2-positive breast tumours respond to trastuzumab treatment and those that initially respond frequently develop resistance. Insulin-like growth factor-1 receptor (IGF1R) signalling has been previously implicated in trastuzumab resistance. We tested IGF1R inhibition to...