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16 papers found.
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The role of properdin in complement-mediated renal diseases: a new player in complement-inhibiting therapy?

Properdin is known as the only positive regulator of the complement system. Properdin promotes the activity of this defense system by stabilizing its key enzymatic complexes: the complement alternative pathway (AP) convertases. Besides, some studies have indicated a role for properdin as an initiator of complement activity. Though the AP is a powerful activation route of the...

Life-long tailoring of management for patients with hypertrophic cardiomyopathy

Cardiovascular Research Initiative: An initiative supported by the Netherlands Heart Foundation, CVON2014-40 DOSIS. Conflict of interest M. Michels, I. Olivotto, F.W. Asselbergs and J. van der Velden declare that

ATG24 Represses Autophagy and Differentiation and Is Essential for Homeostasy of the Flagellar Pocket in Trypanosoma brucei

. J Biol Chem 277 : 42875 - 80 . PMID: 12221086 19. Reggiori F , Klionsky D. ( 2005 ) Autophagosomes: biogenesis from scratch? Curr Opin Cell Biol 17 : 415 - 22 . PMID: 15978794 20. Gualdrón-López M ... , Michels PAM , Quiñones W , Cáceres AJ , Avilán L , Concepción JL. ( 2013 ) The function of glycosomes in the metabolism of trypanosomatid parasites and the promise of glycosomal proteins as drug targets

The evolution of organellar metabolism in unicellular eukaryotes

Metabolic innovation has facilitated the radiation of microbes into almost every niche environment on the Earth, and over geological time scales transformed the planet on which we live. A notable example of innovation is the evolution of oxygenic photosynthesis which was a prelude to the gradual transformation of an anoxic Earth into a world with oxygenated oceans and an oxygen...

Rewiring and regulation of cross-compartmentalized metabolism in protists

Michael L. Ginger 2 Geoffrey I. McFadden 1 Paul A. M. Michels 0 0 Research Unit for Tropical Diseases, de Duve Institute, and Laboratory of Biochemistry, Universite Catholique de Louvain , TROP

Channel-Forming Activities in the Glycosomal Fraction from the Bloodstream Form of Trypanosoma brucei

Background Glycosomes are a specialized form of peroxisomes (microbodies) present in unicellular eukaryotes that belong to the Kinetoplastea order, such as Trypanosoma and Leishmania species, parasitic protists causing severe diseases of livestock and humans in subtropical and tropical countries. The organelles harbour most enzymes of the glycolytic pathway that is responsible...

Enolase: A Key Player in the Metabolism and a Probable Virulence Factor of Trypanosomatid Parasites—Perspectives for Its Use as a Therapeutic Target

Quiñones,3 Limari González-González,3 Véronique Hannaert,2 Paul A. M. Michels,2 and Juan-Luis Concepción3 1Laboratorio de Fisiología, Facultad de Ciencias, Universidad de los Andes, 5101 Mérida, Venezuela ... . Gualdrón-López, V. Hannaert, and P. A. M. Michels gratefully acknowledge the Fonds de la Recherche Scientifique (F.R.S-FNRS) and associated foundations (FRSM and FRIA) and the Belgian Interuniversity

Naphthoquinone Derivatives Exert Their Antitrypanosomal Activity via a Multi-Target Mechanism

Capranico Reto Brun Barbara M. Bakker Paul A. M. Michels Leonardo Scapozza Maria Laura Bolognesi Andrea Cavalli Jayne Raper, New York University School of Medicine, United States of America Background and

The MDRD formula does not reflect GFR in ESRD patients

Background. The Modification of Diet in Renal Disease (MDRD) equation is widely used for the estimation of glomerular filtration rate (GFR) from plasma creatinine. It has been well validated in patients with various degrees of impaired kidney function, but not in patients with end-stage renal disease (ESRD). Plasma creatinine is determined by GFR and muscle mass. Importance of...

Patterns in blood pressure medication use in US incident dialysis patients over the first 6 months

McDermott Karen Bandeen-Roche Klemens B Meyer Deidra C Crews Julia J Scialla Dana C Miskulin Navdeep Tangri Bernard G Jaar Wieneke M Michels Albert W Wu L Ebony Boulware for the DEcIDE Network Patient

Genetic and Chemical Evaluation of Trypanosoma brucei Oleate Desaturase as a Candidate Drug Target

Background Trypanosomes can synthesize polyunsaturated fatty acids. Previously, we have shown that they possess stearoyl-CoA desaturase (SCD) and oleate desaturase (OD) to convert stearate (C18) into oleate (C18:1) and linoleate (C18:2), respectively. Here we examine if OD is essential to these parasites. Methodology Cultured procyclic (insect-stage) form (PCF) and bloodstream...

TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei

. Ferguson 8 Michael L. Ginger 5 Christiane Hertz-Fowler 6 Eduard J. Kerkhoven 3 Pascal M aser 4 Paul A. M. Michels 1 Archana Nayak 23 David W. Nes 2 Derek P. Nolan 0 Christian Olsen 10 Fatima Silva-Franco 6

Color vision in tree squirrels

Six tree squirrels were tested on a series of color discrimination problems utilizing various combinations of nine color filters ranging from 680 to 420 mu with intensity randomized. All animals reached criterion for all combinations by the 10th day of testing. These data support studies using indirect methods in demonstrating that tree squirrels possess color discrimination...